Faculty Directory

Colin Hisey

Assistant Professor of Biomedical Engineering

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Departments

Biomedical Engineering

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Research Interests

Our lab explores biomedical micro- and nanotechnology, with a strong focus on extracellular vesicles (EVs). EVs are micro- and nanoscale lipid-enclosed particles that contain diverse molecular cargo and circulate in all bodily fluids as a form of intercellular communication. However, despite their potential in applications ranging from diagnostics to therapeutics, their clinical translation is limited by several significant technical challenges. By combining engineering principles and a strong foundation in micro-nanofabrication with EV production, isolation, and characterization techniques, we aim to develop novel platform technologies that accelerate EV applications ranging from cancer and infectious diseases to neuroscience and reproductive health.

Selected Publications

• DePalma, Thomas J.; Hisey, Colin L.; Hughes, Kennedy; Fraas, David; Tawfik, Marie; Scharenberg, Jason; Wiggins, Sydney; Nguyen, Kim Truc; Hansford, Derek J.; Reátegui, Eduardo; Skardal, Aleksander, Tuning a bioengineered hydrogel for studying astrocyte reactivity in glioblastoma, Acta Biomaterialia (2024).
• Kazemzadeh, Mohammadrahim; Martinez-Calderon, Miguel; Otupiri, Robert; Artuyants, Anastasiia; Lowe, Moimoi; Ning, Xia; Reategui, Eduardo; Schultz, Zachary D.; Xu, Weiliang; Blenkiron, Cherie; Chamley, Lawrence W.; Broderick, Neil G.R.; Hisey, Colin L., Deep autoencoder as an interpretable tool for Raman spectroscopy investigation of chemical and extracellular vesicle mixtures, Biomedical Optics Express (2024).
• , ; Welsh, Joshua A.; Goberdhan, Deborah C.I.; O’Driscoll, Lorraine; Buzas, Edit I.; Blenkiron, Cherie; Bussolati, Benedetta; Cai, Houjian; Di Vizio, Dolores; Driedonks, Tom A.P.; Erdbrügger, Uta; Falcon-Perez, Juan M.; Fu, Qing Ling; Hill, Andrew F.; Lenassi, Metka; Lim, Sai Kiang; Mahoney, M. ỹ.G.; Mohanty, Sujata; Möller, Andreas; Nieuwland, Rienk; Ochiya, Takahiro; Sahoo, Susmita; Torrecilhas, Ana C.; Zheng, Lei; Zijlstra, Andries; Abuelreich, Sarah; Bagabas, Reem; Bergese, Paolo; Bridges, Esther M.; Brucale, Marco; Burger, Dylan; Carney, Randy P.; Cocucci, Emanuele; Crescitelli, Rossella; Hanser, Edveena; Harris, Adrian L.; Haughey, Norman J.; Hendrix, An; Ivanov, Alexander R.; Jovanovic-Talisman, Tijana; Kruh-Garcia, Nicole A.; Faustino, Vroniqa Ku’ulei Lyn; Kyburz, Diego; Lässer, Cecilia; Lennon, Kathleen M.; Lötvall, Jan; Maddox, Adam L.; Martens-Uzunova, Elena S.; Mizenko, Rachel R.; Newman, Lauren A.; Hisey, Colin L., Minimal information for studies of extracellular vesicles (MISEV2023), Journal of Extracellular Vesicles (2024).
• Zhang, Jingjing; Rima, Xilal Y.; Wang, Xinyu; Nguyen, Luong T.H.; Huntoon, Kristin; Ma, Yifan; Palacio, Paola Loreto; Nguyen, Kim Truc; Albert, Karunya; Duong-Thi, Minh Dao; Walters, Nicole; Kwak, Kwang Joo; Yoon, Min Jin; Li, Hong; Doon-Ralls, Jacob; Hisey, Colin L.; Lee, Daeyong; Wang, Yifan; Ha, Jonghoon; Scherler, Kelsey; Fallen, Shannon; Lee, Inyoul; Palmer, Andre F.; Jiang, Wen; Magaña, Setty M.; Wang, Kai; Kim, Betty Y.S.; Lee, L. James; Reátegui, Eduardo, Engineering a tunable micropattern-array assay to sort single extracellular vesicles and particles to detect RNA and protein in situ, Journal of Extracellular Vesicles (2023).