Faculty Directory
Danielle Tullman-Ercek

Professor of Chemical and Biological Engineering

Director, Master of Science in Biotechnology Program

Contact

2145 Sheridan Road
Silverman 3619
Evanston, IL 60208-3109

847-491-7043Email Danielle Tullman-Ercek

Website

Tullman-Ercek Lab


Departments

Chemical and Biological Engineering

Affiliations

Master of Biotechnology Program

PhD Program in Interdisciplinary Biological Sciences


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Education

Ph.D Chemical Engineering, University of Texas - Austin, Austin, TX

B.S. Chemical Engineering, Illinois Institute of Technology, Chicago, IL


Research Interests

My group is interested in controlling the movement of materials across biological membranes, with a goal of enabling and enhancing the production of pharmaceuticals, biofuels, and materials in microbes. Manipulating the transport of electrons, small molecules, and even signals across these cellular boundaries is a vital component of most synthetic biology applications, and we are developing the tools and methods to engineer membrane proteins and other protein superstructures to meet this grand challenge.



Selected Publications

1. Chen Y., Wang Q., Mills C.E., Kann J.G., Shull KR, Tullman-Ercek D., Wang M. (2021) “High-Throughput Screening Test for Adhesion in Soft Materials Using Centrifugation.” ACS Central Science 7(7):1135-1143. doi: 10.1021/acscentsci.1c00414.

2. Li Y., Kennedy N.W., Li S., Mills C.E., Tullman-Ercek D.*, Olvera de la Cruz M.* (2021) “Computational and experimental approaches to controlling bacterial microcompartment assembly.” ACS Central Science 7(4):658-670. doi: 10.1021/acscentsci.0c01699.

3. Kennedy N.W., Ikonomova S.P., Slininger Lee M., Raeder H.W., Tullman-Ercek D. (2021) “Self-assembling Shell Proteins PduA and PduJ have Essential and Redundant Roles in Bacterial Microcompartment Assembly.” J. Molecular Biology 433(2):166721. doi: 10.1016/j.jmb.2020.11.020.

4. Burdette L.A., Wong H.T., Tullman-Ercek D. (2021) “An optimized growth medium for increased recombinant protein secretion titer via the type III secretion system.” Microb Cell Factories 20(1):44. doi: 10.1186/s12934-021-01536-z.

5. Hartman E.C., Jakobson C.M., Favor A.H., Benedicto E.A., Francis M.B., Tullman-Ercek D. (2018) “Quantitative characterization of all single amino acid variants of a viral capsid-based drug delivery vehicle.” Nature Comm. 9(1): 1385.

6. Slininger Lee M.F., Jakobson C.M., Tullman-Ercek D. (2017) “Evidence for Improved Encapsulated Pathway Behavior in a Bacterial Microcompartment through Shell Protein Engineering.” ACS Synth. Biol. 6(10):1880-1891. PMID: 28585808.

7. Glasgow A.A., Wong H.T., Tullman-Ercek D. (2017) “A secretion-amplification role for Salmonella enterica translocon protein SipD.” ACS Synth. Biol. 6(6):1006-1015. PMID: 28301138.

8. Asensio M., Morella N., Jakobson C.M., Hartman E.C., Glasgow J.E., Sankaran B., Zwart P.H., Tullman-Ercek D. (2016) “A single-point mutation in the capsid protein alters the assembled geometry of the bacteriophage MS2 capsid.” Nano Letters 16(9):5944-50. DOI: 10.1021/acs.nanolett.6b02948. PMID: 27549001.