Faculty Directory
Evan Scott

Assistant Professor of Biomedical Engineering

Contact

2145 Sheridan Road
Silverman Hall 4613
Evanston, IL 60208

847-467-6719Email Evan Scott

Website

Evan Scott Research Group


Departments

Biomedical Engineering

Affiliations

PhD Program in Interdisciplinary Biological Sciences


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Education

Ph.D., Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO

Sc.B. with Honors, Biomedical Engineering, Brown University, Providence, RI


Research Interests

The overall research objective of my laboratory is to investigate the basic inflammatory and immunological processes contributing to diverse pathologies and develop targeted therapeutic approaches using engineering- and materials-based strategies. More specifically, we aim to achieve controlled elicitation or suppression of the immune system via the rational design of delivery systems that target key inflammatory cell populations. We approach this by synthesizing, assembling and testing in vivo a range of nanostructures loaded with strategically selected combinations of immunostimulants.  By validating our immunostimulatory nanomaterials in mouse models for heart disease, cancer, and Chagas disease, we intend to demonstrate therapeutic immunomodulation based on the rational design of synthetic materials.  


Selected Publications

    Link to Google Scholar Profile

    P.36  Allen SD, Bobbala S, Karabin NB, Scott EA. On the advancement of polymeric bicontinuous nanospheres toward biomedical applications. Nanoscale Horizons. 2019. DOI: 10.1039/C8NH00300A.

    P.35  Shang S, Kats D, Cao L, Morgun E, Velluto D, He Y, Xu Q, Wang C-R, Scott EA. Induction of Mycobacterium Tuberculosis Lipid-Specific T Cell Responses by Pulmonary Delivery of Mycolic Acid-Loaded Polymeric Micellar Nanocarriers. Front. Immunol. 2018. 9(2709).DOI: 10.1021/acsami.8b09906.

    P.34  Allen S, Bobbala S, Karabin NB, Modak M, Scott EA.  Benchmarking bicontinuous nanospheres against polymersomes for in vivo biodistribution and dual intracellular delivery of lipophilic and water soluble payloads. ACS Appl. Mater. Interfaces. 2018 Sept 14. DOI: 10.1021/acsami.8b09906.

    P.33  Frey M, Bobbala S, Karabin N, Allen S, Scott EA. Influences of nanocarrier morphology on immunotherapy. Nanomedicine. 2018 Aug 7. DOI: 10.2217/nnm-2018-0052.

    P.32  Allen S, Vincent M, Scott EA.  Rapid, scalable assembly and loading of bioactive proteins and immunostimulants into diverse synthetic nanocarriers via flash nanoprecipitation.  JoVE. (138), 2018. e57793, DOI:10.3791/57793.

    P.31  Firlar E, Karabin N, Bogdanowicz A, Nadkarni Y, Scott E, Shahbazian-Yassar R, Shokuhfar T. Investigation of In Situ Radiation Effects in Liquid Cell Electron Microscopy. Microscopy and Microanalysis. 2018 24(S1), 1980-1981. doi:10.1017/S1431927618010383

    P.30 Roy I, Bobbala S, Zhou J, Nguyen MT, Nalluri SKM, Wu Y, Ferris D, Scott EA, Wasielewski MR, Stoddart JF. ExTzBox: A Glowing Cyclophane for Live-Cell Imaging. JACS. 2018. DOI: 10.1021/jacs.8b03066.

    P.29  Allen SD, Liu YG, Bobbala S, Cai L, Hecker PI, Temel R, Scott EA. Polymersomes scalably fabricated via flash nanoprecipitation are non-toxic in non-human primates and associate with leukocytes in the spleen and kidney following intravenous administration. Nano Res. 2018. DOI:10.1007/s12274-018-2069-x.

    P.28  Du F, Bala S, Yi S, Scott EA. Sequential Intracellular Release of Water-Soluble Cargos from Shell-Crosslinked Polymersomes. J. Control. Release. 2018. DOI:10.1016/j.jconrel.2018.03.027.

    P.27  Stack T, Vahabikashi A, Johnson M, Scott EA. Modulation of Schlemm’s Canal endothelial cell stiffness via latrunculin loaded block copolymer micelles. J. Biomed. Mater. Res. A. 2018. DOI: 10.1002/jbm.a.36376.

    P.26  Karabin NB, Allen S, Kwon H, Firlar E, Wang Q, Shokuhfar T, Shull K, Scott EA. Sustained Micellar Delivery via Inducible Transitions in Nanostructure Morphology. Nat. Commun. 2018. DOI:10.1038/s41467-018-03001-9.

    P.25  Bobbala S, Allen SD, Scott EA. Flash nanoprecipitation permits versatile assembly and loading of polymeric bicontinuous cubic nanospheres. Nanoscale. 2018. DOI: 10.1039/c7nr06779h.

    P.24  Allen S, Osorio O, Liu YG, Scott EA. Facile assembly and loading of theranostic polymersomes via multi-impingement flash nanoprecipitation. J. Control. Release. 2017; 262:91-103. DOI: 10.1016/j.jconrel.2017.07.026.

    P.23  Du F, Liu YG, Scott EA. Immunotheranostic Polymersomes Modularly Assembled from Tetrablock and Diblock Copolymers with Oxidation-Responsive Fluorescence. Cell. Mol. Bioeng. (2017). DOI: 10.1007/s12195-017-0486-7.

    This article is part of the 2017 Young Innovators Issue.

    P.22  Scott EA, Karabin NB, Augsornworawat P. Overcoming immune dysregulation with immunoengineered nanobiomaterials. Annu. Rev. Biomed. Eng. 2017 19:1. DOI: 10.1146/annurev-bioeng-071516-044603

    P.21  Dowling DJ†‡, Scott EA†‡, Scheid A, Bergelson I, Joshi S, Pietrasanta C, Brightman S, Sanchez-Schmitz G, Van Haren SD, Ninković J, Kats D, Guiducci C, de Titta A, Bonner DK, Hirosue S, Swartz MA, Hubbell‡, JA, Levy O‡. Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses, J. Allergy Clin. Immunol. 2017 Mar 14. pii: S0091-6749(17)30242-7. DOI: 10.1016/j.jaci.2016.12.985.

    †Contributed equally to this work.  ‡Corresponding authors.

    This article was highlighted by the National Institute of Allergy and Infectious Diseases (NIAID): https://www.niaid.nih.gov/news-events/new-adjuvant-permits-early-pneumococcal-immunization-newborn-monkeys

    P.20  Zhang S, DeBerge M, Yeap XY, Naresh NK, Wang K, Jiang Z, Wilcox JE, White SM, Morrow JP, Burridge PW, Procissi D, Scott EA, Frazier W, Thorp EB. Acute CD47 blockade during ischemic myocardial reperfusion enhances phagocytosis-associated cardiac repair. JACC: Basic Transl. Sci. 2017, 2 (4) 386-397; DOI: 10.1016/j.jacbts.2017.03.013.

    P.19  Yi S, Liu Y, Allen S, Liu YG, Li X, Ouyang B, Augsornworawat P, Thorp EB, Scott EA. Tailoring Nanostructure Morphology for Enhanced Targeting of Dendritic Cells in Atherosclerosis. ACS Nano. 2016;10(12):11290-303. DOI: 10.1021/acsnano.6b06451.

    P.18  Allen S, Liu YG, Scott EA. Engineering nanomaterials to address cell-mediated inflammation in atherosclerosis. Regen. Engin. Trans. Med. 2016 March 03; 1-14. DOI: 10.1007/s40883-016-0012-9.

    P.17  Vasdekis AE, Scott EA, S. Roke, Hubbell JA, Psaltis D. Vesicle photonics, Annu. Rev. Mater. Res. 2013;43: 283-305.

    P.16  Stano A, Scott EA, Dane K, Swartz MA, Hubbell JA. Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles, Biomaterials. 2013 Jun;34(17):4339-46.

    P.15  Vasdekis AE†, Scott EA†, Psaltis D, Hubbell JA. Precision cytosolic delivery based on optofluidic polymersome rupture, ACS Nano. 2012 Sep 25;6(9):7850-7.

             †Contributed equally to this work.

    P.14  Scott EA, Stano A, Gillard M, Maio-Liu AC, Swartz MA, Hubbell JA. Dendritic cell activation and T cell priming with adjuvant and antigen-loaded oxidation-sensitive polymersomes, Biomaterials.2012 Sep;33(26):6211-9.

    P.13  Ovod V, Scott EA, Flake MM, Parker SR, Bateman RJ, Elbert DL. Exposure of the lysine in the gamma chain dodecapeptide of human fibrinogen is not enhanced by adsorption to poly(ethylene terephthalate) as measured by biotinylation and mass spectrometry, J. Biomed. Mater. Res. A, 2012 Mar;100(3):622-31.

    P.12  Scott EA, Nichols MD, Willits RK, Elbert DL. Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen. Acta Biomater. 2010 Jan;6(1):29-38. 

    P.11  Nichols MD, Scott EA, Elbert DL.  Factors affecting size and swelling of poly(ethylene glycol) microspheres formed in aqueous sodium sulfate solutions without surfactants. Biomaterials. 2009 Oct;30(29):5283-91.

    P.10   Chang SH, Custer PL,Mohadjer Y, Scott E. Use of Lorenz® titanium implants in orbital fracture repair. Ophthal. Plast. Reconstr. Surg. 2009 Mar-Apr;25(2):119-22.

    P.9    Scott EA, Nichols MD, Cordova LH, George BJ, Jun YS, Elbert DL. Protein adsorption and cell adhesion on nanoscale bioactive coatings formed from poly(ethylene glycol) and albumin microgels. Biomaterials. 2008 Dec;29(34):4481-93.

    P.8     Elbert DL, Mawuenyega K, Scott EA, Bateman RJ. Stable isotope labeling tandem mass spectrometry (SILT): Integration with peptide identification and extension to data-dependent scans. J. Proteome Res. 2008 Sep 6;7 (10), pp 4546–4556.

    P.7    Wacker BK, Alford SK, Scott EA, Das Thakur M, Longmore GD, Elbert DL. Endothelial cell migration on RGD-peptide containing PEG hydrogels in the presence of sphingosine 1-phosphate. Biophys J. 2008 Jan 1;94(1):273-85.

    P.6    Scott EA, Elbert DL. Mass spectrometric mapping of fibrinogen conformations at poly(ethylene terephthalate) interfaces. Biomaterials. 2007 Sep;28(27):3904-17.

    P.5    Wacker BK, Scott EA, Hughes SK, Elbert DL. Delivery of sphingosine 1-phosphate from poly(ethylene glycol) hydrogels. Biomacromolecules. 2006 Apr; 7(4):1335-1343.

    P.4    Kim JK, Scott EA, Elbert DL. Proteomic analysis of protein adsorption: Serum amyloid P adsorbs to materials and promotes leukocyte adhesion. J. Biomed. Mater. Res. A 2005 Oct 1;75(1):199-209.

    P.3    Godbee J, Cheifetz PM, Scott EA, Bubbers EJ, Mathiowitz E. In vitro and in vivo analysis of antide delivery from multi-phase microspheres fabricated via solvent removal. Isr J. Chem. 2005 Sep;45(4):445-456.

    P.2    Godbee J, Pattamunuch P, Scott E, Mathiowitz E. Degradation of multi-phase microspheres fabricated via solvent removal. J. Microencapsul. 21(3) 2004: 331-352.

    P.1     Godbee J, Scott E, Pattamunuch P, Chen S, Mathiowitz E. Role of solvent/non-solvent ratio on microsphere formation using the solvent removal method. J. Microencapsul. 21(2) 2004:151-160.

Patents

Elbert DL, Scott EA, Nichols MD. “Hydrogel Microparticle Formation in Aqueous Solvent for Biomedical Applications”, US provisional patent application 61/089310 (2008).

Elbert DL, Scott EA, Kaneda M , Wacker BK, Alford SK. “Biomaterials Having Nanoscale Layers and Coatings”, International Application Number PCT/US2007/063142 filed Mar. 2, 2007.