Department Events

Events

  • Dec
    2

    Kresimir Josic: Mathematical Modeling for the Rational Design of Synthetic Microbial Consortia

    McCormick-Engineering Sciences and Applied Mathematics

    4:00 PM M416, Technological Institute

    EVENT DETAILS

    Title: Mathematical Modeling for the Rational Design of Synthetic Microbial Consortia

    Speaker: Kresimir Josic Ph.D., The University of Houston

    Abstract: Synthetic microbial consortia have a number of advantages over isogenic system as biochemical and regulatory tasks can be divided between the strains. However, the complexity of these systems makes it difficult to engineer them from scratch. Coordinating gene expression is particularly challenging in spatially extended consortia because the range of signaling molecules is limited by diffusion.

    I will discuss two examples where mathematical modeling and analysis allowed us to understand experimentally observed dynamics in such a system, and use such modeling to control their behavior. First, I will show how modeling predicts that spatio-temporal coordination of gene expression can be achieved even when the spatial extent of a consortium is much greater than the diffusion distance of the signaling molecules. Experiments confirmed these observations and the need for an intrinsic positive feedback loop that amplifies and propagates intercellular signals. In a second example, we built a three-strain consortium that pulses in response to an external signal. We also developed a computational model that predicts the system's behavior at different strain ratios and can be used to control its dynamics. Our work thus shows that mathematical modeling can be used to rationally and predictably tune complex synthetic biological systems allowing us to engineer biology more rapidly.

    Co-Sponsored by the NSF-funded Research Training Grant in Quantitative Biological Modeling

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    TIME Monday, December 2, 2019 at 4:00 PM - 5:00 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Kendall Minta    kendall.minta@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics

  • Dec
    9

    Fall examinations begin

    University Academic Calendar

    All Day

    EVENT DETAILS

    TIME Monday, December 9, 2019

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Dec
    14

    Winter Break Begins

    University Academic Calendar

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    EVENT DETAILS

    TIME Saturday, December 14, 2019

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Dec
    14

    Northwestern Engineering PhD Hooding and Master's Recognition Ceremony

    McCormick School of Engineering and Applied Science

    4:00 PM Pick-Staiger Concert Hall

    EVENT DETAILS

    TIME Saturday, December 14, 2019 at 4:00 PM - 5:30 PM

    LOCATION Pick-Staiger Concert Hall    map it

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    CONTACT Paula Straaton    p-straaton@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Dec
    26

    Winter Recess - University Closed

    University Academic Calendar

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    EVENT DETAILS

    TIME Thursday, December 26, 2019

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

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  • Dec
    27

    Winter Recess - University Closed

    University Academic Calendar

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    EVENT DETAILS

    TIME Friday, December 27, 2019

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

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  • Dec
    30

    Winter Recess University Closed

    University Academic Calendar

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    EVENT DETAILS

    TIME Monday, December 30, 2019

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

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