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  • Dec
    7

    IEMS Seminar: Multiple Testing in Clinical Trials

    Department of Industrial Engineering and Management Sciences

    11:00 AM Hive 2.350, Ford Motor Company Engineering Design Center

    EVENT DETAILS

    Ajit Tamhane, Ph.D.

    Multiple Testing in Clinical Trials

    Abstract: In this talk I will give an overview of some multiple testing problems in clinical trials that I have worked on in recent years. These problems came to me through some consulting work and have led to interesting theoretical developments resulting in publications in the top journals in the field (listed below in the references).

    First I will review some basic concepts in multiple testing such as familywise error rate control, closed testing, group sequential designs and graphical methods. Then I will apply these concepts to the general problem of hierarchical (gatekeeping) testing of primary and secondary endpoints in a group sequential clinical trial. I will consider in some detail three special cases of this general problem.

    The focus of the talk will be the ideas behind the results and not the technical proofs. As such, this talk should be accessible to all.

    References:

    1. Tamhane, A. C., Mehta, C. R. and Liu, L. (2010), “Testing a primary and a secondary endpoint in a group sequential design,” Biometrics, 66, 1174-1184.

    2. Tamhane, A. C., Wu, Y. and Mehta, C. R. (2012), “Adaptive extensions of a two-stage group sequential procedure for testing a primary and a secondary endpoint (I): Unknown correlation between the endpoints,” Statistics in Medicine, 31, 2027-2040.

    3. Tamhane, A. C., Gou, J., Jennison, C. Mehta, C. R. and Curto, T. (2018), ``A gatekeeping procedure for testing a primary and a secondary endpoint in a group sequential design with multiple interim looks,'' Biometrics, 74. 40-48.

    Bio:

    Ajit Tamhane is Professor of Industrial Engineering & Management Sciences (IEMS) with a courtesy appointment in Statistics at Northwestern University.

    He has published over 100 papers in peer-reviewed journals in the areas of multiple testing, design of experiments, ranking and selection procedures, chemometrics and other related areas. He has authored or coauthored four books and co-edited two volumes of research papers..

    He is an elected fellow of the American Statistical Association (1991), the Institute of Mathematical Statistics (2010), the American Association for Advancement of Science (2013) and an elected member of the International Statistical Institute (2015).

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    TIME Tuesday, December 7, 2021 at 11:00 AM - 12:00 PM

    LOCATION Hive 2.350, Ford Motor Company Engineering Design Center    map it

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    CONTACT Agnes Kaminski    a-kaminski@northwestern.edu EMAIL

    CALENDAR Department of Industrial Engineering and Management Sciences

  • Apr
    30

    Learning and Information Aggregation in Dynamic Games

    Department of Industrial Engineering and Management Sciences (IEMS)

    11:00 AM ITW 1.350, Ford Motor Company Engineering Design Center

    EVENT DETAILS

    TIME Tuesday, April 30, 2024 at 11:00 AM - 12:00 PM

    LOCATION ITW 1.350, Ford Motor Company Engineering Design Center    map it

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    CONTACT Kendall Minta    kendall.minta@gmail.com EMAIL

    CALENDAR Department of Industrial Engineering and Management Sciences (IEMS)

  • May
    8

    Extending Care: A Conversation about Conservation and Futurity

    Block Museum of Art

    6:00 PM Block Museum of Art, Mary and Leigh

    EVENT DETAILSmore info

    TIME Wednesday, May 8, 2024 at 6:00 PM - 7:30 PM

    LOCATION Block Museum of Art, Mary and Leigh    map it

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    CONTACT Block Museum of Art    block-museum@northwestern.edu EMAIL

    CALENDAR Block Museum of Art

  • May
    17

    MLDS Exchange 2024

    Master of Science in Machine Learning and Data Science (MLDS)

    9:00 AM 633 N St Clair Street

    EVENT DETAILS

    TIME Friday, May 17, 2024 at 9:00 AM - 5:00 PM

    LOCATION 633 N St Clair Street   

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    CONTACT Master of Science in Machine Learning and Data Science Program    mlds@northwestern.edu EMAIL

    CALENDAR Master of Science in Machine Learning and Data Science (MLDS)

  • Jun
    10

    Northwestern Engineering PhD Hooding and Master's Degree Recognition Ceremony

    McCormick School of Engineering and Applied Science

    9:00 AM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 9:00 AM - 11:00 AM

    LOCATION Welsh-Ryan Arena   

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    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Jun
    10

    Northwestern Engineering Undergraduate Convocation

    McCormick School of Engineering and Applied Science

    2:00 PM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 2:00 PM - 4:00 PM

    LOCATION Welsh-Ryan Arena   

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    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Aug
    14

    Undergraduate Quantum Summer School

    McCormick School of Engineering and Applied Science

    All Day Ford Motor Company Engineering Design Center

    EVENT DETAILSmore info

    TIME Wednesday, August 14, 2024

    LOCATION Ford Motor Company Engineering Design Center    map it

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    CONTACT Dongyang Li    lidongyang@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Aug
    15

    Undergraduate Quantum Summer School

    McCormick School of Engineering and Applied Science

    All Day Ford Motor Company Engineering Design Center

    EVENT DETAILSmore info

    TIME Thursday, August 15, 2024

    LOCATION Ford Motor Company Engineering Design Center    map it

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    CONTACT Dongyang Li    lidongyang@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science