Faculty Directory
Shana Kelley

Neena B. Schwartz Professor of Chemistry and Biomedical Engineering


2145 Sheridan Road
Evanston, IL 60208-3109

Email Shana Kelley


Kelley Labratory


Biomedical Engineering


Ph.D. California Institute of Technology

NIH Postdoctoral Fellow, Scripps Research Institute

Research Interests

Diagnostic and Therapeutic Development, Sensors, Cell Therapy, Functional Genomics

The Kelley Group uses a highly multidisciplinary approach to develop new tools for the diagnosis of disease and the development of new disease therapies.  A variety of projects are underway that focus on the development of biomolecular sensors, phenotypic screening platforms and molecular delivery vectors.  We use cutting-edge techniques including CRISPR screening and cellular engineering to develop innovative new solutions for biomedicine. Our research group includes students, postdoctoral fellows and research professors with scientific backgrounds spanning chemistry, biology, engineering and many other fields.  Over the ten years, we have generated ~200 publications, ~50 Ph.D. students/postdoctoral trainees, and have started three new companies based on technologies developed in the group.  Our trainees have taken exciting positions at top-tier universities and companies around the world.

Significant Recognition

  • Fellow, Royal Society of Canada, 2021
  • Order of Ontario, 2021
  • AFPC Pfizer Award, 2020
  • Distinguished Visiting Fellow, Rowland Institute, Harvard University, 2018
  • ACS Nanoscience Award, 2017
  • Somorjai Visiting Miller Professorship (UC Berkeley), 2017
  • SLAS Innovation Award, 2016
  • NSERC Brockhouse Award, 2016
  • Fellow, American Institute for Medical and Biological Engineering, 2016
  • Fellow, Canadian Academy of Health Sciences, 2016
  • University of Toronto Distinguished Professor Award, 2013
  • Steacie Prize, 2011
  • University of Toronto Inventor of the Year, 2011
  • NSERC E.W.R Steacie Fellowship, 2010
  • Named one of "Canada's Top 40 under 40" by Globe & Mail/Caldwell Part, 2008
  • Pittsburgh Conference Achievement Award, 2006
  • Camille Drefus Teacher-Scholar Award, 2005
  • TR100: Voted one of the top 100 innovators by Technology Review Magazine, 2004
  • Alfred P. Sloan Fellowship, 2004
  • NSF CAREER Award, 2004
  • Dreyfus New Faculty Award, 2000
  • Research Innovation Award, 2000

Selected Publications

“Reagentless Biomolecular Analysis Using a Nanoscale Molecular Pendulum.”
J. Das, S. Gomis, J.B. Chen, H. Yousefi, S. Ahmed, A. Mahmud, W. Zhou, E. H. Sargent, S.O. Kelley
Nature Chemistry, 2021, 14, 428-434. 

“Detection of SARS-CoV-2 Viral Particles using Direct, Reagent-Free Electrochemical Sensing.” 
H. Yousefi, A. Mahmud, D. Chang, J. Das, S. Gomis, J.B. Chen, H. Wang, T. Been, L.Yip, E. Coomes, Z. Li, S. Mubareka, A. McGeer, N. Christie, S. Gray-Owen, A. Cochrane, J.M. Rini, E.H. Sargent, S.O. Kelley
Journal of the American Chemical Society, 2021, 143, 1722-1727.

“Tracking the Expression of Therapeutic Protein Targets in Rare Cells by Antibody-Mediated Nanoparticle Labelling and Magnetic Sorting.”
M. Labib, Z. Wang, S.U. Ahmed, R.M. Mohamadi, B. Duong, B. Green, E.H. Sargent
Nature Biomedical Engineering, 2021, 5, 41-52.

“High-Throughput Genome-Wide Phenotypic Screening via Immunomagnetic Cell Sorting.”
B. Mair, P.M. Aldridge, R.S. Atwal, D. Philpott, M. Zhang, S.N. Masud, M. Labib, A.H.Y. Tong, E.H. Sargent, S. Angers, J. Moffat, S.O. Kelley
Nature Biomedical Engineering, 2019, 3, 796-805.

"Single Cell mRNA Cytometry via Sequence-Specific Nanoparticle Clustering and Trapping."
M. Labib, R.M. Mohamadi, M. Poudineh, S.U. Ahmed, I. Ivanov, C.L. Huang, M. Moosavi, E.H. Sargent, S.O. Kelley.
Nature Chemistry, 2018, 10, 489-495. 

“Tracking the Dynamics of Circulating Tumor Cell Phenotypes Using Nanoparticle-Mediated Magnetic Ranking.” 
M. Poudineh, P.M. Aldridge, S. Ahmed, B.J. Green, L. Kermanshah, V. Nguyen, C. Tu, R.M. Mohamadi, R.K. Nam, A. Hansen, S.S. Sridhar, A. Finelli, N.E. Fleshner, A.M. Joshua,  E.H. Sargent,  S.O. Kelley 
Nature Nanotechnology, 2017, 12, 274-282. 

"Mitochondrial DNA Repair and Replication Proteins Revealed by Targeted Chemical Probes." 
S. Wisnovsky, S.R. Jean, S.O. Kelley
Nature Chemical Biology, 2016, 12, 567-573. 

“An Electrochemical Clamp Assay for Direct, Rapid Analysis of Circulating Nucleic Acids in Serum.” 
 J. Das, I. Ivanov, E.H. Sargent, S.O. Kelley 
 Nature Chemistry, 2015, 7, 569-575.