Faculty Directory

Igor Efimov

Professor of Biomedical Engineering

Professor of Medicine (Division of Cardiology)

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The Efimov Lab

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Research Interests

Igor Efimov’s Research Interests: My Cardiovascular Engineering laboratory focuses on the physiological mechanisms of cardiovascular disease and on developing novel therapies for heart diseases with an emphasis on heart rhythm disorders and heart failure. Two engineering strategies are pursued: (1) development of novel implantable, interventional, and wearable bioelectronics for real-time device-based diagnostics and therapy of heart diseases and sudden cardiac death; (2) development of novel approaches to bioinformatics and machine learning to diagnose early stages or predisposition to heart disease and to guide the development of novel therapies. 

Selected Publications

• Aras, Kedar; Gams, Anna; Faye, Ndeye Rokhaya; Brennan, Jaclyn; Goldrick, Katherine; Li, Jinghua; Zhong, Yishan; Chiang, Chia Han; Smith, Elizabeth H.; Poston, Megan D.; Chivers, Jacqueline; Hanna, Peter; Mori, Shumpei; Ajijola, Olujimi A.; Shivkumar, Kalyanam; Hoover, Donald B.; Viventi, Jonathan; Rogers, John A.; Bernus, Olivier; Efimov, Igor R., Electrophysiology and Arrhythmogenesis in the Human Right Ventricular Outflow Tract, Circulation: Arrhythmia and Electrophysiology (2022).
• Pei, J.; Schuldt, M.; Nagyova, E.; Gu, Z.; el Bouhaddani, S.; Yiangou, L.; Jansen, M.; Calis, J. J.A.; Dorsch, L. M.; Blok, C. Snijders; van den Dungen, N. A.M.; Lansu, N.; Boukens, B. J.; Efimov, I. R.; Michels, M.; Verhaar, M. C.; de Weger, R.; Vink, A.; van Steenbeek, F. G.; Baas, A. F.; Davis, R. P.; Uh, H. W.; Kuster, D. W.D.; Cheng, C.; Mokry, M.; van der Velden, J.; Asselbergs, F. W.; Harakalova, M., Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations, Clinical Epigenetics (2021).
• Zhu, Ching; Rajendran, Pradeep S.; Hanna, Peter; Efimov, Igor R.; Salama, Guy; Fowlkes, Charless C.; Shivkumar, Kalyanam, High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zones, JCI Insight (2022).
• Sands, Gregory B.; Ashton, Jesse L.; Trew, Mark L.; Baddeley, David; Walton, Richard D.; Benoist, David; Efimov, Igor R.; Smith, Nicolas P.; Bernus, Olivier; Smaill, Bruce H., It's clearly the heart! Optical transparency, cardiac tissue imaging, and computer modelling, Progress in Biophysics and Molecular Biology (2022).
• Choi, Yeon Sik; Jeong, Hyoyoung; Yin, Rose T.; Avila, Raudel; Pfenniger, Anna; Yoo, Jaeyoung; Lee, Jong Yoon; Tzavelis, Andreas; Lee, Young Joong; Chen, Sheena W.; Knight, Helen S.; Kim, Seungyeob; Ahn, Hak Young; Wickerson, Grace; Vázquez-Guardado, Abraham; Higbee-Dempsey, Elizabeth; Russo, Bender A.; Napolitano, Michael A.; Holleran, Timothy J.; Razzak, Leen Abdul; Miniovich, Alana N.; Lee, Geumbee; Geist, Beth; Kim, Brandon; Han, Shuling; Brennan, Jaclyn A.; Aras, Kedar; Kwak, Sung Soo; Kim, Joohee; Waters, Emily Alexandria; Yang, Xiangxing; Burrell, Amy; Chun, Keum San; Liu, Claire; Wu, Changsheng; Rwei, Alina Y.; Spann, Alisha N.; Banks, Anthony; Johnson, David; Zhang, Zheng Jenny; Haney, Chad R.; Jin, Sung Hun; Sahakian, Alan Varteres; Huang, Yonggang; Trachiotis, Gregory D.; Knight, Bradley P.; Arora, Rishi K.; Efimov, Igor R.; Rogers, John A., A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy, Science (2022).
• Yang, Quansan; Wei, Tong; Yin, Rose T.; Wu, Mingzheng; Xu, Yameng; Koo, Jahyun; Choi, Yeon Sik; Xie, Zhaoqian; Chen, Sheena W.; Kandela, Irawati k; Yao, Shenglian; Deng, Yujun; Avila, Raudel; Liu, Tzu Li; Bai, Wubin; Yang, Yiyuan; Han, Mengdi; Zhang, Qihui; Haney, Chad R.; Benjamin Lee, K.; Aras, Kedar; Wang, Tong; Seo, Min Ho; Luan, Haiwen; Lee, Seung Min; Brikha, Anlil; Ghoreishi-Haack, Nayereh; Tran, Lori; Stepien, Iwona; Aird, Fraser; Waters, Emily A.; Yu, Xinge; Banks, Anthony; Trachiotis, Gregory D.; Torkelson, John M.; Huang, Yonggang; Kozorovitskiy, Yevgenia; Efimov, Igor R.; Rogers, John A., Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues, Nature materials (2021).