Faculty Directory
Evan Scott

Kay Davis Professor

Associate Professor of Biomedical Engineering

Director of PhD Admissions of Biomedical Engineering

Contact

2145 Sheridan Road
Silverman Hall 4613
Evanston, IL 60208

847-467-6719Email Evan Scott

Website

Evan Scott Research Group


Departments

Biomedical Engineering

Affiliations

PhD Program in Interdisciplinary Biological Sciences


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Education

Ph.D., Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO

Sc.B. with Honors, Biomedical Engineering, Brown University, Providence, RI


Research Interests

The overall research objective of my laboratory is to investigate the basic inflammatory and immunological processes contributing to diverse pathologies and develop targeted therapeutic approaches using engineering- and materials-based strategies. More specifically, we aim to achieve controlled elicitation or suppression of the immune system via the rational design of delivery systems that target key inflammatory cell populations. We approach this by synthesizing, assembling and testing in vivo a range of nanostructures loaded with strategically selected combinations of immunostimulants. By validating our immunostimulatory nanomaterials in mouse models for heart disease, cancer, and Chagas disease, we intend to demonstrate therapeutic immunomodulation based on the rational design of synthetic materials.  


Selected Publications

    1. Stack T, Vincent T, Vahabikashi A, Li G, Perkumas KM, Stamer WD, Johnson M, Scott EA. Targeted Delivery of Cell Softening Micelles to Schlemm’s Canal Endothelial Cells for Treatment of Glaucoma. Small. 2020. DOI:10.1002/smll.202004205

    2. Du F, Qiao B, Nguyen TD, Vincent M, Bobbala S, Yi S, Lescott C, Dravid VP, Olvera de la Cruz O, Scott EA. Homopolymer self-assembly of poly(propylene sulfone) hydrogels via dynamic noncovalent sulfone-sulfone bonding. Nat. Commun. 2020. DOI: 10.1038/s41467-020-18657-5

    3. Frey M, Vincent M, Bobbala S, Burt R, Scott EA. Mapping the supramolecular assembly space of poly(sarcosine)-b-poly(propylene sulfide) using a combinatorial copolymer library. ChemComm. 2020. DOI: 10.1039/D0CC00925C.

    4. Bobbala S, Allen SD, Yi S, Vincent M, Frey M, Karabin N, Scott EA. Employing Bicontinuous-to-Micellar Transitions in Nanostructure Morphology for On-Demand Photo-Oxidation Responsive Cytosolic Delivery and off-on Cytotoxicity. Nanoscale. 2020. DOI: 10.1039/C9NR10921H.

    5. Yi S, Zhang X, Sangji H, Liu L, Allen S, Xiao B, Bobbala S, Braverman C, Cai L, Hecker P, DeBerge M, Thorp E, Temel R, Stupp S, Scott EA. Surface engineered polymersomes for enhanced modulation of dendritic cells during cardiovascular immunotherapy. Adv. Funct. Mat. 2019. DOI: 10.1002/adfm. 201904399.

    6. Shang S, Kats D, Cao L, Morgun E, Velluto D, He Y, Xu Q, Wang C-R, Scott EA. Induction of Mycobacterium Tuberculosis Lipid-Specific T Cell Responses by Pulmonary Delivery of Mycolic Acid-Loaded Polymeric Micellar Nanocarriers. Front. Immunol. 2018. 9(2709).DOI: 10.1021/acsami.8b09906.

    7. Allen SD, Liu YG, Bobbala S, Cai L, Hecker PI, Temel R, Scott EA. Polymersomes scalably fabricated via flash nanoprecipitation are non-toxic in non-human primates and associate with leukocytes in the spleen and kidney following intravenous administration. Nano Res. 2018. DOI:10.1007/s12274-018-2069-x.

    P8. Karabin NB, Allen S, Kwon H, Firlar E, Wang Q, Shokuhfar T, Shull K, Scott EA. Sustained Micellar Delivery via Inducible Transitions in Nanostructure Morphology. Nat. Commun. 2018. DOI:10.1038/s41467-018-03001-9.

    P9. Allen S, Osorio O, Liu YG, Scott EA. Facile assembly and loading of theranostic polymersomes via multi-impingement flash nanoprecipitation. J. Control. Release. 2017; 262:91-103. DOI: 10.1016/j.jconrel.2017.07.026.

    P10. Du F, Liu YG, Scott EA. Immunotheranostic Polymersomes Modularly Assembled from Tetrablock and Diblock Copolymers with Oxidation-Responsive Fluorescence. Cell. Mol. Bioeng. (2017). DOI: 10.1007/s12195-017-0486-7.

    P11. Dowling DJ†‡, Scott EA†‡, Scheid A, Bergelson I, Joshi S, Pietrasanta C, Brightman S, Sanchez-Schmitz G, Van Haren SD, Ninković J, Kats D, Guiducci C, de Titta A, Bonner DK, Hirosue S, Swartz MA, Hubbell‡, JA, Levy O‡. Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses, J. Allergy Clin. Immunol. 2017 Mar 14. pii: S0091-6749(17)30242-7. DOI: 10.1016/j.jaci.2016.12.985. 

    P12. Scott EA, Karabin NB, Augsornworawat P. Overcoming immune dysregulation with immunoengineered nanobiomaterials. Annu. Rev. Biomed. Eng. 2017 19:1. DOI: 10.1146/annurev-bioeng-071516-044603

Patents

Elbert DL, Scott EA, Nichols MD. “Hydrogel Microparticle Formation in Aqueous Solvent for Biomedical Applications”, US provisional patent application 61/089310 (2008).

Elbert DL, Scott EA, Kaneda M , Wacker BK, Alford SK. “Biomaterials Having Nanoscale Layers and Coatings”, International Application Number PCT/US2007/063142 filed Mar. 2, 2007.