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  • Nov
    19

    Appl Math: Ertugrul Ozbudak on "Reengineering Somite Segmentation without the Vertebrate Segmentation Clock"

    McCormick-Engineering Sciences and Applied Mathematics (ESAM)

    11:15 AM M416, Technological Institute

    EVENT DETAILS

    Title: Reengineering Somite Segmentation without the Vertebrate Segmentation Clock

    Speaker: Ertugrul Ozbudak, Northwestern University

    Abstract: Somitogenesis establishes the segmental pattern of the vertebral column. A molecular segmentation clock sets the pace of somite formation while a spatial gradient of ERK activity instructs segment boundary positions. However, how cells are primed to form a segment boundary at discrete locations and how the clock and gradient are mechanistically integrated were unclear. We developed transgenic reporters for the segmentation clock and the gradient in zebrafish embryos. We show that the segmentation clock periodically inhibits the gradient, therefore projecting its oscillation onto the gradient. Pulsatile inhibition of the gradient can fully substitute for the role of the clock, and other targets of the clock are dispensable for sequential segmentation. We propose a “Clock-dependent Oscillatory Gradient (COG)” model in which the clock periodically triggers discrete jumps of the positional information. Computational simulations of the COG model explain all experimental observations; the new model effectively replaces a long-standing textbook model.

    Zoom: https://northwestern.zoom.us/j/95679444293

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    TIME Tuesday, November 19, 2024 at 11:15 AM - 12:15 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Ted Shaeffer    ted.shaeffer@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)

  • Sep
    8

    Welcome & Breakfast for New McCormick PhD Students

    McCormick School of Engineering and Applied Science

    9:00 AM LR2 & Tech East Plaza, Technological Institute

    EVENT DETAILS

    TIME Monday, September 8, 2025 at 9:00 AM - 10:00 AM

    LOCATION LR2 & Tech East Plaza, Technological Institute    map it

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    CONTACT Andi Joppie    andi.joppie@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Sep
    12

    New Undergraduate Fall 2025 Registration

    University Academic Calendar

    All Day

    EVENT DETAILS

    TIME Friday, September 12, 2025

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Sep
    15

    Welcome & Luncheon for New Full-time Graduate Students

    McCormick School of Engineering and Applied Science

    11:00 AM Ryan Auditorium & Tech East Plaza, Technological Institute

    EVENT DETAILS

    TIME Monday, September 15, 2025 at 11:00 AM - 12:30 PM

    LOCATION Ryan Auditorium & Tech East Plaza, Technological Institute    map it

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    CONTACT Andi Joppie    andi.joppie@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Sep
    16

    Fall Classes Begin. Change of Registration (Drop/Add) Late registration for returning students begins

    University Academic Calendar

    All Day

    EVENT DETAILS

    TIME Tuesday, September 16, 2025

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar