Faculty Directory

Igor Efimov

Professor of Biomedical Engineering

Professor of Medicine (Division of Cardiology)

Director of Graduate Studies for Biomedical Engineering

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The Efimov Lab

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Research Interests

Igor Efimov’s Research Interests: My Cardiovascular Engineering and Technology laboratory focuses on the physiological mechanisms of cardiovascular disease and on developing novel therapies for heart diseases with an emphasis on heart rhythm disorders and heart failure. Two bioengineering strategies are pursued: (1) development of novel implantable, interventional, and wearable bioelectronic devices for real-time device-based diagnostics and therapy of heart diseases and sudden cardiac death; (2) development of novel approaches to bioinformatics and machine learning to diagnose early stages or predisposition to heart disease and to guide the development of novel therapies. 

Selected Publications

• Quirion, Nathaniel T.; Madrid, Micah; Chang, Jialin; Fehr, Amy; Rytkin, Eric; Shields, Nora; Burke, Bridget; Elekeokwuri, Amarachi; Efimov, Igor R.; Lu, Luyao, A soft multimodal optoelectronic array interface for multiparametric mapping of heart function in vivo, Science Advances (2025).
• Fullenkamp, Dominic E.; Maeng, Woo Youl; Oh, Seyong; Luan, Haiwen; Kim, Kyung Su; Chychula, Ivana A.; Kim, Jin Tae; Yoo, Jae Young; Holgren, Cory W.; Demonbreun, Alexis R.; George, Sharon Ann; Li, Binjie; Hsu, Yaching; Chung, Gooyoon; Yoo, Jeongmin; Koo, Jahyun; Park, Yoonseok; Efimov, Igor Rudolf; McNally, Elizabeth M; Rogers, John A., Simultaneous electromechanical monitoring in engineered heart tissues using a mesoscale framework, Science Advances (2024).
• Das, Devleena; Rytkin, Eric; Das, Jagotamoy; Deng, Jiangdong; Trampel, Katy; Efimov, Igor; Kelley, Shana, Implantable Cardiac Patch Continuously Monitors Acute Heart Failure Biomarkers In Vivo and Ex Vivo, JACC: Basic to Translational Science (2025).
• Zhang, Yamin; Rytkin, Eric; Zeng, Liangsong; Kim, Jong Uk; Tang, Lichao; Zhang, Haohui; Mikhailov, Aleksei; Zhao, Kaiyu; Wang, Yue; Ding, Li; Lu, Xinyue; Lantsova, Anastasia; Aprea, Elena; Jiang, Gengming; Li, Shupeng; Seo, Seung Gi; Wang, Tong; Wang, Jin; Liu, Jiayang; Gu, Jianyu; Liu, Fei; Bailey, Keith; Li, Yat Fung Larry; Burrell, Amy; Pfenniger, Anna; Ardashev, Andrey; Yang, Tianyu; Liu, Naijia; Lv, Zengyao; Purwanto, Nathan S.; Ying, Yue; Lu, Yinsheng; Hoepfner, Claire; Melisova, Altynai; Gong, Jiarui; Jeong, Jinheon; Choi, Junhwan; Hou, Alex; Nolander, Rachel; Bai, Wubin; Jin, Sung Hun; Ma, Zhenqiang; Torkelson, John M.; Huang, Yonggang; Ouyang, Wei; Arora, Rishi K.; Efimov, Igor R.; Rogers, John A., Millimetre-scale bioresorbable optoelectronic systems for electrotherapy, Nature (2025).
• Efimov, Igor R., Light can restore a heart’s rhythm, Nature (2024).
• Deviatiiarov, Ruslan M.; Gams, Anna; Kulakovskiy, Ivan V.; Buyan, Andrey; Meshcheryakov, Georgy; Syunyaev, Roman; Singh, Ramesh; Shah, Palak; Tatarinova, Tatiana V.; Gusev, Oleg; Efimov, Igor R., An atlas of transcribed human cardiac promoters and enhancers reveals an important role of regulatory elements in heart failure, Nature Cardiovascular Research (2023).
• Ausra, Jokubas; Madrid, Micah; Yin, Rose T.; Hanna, Jessica; Arnott, Suzanne; Brennan, Jaclyn A.; Peralta, Roberto; Clausen, David; Bakall, Jakob A.; Efimov, Igor R.; Gutruf, Philipp, Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation, Science Advances (2022).
• Yin, Rose T.; Chen, Sheena W.; Benjamin Lee, K.; Choi, Yeon Sik; Koo, Jahyun; Yang, Quansan; Napolitano, Michael A.; Ausra, Jokubas; Holleran, Timothy J.; Lapiano, Jessica B.; Alex Waters, E.; Brikha, Anlil; Kowalik, Grant; Miniovich, Alana N.; Knight, Helen S.; Russo, Bender A.; Kiss, Alexi; Murillo-Berlioz, Alejandro; Efimova, Tatiana; Haney, Chad R.; Gutruf, Philipp; Rogers, John A.; Trachiotis, Gregory D.; Efimov, Igor R., Open thoracic surgical implantation of cardiac pacemakers in rats, Nature Protocols (2023).