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  • Nov
    8

    ChBE Seminar Series: Laura Segatori

    McCormick-Chemical and Biological Engineering

    9:00 AM L211, Technological Institute

    EVENT DETAILS

    Laura Segatori of Rice University.

    Host: Danielle Tullman-Ercek

    Title:
    Engineering synthetic regulatory systems to reprogram mammalian cells

    Abstract:
    The chemical and energetic properties specified by a protein’s amino acid sequence and encoded by our genome, while determining the protein folding energy landscape, are only part of what shapes how proteins evolve their function. A sophisticated network of macromolecular assistants is needed to control protein synthesis and folding, and mediate degradation of aberrant proteins – functions achieved through completely different and independent mechanisms balanced extrinsically by chemical feedback agents. We seek to develop novel biotechnologies to manipulate these mechanisms for applications ranging from systems-level investigations of protein function to development of therapeutic approaches for restoring cellular homeostasis. We employ synthetic biology tools to develop genetic circuits that interface with pathways that mediate protein folding and degradation (e.g., the Ubiquitin-Proteasome System and the Unfolded Protein Response) with the ultimate goal to monitor and manipulate cellular protein levels with high specificity, sensitivity, and dynamic resolution. We recently developed a technology for degrading a target protein with high specificity and selectivity that provides dynamic control over protein accumulation and that can be customized to target any cellular protein and post-translational modifications (ACS Synth Biol. 2018 Feb 16;7(2):540-552). We have deployed this technology to improve the design of synthetic gene circuits through stimulus-dependent, targeted depletion of the circuit reporter and, ultimately, develop a universal platform for monitoring changes in gene expression with high sensitivity and dynamic resolution. I will discuss the use these tunable cell-based platforms not only to monitor and engineer cellular protein degradation but also to generate novel tool for the mammalian synthetic biology community.

    Biography:
    Laura Segatori is an Assistant Professor of Bioengineering at Rice University with joint appointments in the departments of Chemical & Biomolecular Engineering and Biosciences. She received a Laurea in Industrial Biotechnology from the University of Bologna in Italy in 2000 and a PhD in Chemical Engineering from the University of Texas at Austin in 2005. She completed her postdoctoral work at The Scripps Research Institute in La Jolla California and joined the faculty at Rice University in 2007. She is the recipient of the NSF CAREER Award. Her research group is highly interdisciplinary and combines principles and tools from engineering and science to decipher and manipulate cellular quality control mechanisms that underlie the development of human diseases. Current research interests include the design of synthetic biology tools and nanotechnology-based approaches to engineer protein degradation pathways in the complex environment of mammalian cells.

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    TIME Thursday, November 8, 2018 at 9:00 AM - 10:00 AM

    LOCATION L211, Technological Institute    map it

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    CONTACT Elizabeth Rentfro    elizabeth.rentfro@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering

  • May
    1

    BTP Seminar Series: Jorge Vazquez Anderson, Boston Consulting Group

    McCormick-Chemical and Biological Engineering (ChBE)

    4:30 PM

    EVENT DETAILS

    TIME Wednesday, May 1, 2024 at 4:30 PM - 5:30 PM

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    CONTACT Will Chaussee    william.chaussee@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    2

    ChBE Seminar Series: "Interfacial colloidal interactions, dynamics, and assembly: from biomembranes to ordered 2D materials" - Peter Beltramo, University of Massachusetts

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    TIME Thursday, May 2, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

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    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    8

    Extending Care: A Conversation about Conservation and Futurity

    Block Museum of Art

    6:00 PM Block Museum of Art, Mary and Leigh

    EVENT DETAILSmore info

    TIME Wednesday, May 8, 2024 at 6:00 PM - 7:30 PM

    LOCATION Block Museum of Art, Mary and Leigh    map it

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    CONTACT Block Museum of Art    block-museum@northwestern.edu EMAIL

    CALENDAR Block Museum of Art

  • May
    9

    ChBE Seminar Series: Influence of visible photons on catalytic reactions at metal nanoparticle surfaces - Phillip Christopher, University of California, Santa Barbara

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    TIME Thursday, May 9, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

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    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    16

    35th Annual Hugh M. Hulburt Memorial Lecture: "Adsorption Thermodynamics for Process Simulation" - Chau-Chyun Chen, Texas Tech University

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4 (M113), Technological Institute

    EVENT DETAILS

    TIME Thursday, May 16, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4 (M113), Technological Institute    map it

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    CONTACT Jennifer Young    jennifer.young@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    23

    ChBE Seminar Series: ARDEI Annual Lecture - "Restructuring the STEM Pipeline: Dismantling Stereotypes and Microaggressions in STEM to Build Networks of Belonging and Support" - Christine Reyna, DePaul University

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    TIME Thursday, May 23, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

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    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    30

    ChBE Seminar Series: Ruihan Li and Kunhuan Liu, Student Seminars

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    TIME Thursday, May 30, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

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    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • Jun
    10

    Northwestern Engineering PhD Hooding and Master's Degree Recognition Ceremony

    McCormick School of Engineering and Applied Science

    9:00 AM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 9:00 AM - 11:00 AM

    LOCATION Welsh-Ryan Arena   

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    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Jun
    10

    Northwestern Engineering Undergraduate Convocation

    McCormick School of Engineering and Applied Science

    2:00 PM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 2:00 PM - 4:00 PM

    LOCATION Welsh-Ryan Arena   

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    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Aug
    14

    Undergraduate Quantum Summer School

    McCormick School of Engineering and Applied Science

    All Day Ford Motor Company Engineering Design Center

    EVENT DETAILSmore info

    TIME Wednesday, August 14, 2024

    LOCATION Ford Motor Company Engineering Design Center    map it

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    CONTACT Dongyang Li    lidongyang@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science