Walter Dill Scott Professor of Biomedical Engineering

Contact

2170 Campus Drive
Silverman Hall 3627
Evanston, IL 60208-2850

Email Vadim Backman

Website

Backman Laboratory

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Departments

Biomedical Engineering

Affiliations

PhD Program in Applied Physics

PhD Program in Interdisciplinary Biological Sciences

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Education

Ph.D. Medical Engineering and Medical Physics, Harvard University - MIT, Cambridge, MA

M.S. Physics, MIT, Cambridge, MA

M.S. Physics, St. Petersburg Polytechnic Institute, St. Petersburg, Russia

B.S. Physics (Hons), St. Petersburg Polytechnic Institute, St. Petersburg, Russia

Research Interests

Biophotonics; nanoscale imaging; physical biology of gene expression regulation; optical and molecular technologies for cancer diagnosis and therapeutics; biophysics of cellular nanostructure and nanoenvironment; cancer biomarkers

Selected Publications

RECENT JOURNAL PUBLICATIONS

L.M. Almassalha, A. Tiwari, P.T. Ruhoff, Y. Stypula-Cyrus, H. Matsuda, M.A. Dela Cruz, J.E. Chandler, C. White, C. Maneval, H. Subramanian, I. Szleifer, H. Roy, and V. Backman, “The global relationship between chromatin physical topology, fractal structure, and gene expression”, Scientific Reports, 7:41061, DOI: 10.1038/srep41061 (2017).

R.K. Wali, N. Momi, M. Dela Cruz, A.H. Calderwood, Y. Stypula-Cyrus, L. Almassalha, A. Chhaparia, C.R. Weber, A. Radosevich, A.K. Tiwari, B. Latif, V. Backman and H.K. Roy, “Higher-order chromatin modulator cohesion SA1 is an early biomarker for colon carcinogenesis: race-specific implications”, Cancer Prevention Research, DOI: 10.1158/1940-6207.CAPR-16-0054 (2016). PMC5093027

J. Yi, Z. Puyang, L. Feng, L. Duan, P. Liang, V. Backman, X. Liu, and H. Zhang, “Optical detection of early damages in retinal ganglion cells in a mouse model of partial optic nerve crush injury”, IOVS, 57(13) 5665-5671 (2016). PMC5089219

G. Spicer, S. Azarin, J. Yi, S. Young, R. Ellis, G. Bauer, L. Shea, and V. Backman, “Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography”, Phys Med Biol. 61(19) 6892-6904 (2016). PMC5056859

W. Wu, A.J. Radosevich, A. Eshein, T.Q. Nguyen, J. Yi, L. Cherkezyan, H.K. Roy, I. Szleifer, V. Backman, “Using electron microscopy to calculate optical properties of biological samples”, Biomedical Optics Express 7(11), 4749-4762 (2016). PMC5119613

L.M. Almassalha, G.M. Bauer, J. Chandler, S. Gladstein, L. Cherkezyan, Y. Stypula-Cyrus, S. Weinberg, D. Zhang, P. Thusgaard Ruhoff, H. Roy, H. Subramanian, N. Chandel, I. Szleifer, V. Backman, “Label-free imaging of the native, living cellular nano-architecture using partial-wave spectroscopic microscopy”, PNAS, 113(42) E6372-E6381 (2016). PMC5081614.

T. Swain, J. Vega-Perkins, W. Oestreich, C. Triebold, E. DuBois, J. Henss, A. Baird, M. Siple, V. Backman, and L. Marcelino, “Coral bleaching response index: a new tool to standardize and compare susceptibility to thermal bleaching”, Global Change Biology, 22(7) 2475-88 (2016). MSID: 849498

H. Subramanian, P. Viswanathan, L. Cherkezyan, R. Iyengar, S. Rozhok, M. Verleye, J. Derbas, J. Czarnecki, H.K. Roy, V. Backman, “Procedures for risk-stratification of lung cancer using buccal nanocytology”, Biomedical Optics Express, 7(9) 3795-3810 (2016). PMC5030050.

B.E. Urban, B. Dong, V. Backman, C. Sun, H.F. Zhang, “Subsurface super-resolution imaging of unstained polymer nanostructures”, Scientific Reports, 6, 28156; doi: 10.1038/srep28156 (2016). PMC4926209.

D. Zhang, I. Capoglu, Y. Li, L. Cherkezyan, J. Chandler, G. Spicer, H. Subramanian, A. Taflove, and V. Backman, “FDTD-based optical microscopy simulation of dispersive media facilitates the development of optical imaging techniques”, JBO, 21(6): 65004 doi:10.1117/1.JBO.21.6.065004 (2016). PMC4901185.

B. Dong, L. Almassalha, Y. Stypula-Cyrus, B.E. Urban, T.Q. Nguyen, C. Sun, H.F. Zhang, and V. Backman, “Super-resolution intrinsic fluorescence imaging of chromatin using native, unmodified nucleic acids for contrast”, PNAS, 113(35), 9716-9721 (2016). PMC5024634.

J.E. Chandler, Y. Stypula-Cyrus, L. Almassalha, G. Bauer, L. Bowen, H. Subramanian, I. Szleifer, and V. Backman, “Colocalization of cellular nanostructure using confocal fluorescence and partial wave spectroscopy”, Journal of Biophotonics, 1-8, doi: 10.1002/jbio.201500298 (2016). PMC5112146

P. Pradhan, D.J. Park, I. Capoglu, H. Subramanian, D. Damania, L. Cherkezyan, A. Taflove, V. Backman, “Enhancing the sensitivity of mesoscopic light reflection statistics in weakly disordered media by interface reflections”, International Journal of Modern Physics B, 30(23), 1650155 (2016). MSID: 849492

L.M. Almassalha, G.M. Bauer, J. Chandler, S. Gladstein, I. Szleifer, H.K. Roy, and V. Backman, “The greater genomic landscape: the heterogeneous evolution of cancer”, Cancer Research, doi: 10.1158/0008-5472.CAN-16-0585 (2016). PMC5084919.

B. Dong, L. Almassalha, B.E. Urban, T.Q. Nguyen, S. Khuon, T.L. Chew, V. Backman, C. Sun, H.F. Zhang, “Super-resolution spectroscopic microscopy via photon localization”, Nature Communications, 7:12290 doi: 10.1038/ncomms12290 (2016). PMC4962472.

J. Chandler, L. Cherkezyan, H. Subramanian, V. Backman,“Nanoscale refractive index fluctua tions detected via sparse spectral microscopy”, Biomedical Optics Express, 7(3), 883-893 (2016).

T.D. Swain, E. DuBois, A. Gomes, V.P. Stoyneva, A.J. Radosevich, J. Henss, M.E. Wagner, E. Velazquez, J. Traub, B.J. Kennedy, C.M. Janczak, A.A. Grigorescu, M.W. Westneat, K. Sanborn, S. Levine, M. Schick, G. Parsons, J.D. Rogers, V. Backman, L.A. Marcelino, “Skeletal light scattering decreases bleaching susceptibility of reef-building corals”, BMC Ecol., 16(1) (2016). PMC4800776

Q. Miao, J. Derbas, A. Eid, H. Subramanian, V. Backman, “Automated cell selection using support vector machine for application to spectral nanocytology”, BioMed Research International, 2016(3), 1-10 (2016). PMC4745312

D. Zhang, L. Cherkezyan, I. Capoglu, H. Subramanian, J. Chandler, S. Thompson, A. Taflove, V. Backman, “Spectroscopic microscopy can quantify the statistics of subdiffractional refractive index fluctuations in media with random rough surfaces”, Optics Letters, 40(21), 4931-4934 (2015).

J. Yi, Y. Stypula-Cyrus, C.S. Blaha, H.K. Roy, V. Backman, “Fractal characterization of chromatin decompaction in live cells”, Biophysical Journal, 109(11), 2218-2226 (2015). PMC4675813

L. Cherkezyan, D. Zhang, H. Subramanian, A. Taflove, V. Backman, “Reconstruction of explicit structural properties at the nanoscale via spectroscopic microscopy”, JBO, 21(2), 025007 (2016). PMC4756051

N. Momi, V. Backman, C. Brendler, H.K. Roy, “Harnessing novel modalities: field carcinogenesis detection for personalizing prostate cancer management”, Future Oncology, 11, 2737-41 (2015)

B.E. Urban, B. Dong, Z. Zhang, V. Backman, C. Sun, H.F. Zhang, “Super-resolution two-photon microscopy via scanning patterned illumination”, Physical Review E, 91(4):042703 (2015). PMC4565794

A.J. Radosevich, N.N. Mutyal, A. Eshein, T.Q. Nguyen, B. Gould, J. Rogers, M. Goldberg, L. Bianchi, V. Konda, D. Rex, E. Yen, J. Van Dam, H.K. Roy, V. Backman, “Rectal optical markers for in vivo risk stratification of premalignant colorectal lesions”, Clinical Cancer Research, 21(19), 4337-55 (2015). PMC4592390

J. Yi, W. Liu, S. Chen, N. Sheibani, C.M. Sorenson, A.A. Fawzi, V. Backman, R.A. Linsenmeier, H.F. Zhang, “Visible-light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation”, Light: Science and Application, 4, e334 (2015). PMC4674267

A.J. Radosevich, A. Eshein, T.Q. Nguyen, V. Backman, “Subdiffusion reflectance spectroscopy to measure tissue ultrastructure and microvasculature: model and inverse algorithm”, JBO, 20(9):97002 (2015).

S.M. Azarin, J. Yi, R.M. Gower, B.A. Aguado, M.E. Sullivan, A.G. Goodman, E.J. Jiang, S.S. Rao, Y. Ren, V. Backman, J.S. Jeruss, L. Shea, “In vivo capture and label-free detection of early metastatic cells”, Nature Communications,  6:8094 (2015). PMC4563812

S. Chen, J. Yi, W. Liu, V. Backman, H. Zhang, “Monte Carlo investigation of optical coherence tomography retinal oximetry”, IEEE TBME, 62(9), 2308-2315 (2015). PMC4783381

B.D. Jovanovic, H. Subramanian, I.B. Helenowski, H.K. Roy, V. Backman, “Clinical trial laboratory data nested with in subject: components of variance, sample size and cost”, Biometrics & Biostatistics International Journal, 2(2):00029 (2015).

N.N. Mutyal, A.J. Radosevich, S. Bajaj, V. Konda, U.D. Siddiqui, I. Waxman, M.J. Goldberg, J.D. Rogers, B. Gould, A. Eshein, S. Upadhye, A. Koons, M. Gonzalez, H.K. Roy, V. Backman, “In-vivo risk analysis of pancreatic cancer through optical characterization of duodenal mucosa”, Pancreas, 44(5), 735-741 (2015). PMC4464933.

H.K. Roy, C. Brendler, H. Subramanian, D. Zhang, C. Maneval, J. Chandler, K. Kaul, B. Helfand, C. Wang, M. Quinn, J. Petkewicz, M. Paterakos, V. Backman, “Nanocytological Field Carcinogenesis Detection to Mitigate Overdiagnosis of Prostate Cancer: A Proof of Concept Study”, PLoS One, 10(2): e0115999 (2015).

M. Dela Cruz, R.K. Wali, L.K. Bianchi, A.J. Radosevich, S.E. Crawford, L. Jepeal, M.J. Goldberg, J. Weinstein, N. Momi, P. Roy, A.H. Calderwood, V. Backman, H.K. Roy, “Colonic Mucosal Fatty Acid Synthase as an Early Biomarker for Colorectal Neoplasia: Modulation by Obesity and Gender”, Cancer Epidemiology, Biomarkers & Prevention, 23(11), 2413-2421 (2014).

A. Doronin, A.J. Radosevich, V. Backman, I. Meglinski, “Two electric field Monte Carlo models of coherent back scattering of polarized light”, Journal of the Optical Society of America, 31(11), 2394-2400 (2014).

M. Patel, A. Gomes, S. Ruderman, D. Hardee, S. Crespo, M. Raimondo, T. Woodward, V. Backman, H.K. Roy, M. Wallace, “Polarization gating spectroscopy of normal-appearing duodenal mucosa to detect pancreas cancer”, Gastrointestinal Endoscopy, 80(5), 786-793 (2014). PMC4241379

J.D. Rogers, A.J. Radosevich, J. Yi, V. Backman, “Modeling light scattering in tissue as continuous random media using a versatile refractive index correlation function”, IEEE JSTQE, 20(02) 7000514 (2014). NIHMSID: 603537

H. Matsuda, G.G. Putzel, V. Backman, I. Szleifer,“Macromo lecular crowding as a regulator of gene transcription”, Biophysical Journal, 106, 1801-1810 (2014.) PMC4008821

J. Yi, A.J. Radosevich, Y. Stypula, N. Mutyal, S.M. Azarin, E.L. Horcher, M. Goldberg, L. Bianchi, S. Bajaj, H.K. Roy, V. Backman, “Spatially-resolved optical and ultra-structural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography”, JBO, 19(3), 036013 (2014). PMC4019430

Y. Stypula-Cyrus, N.N. Mutyal, M.A. Dela Cruz, D.P. Kunte, A.J. Radosevich, R.K.Wali, H.K. Roy, V. Backman, “End-binding protein 1 (EB1) up-regulation is an early event in colorectal carcinogenesis”, FEBS Letters, 5(3), 829-835 (2014). PMC4103177

L. Cherkezyan, H. Subramanian, V. Backman, “What structural length-scales can be detected by the spectral variance of a microscope image?”, Optics Letters,  39(15), 4290-4293 (2014).

J. Yi, S. Chen, V. Backman, H.F. Zhang, “In vivo functional microangiography by visible-light optical coherence tomography”, Biomedical Optics Express, 5(10), 3603-3612 (2014). PMC4206328

R. K. Wali, T. A. Hensing, D. W. Ray, M. Dela Cruz, A. Tiwari, A. Radosevich, L. Jepeal, H.C. Fernando, V. Litle, M. Charlot, N. Momi, V. Backman, H.K. Roy, “Buccal microRNA dysregulation in lung field carcinogenesis: gender specific implications”, International Journal of Oncology, 45(3), 1209-1215 (2014). PMC4144027.

A.J. Radosevich, N.N. Mutyal, J.D. Rogers, B. Gould, T.A. Hensing, D. Ray, V. Backman, H.K.Roy, “Buccal spectral markers for lung cancer risk stratification”, PLoS One, 9(10): e110157 (2014). PMC4192585

L. Cherkezyan, Y. Stypula-Cyrus, H. Subramanian, C. White, M. Dela Cruz, R.K. Wali, M.J. Goldberg, L.K. Bianchi, H.K. Roy, V. Backman, “Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study”, Biomed Central Cancer, 14(189), (2014). PMC3995586

Y. Stypula-Cyrus, D. Damania, D.P. Kunte, M. De La Cruz, H. Subramanian, H.K. Roy, V. Backman, “HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure”, PLoS One, 8(5): e64600 (2013). PMC3665824

K. Phillips, D. Damania, H. Subramanian, V. Backman, E. Anderson, M.H. Wong, O. McCarty, “Network signatures of nuclear and cytoplasmic density alterations in a model of pre- and post-metastatic colorectal cancer”, J. Biomedical Optics, 19(1), 016016 (2013). PMC4019418

I.R. Capoglu, J.D. Rogers, A. Taflove, V. Backman, “The microscope in a computer: Image synthesis from three-dimensional full-vector solutions of Maxwell’s equations at the nanometer scale”, Progress in Optics, 57, 1-91 (2013).

D.P.Kunte, M. De LaCruz, R.K. Wali, Y. Stypula, A.K. Tiwari, J. Brasky, T. Gibson, P. Subramaniyan, A. Menon, V. Backman, H.K. Roy, “Dysregulation of MicroRNAs in Early Colon Carcinogenesis: Implications for Screening”, PLoS One, (9)7, e45591(2012). PMC3458063

V. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. Goldberg, J. Chennat, L. Karl, M. Ferguson, I. Waxman, H. Roy, V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening”, Endoscopy, 45, 983-988, (2013).PMC4195538

J. Chandler, H. Subramanian, C.D. Maneval, C.A. White, V. Backman, “High-speed spectral nanocytology for early cancer screening”, J. Biomedical Optics, 18(11), 117002 (2013). PMC3817856

Ji Yi, Andrew J. Radosevich, Jeremy D. Rogers, Sam C.P. Norris, İlker R. Çapoğlu, Allen Taflove, and Vadim Backman, "Can OCT be sensitive to nanoscale structural alterations in biological tissue?," Opt. Express 21, 9043-9059 (2013). PMC3641881

H.K. Roy, D.P. Damania, M. DelaCruz, D.P. Kunte, H. Subramanian, S.E.Crawford, A.K. Tiwari, R.K. Wali, V. Backman, “Nano-architectural alterations in mucus layer fecal colonocytes in field carcinogenesis: potential for screening”, Cancer Prevention Research, 6, 1111-1119 (2013). PMC387374

A.J. Radosevich, N.N. Mutyal, J. Yi, Y. Stypula-Cyrus, J.D. Rogers, M.J. Goldberg, L.K. Bianchi, S. Bajaj, H.K. Roy, V. Backman, “Ultrastructural alterations in field carcinogenesis measured by enhanced backscattering spectroscopy”, JBO, 18(9), 0970021-09700211 (2013). PMC3764252

L. Cherkezyan, I. Capoglu, H. Subramanian, J.D. Rogers, D. Damania, A. Taflove, V. Backman, “Interferometric spectroscopy of scattered light can quantify the statistics of subdifractional refractive-index fluctuations”, PRL, 111, 033903 (2013). PMC4123763

D. Damania, H.K. Roy, D. Kunte, J.A. Hurteau, H. Subramanian, L. Cherkezyan, M. Shah, N. Krosnjar, V. Backman, “Insights into the field carcinogenesis of ovarian cancer based on the nanocytology of endocervical and endometrial epithelial cancer cells” International Journal of Cancer, 133(5), 1143-1152 (2013). PMC3695064

L.A. Marcelino, M.W. Westneat, V. Stoyneva, J. Henss, J.D. Rogers, A. Radosevich, V. Turzhitsky, M. Siple, A. Fang, T.D. Swain, J. Fung, V. Backman, “Modulation of light-enhancement to symbiotic algae by light-scattering in corals and evolutionary trends in bleaching”, PLoS One, 8(4) e61492 (2013). PMC3632607

The Physical Sciences-Oncology Centers Network. "A physical sciences network characterization of non-tumorigenic and metastatic cells". Sci. Rep.3, 1449; DOI:10.1038/srep01449 (2013). PMC3636513

T. Tan, A. Taflove, V. Backman, “Single realization stochastic FDTD for weak scattering waves in biological random media”, IEEE Trans. Ant. Prop., 61(2), 818-828 (2013).

I. Capoglu, A. Taflove, V. Backman, “Computation of tightly-focused laser beams in the FDTD method”, Optics Express, 21(1), 87-101 (2013).

I. Avital, R.C. Langan, T.A. Summers, S.R. Steele, S.A. Waldman, V. Backman, J. Yee, A. Nissan, P. Young, C. Womeldorph, P. Mancuso, R. Mueller, K. Noto, W. Grundfest, A.J. Bilchik, Mladjan Protic, M. Daumer, J. Eberhardt, Y.G. Man, B. LDM Brucher, A. Stojadinovic “Evidence-based guidelines for precision risk stratification-based screening (PRSBS) for colorectal cancer: lessons learned from the US armed forces: consensus and future directions”, Journal of Cancer, 4(3), 172-192 (2013).

V. Backman, H.K. Roy, “Advances in biophotonics detection of field carcinogenesis for colon cancer risk stratification”, Journal of Cancer, 4(3), 251-261 (2013) (Special issue, invited paper).

A.J. Gomes, V. Backman, “Analytical light reflectance models for overlapping-illumination and collection area geometries”, Applied Optics, 51(33), 8013-8021 (2012).

H.K. Roy, V. Backman, “Spectroscopic applications in gastrointestinal endoscopy”, Clinical Gastroenterology and Hepatology,10(12), 1335-1341 (2012).

A.J. Radosevich, J. Yi, J.D. Rogers, V. Backman, “Structural length-scale sensitivities of diffuse reflectance in continuous random media under the Born approximation”, Optics Letters, 37(24), 5220-5222 (2012).

A. Radosevich, J.D. Rogers, I. Capoglu, N. Mutyal, P. Pradhan, V. Backman, “Open source software for electric field Monte Carlo simulation of coherent backscattering in biological media containing birefringence”, J. Biomedical Optics, 17(11), 115001-1 – 115001-13 (2012).

J. Yi, V. Backman, “Imaging a full set of optical scattering properties of biological tissue by inverse spectroscopic optical coherence tomography”, Optics Letters, 37(21), 4443-4445 (2012).

N. Mutyal, A. Radosevich, B. Gould, J.D. Rogers, A. Gomes, V. Turzhitsky, V. Backman, “A fiber optic probe design to measure depth-limited optical properties in vivo with Low-coherence Enhanced Backscattering (LEBS) Spectroscopy”, Optics Express, 20(18), 19643-19657 (2012).

S.D. Strasser, G. Shekhawat, J.D. Rogers, V.P. Dravid, A. Taflove, V. Backman, “Near-field penetrating optical microscopy: A live cell nanoscale refractive index measurement technique for quantification of internal macromolecular density”, Optics Letters, 37(4), 506-508 (2012) NIHMSID #376353.

D. Damania, H.K. Roy, H. Subramanian, M.J. Goldberg, D.S. Weinberg, J. Muldoon, L. Cherkezyan, Y. Zhu, L.K. Bianchi, D. Shah, P. Pradhan, M. Borkar, H. Lynch, V. Backman, “Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization”, Cancer Research, 72(11), 2720-2727 (2012).

L. Cherkezyan, H. Subramanian, V. Stoyneva, J. Rogers, S. Yang, D. Damania, A. Taflove, V. Backman, “Targeted alteration of real and imaginary refractive index of biological cells by histological staining”, Optics Letters, 37(10), 1601-1603 (2012) NIHMSID #377111

A. Radosevich, N. Mutyal, V. Turzhitsky, J. Rogers, J. Yi, A. Taflove, V. Backman, “Measurement of the spatial backscattering impulse-response at short length-scales with polarized enhanced backscattering (EBS)”, Optics Letters, 36(24), 4737-4739 (2011)

H. K. Roy, M. J. Goldberg, S. Bajaj, V. Backman, “Colonoscopic Optical Biopsy: Bridging Technological Advances to Clinical Practice”, Gastroenterology, 140(7), 1863–1880 (2011). (invited editorial, cover article)

J. S. Kim, V. Backman, I. Szleifer, “Crowding-induced structural alterations of random-loop chromosome model”, Physical Review Letters, 106, 168102, 1-4 (2011).

S. R. Gandhi, A. K. Tiwari, D. P. Kunte, M. A. De la Cruz, Y. Stypula, T. Gibson, J. Brasky, V. Backman, R. K. Wali, H. K. Roy, “Association of stem-like cells in gender-specific chemoprevention against intestinal neoplasia in MIN mouse”, Oncology Reports, 26(5), 1127-1132, (2011).

S. Yang, A. Taflove, V. Backman, “Experimental Confirmation at Visible Light Wavelengths of the Giant Backscattering Perturbation Phenomenon of the Photonic Nanojet”, Optics Express, 19(8), 7074-7093 (2011).

V. Backman, H. K. Roy, “Light-scattering Technologies for Field Carcinogenesis Detection: A Modality for Endoscopic Pre-screening”, Gastroenterology, 140(1), 35-41 (2011).

H. K. Roy, T. Hensing, V. Backman, “Nanocytology for field carcinogenesis detection: novel paradigm for lung cancer risk stratification”, Future Oncology, 7(11) (2011) (editorial).

J. S. Kim, P. Pradhan, V. Backman, I. Szleifer, “Influence of chromosome density variations on the increase in nuclear disorder strength in carcinogenesis”, Physical Oncology, 8(1), 015004, 1-6 (2011).

P. Pradhan, D. Damania, H. Joshi, V. Turzhitsky, H. Subramanian, H.K. Roy, A. Taflove, V. Dravid, V. Backman, “Quantification of Nanoscale Density Fluctuations by Electron Microscopy: probing cellular alterations in early carcinogenesis”, Phys. Biol. 8 (2011) 026012 (9pp).

N. N. Mutyal, A. Radosevich, A. Tiwari, Y. Stypula, R. Wali, , V. Turzhitsky, J. D. Rogers, H. K. Roy ,V. Backman, “Structural changes induced by field carcinogenesis in colorectal cells measured by Low-Coherence Enhanced Backscattering Spectroscopy”, submitted (2011).

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. Mutyal, P. Pradhan, I. R. Capoglu, V. Backman, “An alternate formulation of enhanced backscattering as phase conjugation and diffraction: derivation and experimental observation”, Optics Express,19(13), 11922-11931 (2011).

I. R. Capoglu, C. A. White, J. D. Rogers, A. Taflove, V. Backman, “Numerical Simulation of Partially-Coherent Broadband Optical Imaging Using the FDTD Method”, Optics Letters, 36(9), 1596-1598 (2011).

A. K. Tiwari, S. E. Crawford, A. Radosevich, R. Wali, Y. Stypula, D. P. Kunte, N. Mutyal, S. Ruderman, A. Gomes, M. L. Cornwell, M. De La Cruz, J. Brasky, T. Ward, V. Backman, H. K. Roy,“Neo-Angiogenesis and the Premalignant Micro-Circulatory Augmentation of Early Colon Carcinogenesis”, Cancer Letters, 306(2011), 205–213 (2011).

V. Turzhitsky, A. J. Radosevich, N. N. Mutyal, J. D. Rogers, V. Backman, “Measurement of Optical Scattering Properties with Low-Coherence Enhanced Backscattering Spectroscopy”, JBO, 16(6), 067007, 1-14 (2011).

P. Pradhan, D. Dhwanil, V. Turzhitsky, V. Backman, “Quantification of nanoscale density fluctuations using electron microscopy: Light-localization properties of biological cells”, Applied Physics Lett., 97, 243704, 1-3 (2010).

H. K. Roy, A. J. Gomes, S. Ruderman, V. Turzhitsky, J. D. Rogers, V. Stoyneva, L. K. Bianchi, M. J. Goldberg, Y. L. Kim, E. Yen, A. Kromine, M. Jameel, V. Backman, “Optical Measurement of Rectal Microvasculature as an Adjunct to Flexible Sigmoidosocopy: Gender-Specific Implications”, Cancer Prevention Research, 3(7), 844–851 (2010).

S. Ruderman, A. J. Gomes, V. Stoyneva, J. D. Rogers, A. J. Fought, B. D. Jovanovic, V. Backman, “Analysis of pressure, angle and temporal effects on tissue optical properties from polarization-gated spectroscopic probe measurements”, Biomedical Optics Express, 1(2), 489-499 (2010) PMC3017986.

A.J. Radosevich, V.M. Turzhitsky, N.N. Mutyal, J.D. Rogers, V. Stoyneva, A.K. Tiwari, M. De La Cruz, D.P. Kunte, H.K. Roy, V. Backman, "Depth-resolved measurement of mucosal microvascular blood content using Low-coherence Enhanced Backscattering Spectroscopy", Biomedical Optics Express, 1(4), 1196-1208 (2010) PMC3018078.

V. Turzhitsky, A. Radosevich, J. D. Rogers, A. Taflove,  V. Backman, “A Predictive Model of Backscattering at Subdiffusion Length Scales” , Biomedical Optics Express, 1(3), 1034-1046 (2010) PMC3018048.

H. K. Roy, H. Subramanian, D. Damania, T. Hensing, D. Ray, A. Bogojevic, P. Pradhan, J. Rogers, N. Hasabou, I. Caopglu, V. Backman, “Optical Detection of Buccal Epithelial Nano-Architectural Alterations in Patients Harboring Lung Cancer: Implications for Screening”,Cancer Research, 70(20), 7748-7754 (2010).

N.N. Boustany, S.A. Boppart, V. Backman, “Microscopic Imaging and Spectroscopy with Scattered Light”, Annual Review of Biomedical Engineering, 12, 285–314 (2010).

D. Damania, H. Subramanian, A.K. Tiwari, Y. Stypula, D. Kunte, P. Pradhan, H. Roy, V. Backman, "Role of cytoskeleton in controlling the disorder strength of cellular nanoscale architecture", Biophysical Journal Volume 99, 989–996 (2010).

V. Turzhitsky, J.D. Rogers, N. Mutyal, H. K. Roy, V. Backman, “Characterization of light transport in scattering media at sub-diffusion length scales with Low-coherence Enhanced Backscattering”, IEEE JSTQE, 16(3), 619-626 (2010) (invited paper) PMC2964859.

Capoglu, J. Rogers, A. Taflove, V. Backman, “Accuracy of the Born Approximation in Calculating the Scattering Coefficient of Biological Continuous Random Media”, Optics Letters, 34(17), 2679-2681 (2009) PMC19724530.

J. D. Rogers, I. R. Capoglu, V. Backman, “Nonscalar elastic light scattering from continuous media in the Born approximation”, Optics Letters, 34(12), 1891-1893 (2009) PMC19529738.

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, J.-S. Chang, J. Mohammed, V. Backman, “Nanoscale Cellular Changes in Field Carcinogenesis Detected by Partial Wave Spectroscopy”, Cancer Research, 69(13), 5357-5363 (2009) PMC2802178.

V. Turzhitsky, Y. Liu, N. Hasabou, M. Goldberg, H. K. Roy, V. Backman, R. Brand, “Investigating Population Risk Factors of Pancreatic Cancer by Evaluation of Optical Markers in the Duodenal Mucosa”, Disease Markers, 25, 313-321 (2009) (invited paper) PMC2730822.
Erratum

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, N. Hasabou, P. Pradhan, V. Backman, "Association between Rectal Optical Signatures and Colonic Neoplasia: Potential Applications for Screening", Cancer Research, 69(10), 4476-4483 (2009) PMC2722930.

H. Subramanian, P. Pradhan, Y. Liu, I. Capoglu, J. Rogers, H. Roy, R. Brand and V. Backman, "Partial-wave microscopic spectroscopy detects subwavelength refractive index fluctuations: an application to cancer diagnosis", Optics Letters, 34(4), 518-520 (2009) PMC2701738.

S.-C. Kong, A. Taflove, V. Backman, "Quasi one-dimensional light beam generated by a graded-index microsphere", Optics Express, 17(5), 3722-3731 (2009) PMC2701736.

S.-C. Kong, A. V. Sahakian, A. Taflove, V. Backman, "High-Density Optical Data Storage Enabled by the Photonic Nanojet from a Dielectric Microsphere", JJAP, 48, 03A008, 1-3 (2009).

A. J. Gomes, H. K. Roy, V. Turzhitsky, Y. Kim, J. D. Rogers, M. J. Goldberg, A. Kromine, M. Jameel, V. Backman, “Rectal Mucosal Microvascular Blood Supply Increase is Associated with Colonic Neoplasia”, Clinical Cancer Research, 15(9), 3110-3117 (2009) PMC2745222.

A. Heifetz, S.-C. Kong, A. V. Sahakian, A. Taflove, V. Backman, “Photonic Nanojets”, J. Computational and Theoretical Nanoscience, 6(9), 1979-1992 (2009) (invited paper) PMC2782642.

V. Turzhitsky, A. J. Gomes, Y. L. Kim, Y. Liu, A. Kromine, J. D. Rogers, M. Jameel, H. K. Roy, V. Backman, "Measuring Mucosal Blood Supply in vivo with a Polarization Gating Probe", Applied Optics, 47(32), 6046-6057 (2008) PMC2728617.

H. Subramanian, P. Pradhan, Y. Liu, I. Capoglu, X. Li, J. Rogers, A. Heiftez, D. Kunte, H. K. Roy, A. Taflove, V. Backman, "Optical Methodology for Detecting Histologically Unapparent Nanoscale Consequences of Genetic Alterations in Biological Cells", PNAS, 105(51), 20124-20129 (2008) PMC2629261.

I. R. Capoglu, A. Taflove, V. Backman, "Generation of an incident focused light pulse in FDTD", Optics Express, 16(23), 19208-19220 (2008) PMC2743158.

S. C. Kong, A. V. Sahakian, A. Taflove, V. Backman, “Photonic Nanojet-enabled Optical Data Storage”, Optics Express, 16(18), 13713-13719 (2008).

H. K. Roy, A. Gomes, V. Turzhitsky, M. J. Goldberg, J. Rogers, S. Ruderman, Y. L. Kim, A. Kromine, R. E. Brand, M. Jameel, N. Hasabou, V. Backman, “Spectroscopic Microvascular Blood Detection from the Endoscopically Normal Colonic Mucosa: Biomarker for Neoplasia Risk”, Gastroenterology, 135(4), 1069-1078 (2008) (cover article), (editorial page).

S. C. Kong, A. V. Sahakian, A. Heifetz, A. Taflove, V. Backman, "Robust Detection of Deeply Subwavelength Pits in Simulated Optical Data-Storage Disks Using Photonic Jets", Applied Physics Letters, 92(21), 211102, 1-3(2008) (cover article).

H. K. Roy, V. Turzhitsky, Y. L. Kim, Y. Liu, M. J. Goldberg, R. E. Brand, N. Hasabou, M. Jameel, and V. Backman, “Spectral Slope from the Endoscopically-Normal Mucosa Predicts Concurrent Colonic Neoplasia: A Pilot Ex-Vivo Clinical Study”, Diseases of Colon and Rectum, 51, 1381-1386 (2008) PMC2913285.

S. C. Kong, J. J. Simpson, A. Taflove, Vadim Backman,“ADE-FDTD Scattered-Field Formulation for Dispersive Materials", IEEE Microwave and Wireless Components Letters, 18(1), 4-6 (2008) PMC2763393.

A. Heifetz, A. Taflove, V. Backman, "Subdiffraction optical resolution of a gold nanosphere located within the nanojet of a Mie-resonant dielectric microsphere", Optics Express , 15 (25), 17334-17342 (2007).

H. K. Roy, R. K. Wali, Y. Kim, Y. Liu, J. Hart, D. P. Kunte, J. L. Koetsier, M. J. Goldberg, V. Backman, "Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis", FEBS , 581 (20), 3857-3862 (2007).

A. Kaushiva, V. M Turzhitsky, V. Backman, G. A. Ameer, "A biodegradable vascularizing membrane: A feasibility study", Acta Biomaterialia, 3 (5), 631-642 (2007).

H. Subramanian, P. Pradhan, Y. Kim, V. Backman, "Penetration depth of low-coherence enhanced backscattering of light in sub-diffusion regime;, Phys.Rev. E, 75, 041914, 1-9 (2007).

Y. Liu, R. E. Brand, V. Turzhitsky, Y. L. Kim, H. K. Roy, N. Hasabou, C. Sturgis, D. Shah, C. Hall, V. Backman, "Optical Markers in Duodenal Mucosa Predict the Presence of Pancreatic Cancer", Clinical Cancer Research, 13(15), 4392-4399 (2007) (feature article).

National Science Foundation Press Release: http://nsf.gov/news/news_summ.jsp?cntn_id=109781&org=NSF&from=news


X. Li, A. Taflove, V. Backman,"Anomalous Oscillations in the Spectra of Light Backscattered by Inhomogeneous Microparticles", Phys. Rev. E, 75, 037601, 1-4 (2007).

R. Figueiredo, V. Backman, Y. Liu, J. Paladugula,  "Architecture and Performance of a Grid-enabled Lookup-based Biomedical Optimization Application: Light Scattering Spectroscopy", IEEE Transactions on Information Technology in BioMedicine , 11 (2), 170-178 (2007).

J. Allen, Y. Liu, Y. L. Kim, V. M. Turzhitsky, V. Backman, G. A. Ameer,"Spectroscopic translation of cell-material interactions", Biomaterials , 28, 162-174 (2007).

H.K. Roy, V. Backman, M. Goldberg, "Colon Cancer Screening: The Good, the Bad and the Ugly", Archives of Internal Medicine, 166, 2177-2179 (2006) (editorial).

L. A. Marcelino, V. Backman, A. Donaldson, C. Steadman, J. Thompson, S. Pacocha-Preheim, C. Lien, E. Lim, D. Veneziano, M. F. Polza, "Accurately quantifying low-abundant targets amid similar sequences by revealing hidden correlations in oligonucleotide microarray data", PNAS, 103(37), 13629-13634 (2006).

A. Heifetz, K. Huang, A. V. Sahakian, X. Li, A. Taflove, V. Backman, "Experimental Confirmation of  Backscattering Enhancement Induced by a Photonic Jet", App. Phys. Lett., 89, 221118, (2006).

X. Xia, Y. Liu, V. Backman, G. A. Ameer, "Engineering sub-100 nm multi-layer nanoshells", Nanotechnology, 17, 5435-5440 (2006).

Y. L. Kim, P. Pradhan, M. H. Kim, and V. Backman, “Circular Polarization Memory Effect in Low-coherence Enhanced Backscattering of Light”, Optics Letters, 31, 2744-2746 (2006).

J. Gong, B. Liu, Y. Kim, X. Li, V. Backman, “Optimal Spectral Reshaping  for Resolution Improvement in Optical Coherence Tomography”, Optics Express, 14 (13), 5909-5915 (2006).

H. Subramanian, P. Pradhan, Y. Kim, Y. Liu, X. Li, and V. Backman, “Modeling low-coherence enhanced backscattering using Monte Carlo simulation”, Applied Optics, Vol. 45, No. 24, 6292-6300 (2006).

Y. L. Kim, Y. Liu, P. Pradhan, X. Li, V. Backman,“Origin of low-coherence enhanced backscattering”, Optics Letters, Vol 31, No 10, 1459-1461 (2006). 

S. Tseng, A. Taflove, D. Maitland, V. Backman, “Pseudospectral Time Domain Simulations of Multiple Light Scattering in Three-Dimensional  Macroscopic Random Media”, Radio Science, 41, RS4009, doi:10.1029/2005RS003408 (2006).

Y. L. Kim, V. Turzhitsky, Y. Liu, H. K. Roy, R. K. Wali, H. Subramanian, P. Pradhan, V. Backman,“Low-coherence enhanced backscattering: review of principles and applications for colon cancer screening”, J. Biomed. Optics, 11(4), 041125-1-10 (2006).

S. Tseng, A. Taflove, D. Maitland, V. Backman, J. T. Walsh, “Extracting Geometrical Information of Closely Packed Random Media from Multiply Scattered Light via a Cross-correlation Analysis”, IEEE Antenna and Wireless Propagation Letters, 5, 91-94 (2006).

H. K. Roy, Y. L. Kim, Y. Liu, R. K. Wali, M. J. Goldberg, V. Turhitsky, J. Horwitz, V. Backman,“Risk Stratification of Colon Carcinogenesis through Enhanced Backscattering Spectroscopy Analysis of the Uninvolved Colonic Mucosa”, Clinical Cancer Research, 19(3), 961-968 (2006).

Z. Chen, A. Taflove, V. Backman, “Highly Efficient Optical Coupling and Transport Phenomena in Chains of Dielectric Microspheres”, Optics Letters, 31(3), 389-391 (2006).

M. P. Siegel, Y. L. Kim, H. Roy, R. Wali, V. Backman, “Assessment of Blood Supply in Superficial Tissue by Polarization-Gated Elastic Light- Scattering Spectroscopy”, Applied Optics, 40(2), 335-342 (2006).

Z. Chen, X. Li, A. Taflove, V. Backman, “Super-enhanced Backscattering of Light by Nanoparticles”, Optics Letters, 31(2), 196-198 (2006).

H. K.Roy, D. P.Kunte, J. L. Koetsier , J. Hart, Y. L.Kim, Y. Liu, M. Bissonnette, M. Goldberg, V. Backman, R. K. Wali, “Chemoprevention of colon carcinogenesis by polyethylene glycol: suppression of epithelial proliferation via modulation of SNAIL/B-catenin signaling”, Molecular Cancer Therapeutics, 5(8), 2060-2069 (2006).

Z. Chen, X. Li, A. Taflove, and V. Backman, “Backscattering  Enhancement of Light by Nanoparticles Positioned in Localized Optical Intensity Peaks”, Applied Optics, 45(4), 633-638 (2006).

M. Hunter, V. Backman, G. Popescu, M. Kalashnikov, C. W. Boone, A. Wax, V. Gopal, K. Badizadegan, G. D. Stoner, M. S. Feld,  “Tissue Self-Affinity and Polarized Light Scattering in the Born Approximation: A New Model for Precancer Detection”, Phys. Rev. Lett, 97(13), 138102, 1-4 (2006).

X. Li, A. Taflove, V. Backman,“Recent Progress in Exact and Reduced-order Modeling of Light-scattering Properties of Complex Structures”, IEEE JSTQE, 11(4), 759-765 (2005).

Y. Liu, X. Li, Y. L. Kim, V. Backman,“Elastic Backscattering Spectroscopic Microscopy”, Optics Letters, 30(18), 2445-2447 (2005).

H. K. Roy, Y. Kim, R. K. Wali, Y. Liu, J. Koetsier, A. Kromine, D. P. Kunte, M. J. Goldberg, V. Backman,“Spectral Markers in Preneoplastic Intestinal Mucosa: An Accurate Predictor of Tumor Risk in the MIN Mouse”, Cancer Epidemiology, Biomarkers & Prevention, 14(7), 1639-1645 (2005).

X. Li, Z. Chen, A. Taflove, V. Backman,“Optical Analysis of Nanoparticles via Enhanced Backscattering Facilitated by 3-D Photonic Nanojets”, Optics Express, 13(2), 526-533 (2005).

Y. Liu, Y. Kim, X. Li, V. Backman,“Investigation of Depth Selectivity of Polarization Gating for Tissue Characterization”, Optics Express, 13(2), 601-611 (2005).

X. Li, A. Taflove, V. Backman,“Quantitative analysis of depolarization of backscattered light by stochastically inhomogeneous dielectric particles”, Optics Letters, 30(8), 902-904 (2005).

Y. L. Kim, Y. Liu, V. M. Turzhitsky, R. Wali, H. Roy, and V. Backman,“Depth-resolved Low-coherence Enhanced Backscattering ”, Optics Letters, 30(7), 741-743 (2005).

Y. Liu, Y. Kim, V. Backman,“Development of a Bioengineered Tissue Model and Its Application in the Investigation of the Depth Selectivity of Polarization Gating”, Applied Optics, 44(12) 2288-2299 (2005).

X. Li, A. Taflove, V. Backman,“Modified FDTD Near-to-Far Field Transformation for Improved Backscattering Calculation of Strongly Forward-Scattering Objects”, IEEE Antennas and Wireless Propagation Lett., 4, 35-38 (2005).

S. H. Tseng, A. Taflove, D. Maitland, V. Backman, J. T. Walsh, Jr., “Investigation of the Noise-like Structures of the Total Scattering Cross-section for Random Media”, Optics Express, 13(16), 6127-6132 (2005).

K. Chen, Y. Kim, A. Taflove, V. Backman,“Self-Assembled Patterns of Nanospheres with Symmetries from Submicrons to Centimeters”, Applied Physics Letters, 86, 033101, 1-3 (2005). (Cover article.)

R. K. Wali, H. K. Roy, Y. L. Kim, Y. Liu, J. L. Koetsier, D. P. Kunte, M. J. Goldberg, V. Turzhitsky, V. Backman, “Increased Microvascular Blood Content is an Early Event in Colon Carcinogenesis”, Gut, 54, 654-660 (2005).

S. H. Tseng, J. H. Greene, A. Taflove, D. Maitland, V. Backman, J. T. Walsh, “Exact solution of Maxwell's equations for optical interactions with a macroscopic random medium: addendum”, Optics Letters, 30(1), 56-57 (2005).

Y. L. Kim, Y. Liu, R.K. Wali, H.K. Roy, V. Backman,“Low-Coherent Backscattering Spectroscopy for Tissue Characterization”, Applied Optics, 44(3), 366-377 (2005).

K. Chen, Y. Liu, G. Ameer, and V. Backman,“Optimal design of structured nanospheres for ultrasharp light-scattering resonances as molecular imaging multilabels”, J. Biomedical Optics, 10(2), 024005, 1-6 (2005).

S. H. Tseng, Y. L. Kim, A. Taflove, D. Maitland, V. Backman, J. T. Walsh, Jr.,“Simulation of enhanced backscattering of light by numerically solving Maxwell’s equations without heuristic approximations”, Optics Express, 13(10), 3666-3672 (2005).

X. Li, Z. Chen, A. Taflove, V. Backman,“Equiphase-sphere approximation for light scattering by stochastically inhomogeneous microparticles”, Phys. Rev. E, 70, 056610, 1-8 (2004).

Y. L. Kim, Y. Liu, H. K. Roy, R. K. Wali, and V. Backman,“Coherent Backscattering Spectroscopy”, Optics Letters, 29 (16), 1906-1908 (2004).

X. Li, Z. Chen, A. Taflove, and V. Backman,“Equiphase-sphere approximation for analysis of light scattering by arbitrarily-shaped nonspherical particles”, Applied Optics, 43(23), 4497-4505 (2004).

H. K. Roy, P. Iversen, J. Hart, Y. Liu, J. L. Koetsier, Y. Kim, D. P. Kunte, M. Madugula, V. Backman, R. K. Wali, “Down-regulation of SNAIL Suppresses MIN Mouse Tumorigenesis: Modulation of Apoptosis, Proliferation and Fractal Dimension”, Molecular Cancer Therapeutics, 3(9), 1159-1165 (2004).