Faculty Directory
Arthur Prindle

Assistant Professor of Chemical and Biological Engineering and (by courtesy) Biomedical Engineering

Assistant Professor of Biochemistry and Molecular Genetics

Contact

2145 Sheridan Road
Tech
Evanston, IL 60208-3109

312-503-4344 Email Arthur Prindle

Website

Prindle Lab

Departments

Chemical and Biological Engineering

Education

Ph.D., Bioengineering, University of California, San Diego, CA

B.S., Chemical Engineering, with honors, California Institute of Technology, Pasadena, CA

Research Interests

We are interested in understanding how molecular and cellular interactions give rise to collective behaviors in microbial communities. We use synthetic biology, quantitative microscopy, and microfluidics to directly investigate the molecular mechanisms behind how cells communicate across broad spatial and temporal scales. Our goal is to apply these principles to develop new synthetic biology approaches to biomedical problems through microbiome engineering.

Selected Publications

Yang CY, Bialecka-Fornal M, Weatherwax C, Larkin J, Prindle A, Liu J, Garcia-Ojalvo J, Süel G. Encoding spatial memory within a bacterial biofilm community. Cell Systems (2020).

Martinez-Corral R, Liu J, Prindle A, Süel G, Garcia-Ojalvo J. Metabolic basis of brain-like electrical signaling in bacterial communities. Philosophical Transactions B (2019).

Larkin J, Zhai X, Kikuchi K, Redford S, Prindle A, Liu J, Greenfield S, Walczak A, Garcia-Ojalvo J, Mugler A, Süel G. Signal percolation within a bacterial community. Cell Systems (2018).

Lee D, Prindle A, Liu J, Süel G. Electrochemical communication in biofilms. Cell (2017).

Liu J, Martinez-Corral R, Prindle A, Lee D, Larkin J, Gabalda-Sagarra M, Garcia-Ojalvo J, Süel G. Coupling between distant biofilms and emergence of nutrient time-sharing. Science (2017).

• Commentary: Gordon V. Coupling and sharing when life is hard. Science (2017).

• Commentary: Starling S. Communities in sync. Nature Reviews Microbiology (2017).

• Commentary: Libby EA, Dworkin J. Habits of highly effective biofilms: Ion signaling. Molecular Cell (2017).

Humphries, J, Xiong L, Liu J, Prindle A, Yuan F, Arjes HA, Tsimring L, Süel G. Species-independent attraction to biofilms through electrical signals. Cell (2017).

• Commentary: Huang KC. Staying in touch while on the go. Cell (2017).

• Commentary: York A. Shocking biofilms. Nature Reviews Microbiology (2017).

Din MO, Danino T, Prindle A, Skalak M, Selimkhanov J, Allen K, Julio E, Atolia E, Tsimring L, Bhatia SN, Hasty J. Synchronized cycles of bacterial lysis for in vivo delivery. Nature (2016).

• Commentary: Zhou S. Bacteria synchronized for drug delivery. Nature (2016).

Prindle A, Liu J, Asally M, Ly S, Garcia-Ojalvo J, Süel G. Ion channels enable electrical communication in bacterial communities. Nature (2015).

• Commentary: Beagle SD, Lockless SW. Electrical signalling goes bacterial. Nature (2015).

• Commentary: VanHook AM. Exciting times for biofilms. Science Signaling (2015).

• Commentary: Nunes-Alves C. Electrifying long-range signalling. Nature Reviews Microbiology (2015).

• Commentary: Chang S. An eye on bacterial communication. Physics Today (2015).