Faculty Directory

Lisa Volpatti

Assistant Professor of Biomedical Engineering

Assistant Professor of Chemical and Biological Engineering

Contact

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Volpatti Research Group

Departments

Biomedical Engineering

Chemical and Biological Engineering

Research Interests

Our research aims to improve the safety and efficacy of immunotherapies by reshaping how immune signals are delivered and experienced by cells. We engineer proteins and nanomaterials that precisely control the location, timing, and strength of immune modulation. Ultimately, we aim to establish broadly applicable design principles for next-generation immunotherapies that are both powerful and well tolerated.

Selected Publications

• Kang, Seounghun; Mansurov, Aslan; Kurtanich, Trevin; Chun, Hye Rin; Slezak, Anna J.; Volpatti, Lisa R.; Chang, Kevin; Wang, Thomas; Alpar, Aaron T.; Refvik, Kirsten C.; Hansen, O. Isabella; Borjas, Gustavo J.; Berg, Brendan T.K.; Shim, Ha Na; Hultgren, Kevin T.; Gomes, Suzana; Wang, Yue; Solanki, Ani; Ishihara, Jun; Swartz, Melody A.; Hubbell, Jeffrey A., Engineered GM-CSF polarizes protumorigenic tumor-associated macrophages to an antitumorigenic phenotype and potently synergizes with IL-12 immunotherapy, Journal for immunotherapy of cancer (2024).
• Kang, Seounghun; Mansurov, Aslan; Kurtanich, Trevin; Chun, Hye Rin; Slezak, Anna J.; Volpatti, Lisa R.; Chang, Kevin; Wang, Thomas; Alpar, Aaron T.; Refvik, Kirsten C.; Hansen, O. Isabella; Borjas, Gustavo J.; Shim, Ha Na; Hultgren, Kevin T.; Gomes, Suzana; Solanki, Ani; Ishihara, Jun; Swartz, Melody A.; Hubbell, Jeffrey A., Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity, Science Advances (2023).