Faculty Directory
Thomas Hope

Professor of Cell and Molecular Biology

Professor of Biomedical Engineering


Robert H Lurie Medical Research Center 9th Floor
303 E Superior
Chicago, IL 60611

Email Thomas Hope


Hope Lab


Biomedical Engineering


PhD: University Of California-Berkeley, Immunology (1988)

Postdoctoral Fellowship: University of California, San Francisco (1992)

Research Interests

My laboratory studies various aspects of HIV science taking a cell biology approach. The centerpiece of our approach is microscopic imaging, which provides important information relating to context and dynamics of biological functions. To study HIV, the Hope lab has developed a series of techniques and tools that allow the fluorescent labeling of HIV particles or viral proteins and the identification of infected cells. We can now follow virions and infected cells from the tissue culture dish to whole animal models. For more than a decade we have combined this cell biology approach, supplemented with molecular biology, biochemistry, and genetics to study various aspects of HIV from virus entry and assembly, to defining the earliest steps of the sexual transmission of HIV. The studies to define the mechanisms of transmission have recently redirected a large aspect of the lab to HIV prevention science, including vaccine and microbicide research.

Selected Publications

The cyclosporin a washout assay to detect HIV-1 uncoating in infected cells
Hulme AE, Hope TJ.
Methods in Molecular Biology. 2014 Jan;1087:37-46.doi:10.1007/978-1-62703-670-2-4.
ISSN: 10643745

Differential Binding of IgG and IgA to Mucus of the Female Reproductive Tract
Fahrbach KM, Malykhina O, Stieh DJ, Hope TJ.
PLoS ONE. 2013 Oct 2;8(10):doi:10.1371/journal.pone.0076176.
PMID: 24098437 ISSN: 19326203

Using antiubiquitin antibodies to probe the ubiquitination state within rhTRIM5α cytoplasmic bodies
Danielson CM, Hope TJ.
AIDS Research and Human Retroviruses. 2013 Oct;29(10):1373-1385.doi:10.1089/aid.2013.0029.
ISSN: 08892229

New paradigms for functional HIV-specific nonneutralizing antibodies
Forthal D, Hope TJ, Alter G.
Current Opinion in HIV and AIDS. 2013 Sep;8(5):393-401.doi:10.1097/COH.0b013e328363d486.
PMID: 23924999 ISSN: 1746630X

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