Faculty Directory
Julius Lucks

Professor of Chemical and Biological Engineering

Contact

2145 Sheridan Road
Tech E154
Evanston, IL 60208-3109

Email Julius Lucks

Website

Lucks Lab

Centers

Center for Synthetic Biology

Departments

Chemical and Biological Engineering

Affiliations

PhD Program in Interdisciplinary Biological Sciences

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Education

Miller Fellow Postdoctoral Associate, University of California, Berkeley, CA

Ph.D., Chemical Physics, Harvard University, Cambridge, MA

M.S., Chemical Physics, Harvard University, Cambridge, MA

M.Phil., Chemistry, University of Cambridge, Cambridge, UK

B.S., Chemistry, University of North Carolina, Chapel Hill, NC


Research Interests

Our research has led to fundamental contributions to our understanding of the molecular principles that enable biological systems to sense and adapt to changing environments, and to understanding how we can use these principles to engineer synthetic biological systems that benefit humankind. A focal point of our work is RNA – a fundamental component of all living systems that enacts genetic, regulatory and catalytic functions by folding into intricate shapes within cells. Through development of high throughput RNA structure/function measurement technologies, we have discovered new ways in which the complexity of RNA folding can be distilled into simple rules, and have shown that these rules can be used to design new synthetic RNAs to control genetic processes. This discovery-to-design research paradigm is now making possible a whole new toolkit based on synthetic biotechnology principles that has the potential to transform our world through tackling global challenges, most recently through our development of low-cost, on-demand diagnostic technologies that can detect water contaminants and pathogens.


Selected Publications

  1. A. M. Yu, P. M. Gasper, L. Cheng, L. B. Lai, S. Kaur, V. Gopalan, A. A. Chen, J. B. Lucks (2021). "Computationally reconstructing cotranscriptional RNA folding from experimental data reveals rearrangement of non-native folding intermediates." Molecular Cell doi: 10.1016/j.molcel.2020.12.017.
  2. J. K. Jung, K. K. Alam, M. S. Verosloff, D. A. Capdevila, M. Desmau, P. R. Clauer, J. W. Lee, P. Q. Nguyen, P. A. Pasten, S. J. Matiasek, J.-F. Gaillard, D. P. Giedroc, J. J. Collins, J. B. Lucks (2020). "Cell-free biosensors for rapid detection of water contaminants." Nature Biotechnology. doi: 10.1038/s41587-020-0571-7.
  3. W. Thavarajah, A. D. Silverman, M. S. Verosloff, N. Kelley-Loughnane, M. C. Jewett, J. B. Lucks (2019). "Point-of-use detection of environmental fluoride via a cell-free riboswitch-based biosensor." ACS Synthetic Biology. doi: 10.1021/acssynbio.9b00347.
  4. E. J. Strobel, L. Chang, K. Berman, P. D. Carlson, J. B. Lucks (2019). “A ligand-gated strand displacement mechanism for ZTP riboswitch transcriptional control.” Nature Chemical Biology. doi:10.1038/s41589-019-0382-7.
  5. A. Y Xu, A. M Yu, J. B. Lucks, N. Bagheri (2019). "DUETT quantitatively identifies known and novel events in nascent RNA structural dynamics from chemical probing data." Bioinformatics. doi: 10.1093/bioinformatics/btz449.
  6. E. J. Strobel, A. M Yu, J. B. Lucks (2018). "High-throughput determination of RNA structures." Nature Reviews Genetics, 19, 615-634.
  7. K. E. Watters, E. J. Strobel, A. M Yu, J. T. Lis, J. B. Lucks (2016). “Cotranscriptional Folding of a Riboswitch at Nucleotide Resolution”, Nature Structural and Molecular Biology, 23, 1124-1131.
  8. K. E. Watters, T. R. Abbott, J. B. Lucks (2015). “Simultaneous characterization of cellular RNA structure and function with in-cell SHAPE-Seq,” Nucleic Acids Research, 44, e12.
  9. J. Chappell, M. K. Takahashi, J. B. Lucks (2015). “Creating small transcription activating RNAs,” Nature Chemical Biology, 11, 214-220.
  10. M. K. Takahashi, J. Chappell, C. A. Hayes, Z. Z. Sun, J. Kim, V. Singhal, K. J. Spring, S. Al-Khabouri, C. P. Fall, V. Noireaux, R. M. Murray, J. B. Lucks (2015). “Rapidly characterizing the fast dynamics of RNA genetic circuitry with cell-free transcription-translation (TX-TL) systems,” ACS Synthetic Biology, 4, 503-515.