News & EventsDepartment Events
Events
-
Nov5
EVENT DETAILS
Title: The Dynamics of Particles with Ligand-receptor Contacts
Speaker: Miranda Holmes-Cerfon, The University of British Columbia
Abstract: One way to glue objects together at the nanoscale or microscale is by ligand-receptor interactions, where short sticky hair-like ligands stick to receptors on another surface, much like velcro on the nanoscale. Such interactions are common in biological systems, such as white blood cells, virus particles, cargo in the nuclear pore complex, etc, and they are also useful in materials science, where coating colloids with single-stranded DNA creates particles with programmable interactions. In these systems, the ligand-receptor interactions not only hold particles together, but also influence their dynamics. How do such particles move? Do they “roll” on each others’ surfaces, as is commonly thought? Or could they slide? And does it matter? In this talk I will introduce our modelling and experimental efforts aimed at understanding the coarse-grained dynamics of particles with ligand-receptor interactions. Our models predict these interactions can change the particles' effective diffusion by orders of magnitude. Our experiments, using DNA-coated colloids, verify this dramatic dynamical slowdown, but also show other dynamical features not yet captured by our models, which suggest new avenues for exploration.
Zoom: https://northwestern.zoom.us/j/91351360985
-----
To subscribe to the Applied Mathematics Colloquia List send a message to LISTSERV@LISTSERV.IT.NORTHWESTERN.EDU with the command:
add esam-seminar Youremail Firstname Lastname
TIME Tuesday, November 5, 2024 at 11:15 AM - 12:15 PM
LOCATION M416, Technological Institute map it
CONTACT Ted Shaeffer ted.shaeffer@northwestern.edu EMAIL
CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)
-
Nov12
EVENT DETAILS
Title: Carving Circuits from Correlative Connectomics
Speaker: Mariela Petkova, Harvard University
Abstract: Tracing the wiring diagram of a neural circuit is a powerful approach to test
computational models of brain function. Connectomics – the mapping of
neurons and their connections in the brain – poses formidable technical and
conceptual challenges. The former entails the acquisition and reduction of
vast amounts of electron microscopy image data to connectivity matrices,
achieved through multi-year, multi-team collaborative efforts. The latter
challenge is the problem of coarse-graining the connectivity matrices to
neural circuits which exhibit neural activity and function. I will describe both
challenges in the context of mapping the nervous system of a small
vertebrate – the larval zebrafish. In the same animal, we pair electron
microscopy with functional information from light microscopy to interrogate
neural circuit models for animal behavior from sensory inputs to motor output.Zoom: https://northwestern.zoom.us/j/94241764594
-----
To subscribe to the Applied Mathematics Colloquia List send a message to LISTSERV@LISTSERV.IT.NORTHWESTERN.EDU with the command:
add esam-seminar Youremail Firstname Lastname
TIME Tuesday, November 12, 2024 at 11:15 AM - 12:15 PM
LOCATION M416, Technological Institute map it
CONTACT Ted Shaeffer ted.shaeffer@northwestern.edu EMAIL
CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)
-
Nov19
EVENT DETAILS
Title: Reengineering Somite Segmentation without the Vertebrate Segmentation Clock
Speaker: Ertugrul Ozbudak, Northwestern University
Abstract: Somitogenesis establishes the segmental pattern of the vertebral column. A molecular segmentation clock sets the pace of somite formation while a spatial gradient of ERK activity instructs segment boundary positions. However, how cells are primed to form a segment boundary at discrete locations and how the clock and gradient are mechanistically integrated were unclear. We developed transgenic reporters for the segmentation clock and the gradient in zebrafish embryos. We show that the segmentation clock periodically inhibits the gradient, therefore projecting its oscillation onto the gradient. Pulsatile inhibition of the gradient can fully substitute for the role of the clock, and other targets of the clock are dispensable for sequential segmentation. We propose a “Clock-dependent Oscillatory Gradient (COG)” model in which the clock periodically triggers discrete jumps of the positional information. Computational simulations of the COG model explain all experimental observations; the new model effectively replaces a long-standing textbook model.
Zoom: https://northwestern.zoom.us/j/95679444293
-----
To subscribe to the Applied Mathematics Colloquia List send a message to LISTSERV@LISTSERV.IT.NORTHWESTERN.EDU with the command:
add esam-seminar Youremail Firstname Lastname
TIME Tuesday, November 19, 2024 at 11:15 AM - 12:15 PM
LOCATION M416, Technological Institute map it
CONTACT Ted Shaeffer ted.shaeffer@northwestern.edu EMAIL
CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)
-
Dec7
EVENT DETAILS
Fall classes end
TIME Saturday, December 7, 2024
CONTACT Office of the Registrar nu-registrar@northwestern.edu EMAIL
CALENDAR University Academic Calendar
-
Dec14
EVENT DETAILS
The ceremony will take place on Saturday, December 14 in Pick-Staiger Concert Hall, 50 Arts Circle Drive.
*No tickets required
TIME Saturday, December 14, 2024 at 4:00 PM - 6:00 PM
LOCATION Pick-Staiger Concert Hall map it
CONTACT Andi Joppie andi.joppie@northwestern.edu EMAIL
CALENDAR McCormick School of Engineering and Applied Science