News & Events
Department Events

Events

  • Mar
    4

    TAM Seminar: Prof. Wendy C. Crone

    McCormick - Civil and Environmental Engineering

    10:00 AM

    EVENT DETAILSmore info

    TAM Seminar Series Presents:

    Wendy C. Crone
    Karen Thompson Medhi Professor of the College of Engineering
    Discovery Fellow in the Wisconsin Institute for Discovery
    University of Wisconsin-Madison

    An Engineered Culture System for Human Cardiac Syncytium: Structural, Mechanical, and Electrical Readouts of Heart Cells in a Dish

    Thursday, March 4th • 10:00AM CST

    Please log on with your Northwestern account (https://northwestern.zoom.us) to join.

    Abstract

    Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) have emerged as an exciting new tool for cardiac research and can serve as a pre-clinical platform for drug development and disease modeling studies. However, these aspirations are limited by current culture methods in which hPSC-CMs resemble fetal human cardiomyocytes in terms of structure and function. The Crone Lab has produced a novel platform for use with hPSC-CMs and human pluripotent stem cell-derived cardiac fibroblasts (hPSC-CFs), that includes patterned extracellular matrix (ECM) with physiological substrate stiffness to enhance these cells for in vitro studies. The platform is amenable to structural, mechanical, and electrical characterization.

    When iPSC-CFs are confined to the micropatterned features of the platform they remodel the ECM into anisotropic fibers. Micropatterned lanes promote the cellular and myofibril alignment of hPSC-CMs while the addition of micropatterned bridges enable formation of a functional cardiac syncytium that beats synchronously over a large 2D area within the platform. Investigation of electrophysiological properties of the patterned cardiac constructs with optical mapping shows that they have anisotropic electrical impulse propagation, as occurs in the native myocardium. Interrogation of the mechanical function of the pattern constructs using digital image correlation (DIC) demonstrates the utility of this platform for mechanical characterization of coordinated contractions. Our results also show that iPSC-CFs influence iPSC-CM function with accelerated Ca2+ transient rise-up time and greater contractile strains in the co-culture conditions compared to when iPSC-CMs are cultured alone. Preliminary results will also be presented on the utility of this platform to investigate a hypertrophic cardiomyopathy (HCM) disease model.

    Biography

    Wendy C. Crone is the Karen Thompson Medhi Professor in the Department of Engineering Physics at the University of Wisconsin–Madison and is a Discovery Fellow with the Wisconsin Institute for Discovery. Her research is in the area of solid mechanics and is connected with biotechnology and nanotechnology. She has applied her technical expertise to improving fundamental understanding of mechanical response of materials, enhancing material behavior through surface modification and nanostructuring, exploring the interplay between cells and the mechanics of their surroundings, and developing new material applications and medical devices. Prof. Crone is a Fellow of the Society for Experimental Mechanics and has served in several leadership roles at UW-Madison, including prior appointments as Interim Dean and Associate Dean of the Graduate School.

    more less

    TIME Thursday, March 4, 2021 at 10:00 AM - 11:00 AM

    ADD TO CALENDAR

    CONTACT Alison Rodriguez    alison.rodriguez@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering

  • Apr
    26

    EES Seminar Series- Kaize Ding

    McCormick - Civil and Environmental Engineering (CEE)

    2:00 PM A236, Technological Institute

    EVENT DETAILS

    TIME Friday, April 26, 2024 at 2:00 PM - 3:00 PM

    LOCATION A236, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Andrew Liguori    andrew.liguori@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering (CEE)

  • May
    1

    SPREE Seminar Series- Roman Makhenko

    McCormick - Civil and Environmental Engineering (CEE)

    11:00 AM A236, Technological Institute

    EVENT DETAILS

    TIME Wednesday, May 1, 2024 at 11:00 AM - 12:00 PM

    LOCATION A236, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Andrew Liguori    andrew.liguori@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering (CEE)

  • May
    3

    EES Seminar Series- X-ray fluorescence microscopy for life and environmental studies at the Advanced Photon Source- Si Chen

    McCormick - Civil and Environmental Engineering (CEE)

    2:00 PM A236, Technological Institute

    EVENT DETAILS

    TIME Friday, May 3, 2024 at 2:00 PM - 3:00 PM

    LOCATION A236, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Andrew Liguori    andrew.liguori@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering (CEE)

  • May
    6

    AED/MPM PD Seminar Series- Steve Nargang

    McCormick - Civil and Environmental Engineering (CEE)

    11:00 AM 1101, Pancoe-NSUHS Life Sciences Pavilion

    EVENT DETAILS

    TIME Monday, May 6, 2024 at 11:00 AM - 12:00 PM

    LOCATION 1101, Pancoe-NSUHS Life Sciences Pavilion    map it

    ADD TO CALENDAR

    CONTACT Andrew Liguori    andrew.liguori@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering (CEE)

  • May
    8

    SPREE Seminar Series- Investigating Single & Multi-Component Polymer Grafted Nanoparticles using Molecular Modelling- Subhadeep Pal

    McCormick - Civil and Environmental Engineering (CEE)

    11:00 AM A236, Technological Institute

    EVENT DETAILS

    TIME Wednesday, May 8, 2024 at 11:00 AM - 12:00 PM

    LOCATION A236, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Andrew Liguori    andrew.liguori@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering (CEE)

  • May
    8

    Extending Care: A Conversation about Conservation and Futurity

    Block Museum of Art

    6:00 PM Block Museum of Art, Mary and Leigh

    EVENT DETAILSmore info

    TIME Wednesday, May 8, 2024 at 6:00 PM - 7:30 PM

    LOCATION Block Museum of Art, Mary and Leigh    map it

    ADD TO CALENDAR

    CONTACT Block Museum of Art    block-museum@northwestern.edu EMAIL

    CALENDAR Block Museum of Art

  • May
    10

    EES Seminar Series- Phosphorous Recycling- Jade Basinski

    McCormick - Civil and Environmental Engineering (CEE)

    2:00 PM A236, Technological Institute

    EVENT DETAILS

    TIME Friday, May 10, 2024 at 2:00 PM - 3:00 PM

    LOCATION A236, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Andrew Liguori    andrew.liguori@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering (CEE)

  • May
    13

    AED/MPM PD Seminar Series- Albert Mena & Maya Stuhlbarg

    McCormick - Civil and Environmental Engineering (CEE)

    11:00 AM 1101, Pancoe-NSUHS Life Sciences Pavilion

    EVENT DETAILS

    TIME Monday, May 13, 2024 at 11:00 AM - 12:00 PM

    LOCATION 1101, Pancoe-NSUHS Life Sciences Pavilion    map it

    ADD TO CALENDAR

    CONTACT Andrew Liguori    andrew.liguori@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering (CEE)

  • May
    15

    SPREE Seminar Series- Understanding Heat Transport at Grain Boundaries Through High Resolution Imaging- Elenora Isotta

    McCormick - Civil and Environmental Engineering (CEE)

    11:00 AM A236, Technological Institute

    EVENT DETAILS

    TIME Wednesday, May 15, 2024 at 11:00 AM - 12:00 PM

    LOCATION A236, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Andrew Liguori    andrew.liguori@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering (CEE)

  • May
    17

    EES Seminar Series- Dave Lampert

    McCormick - Civil and Environmental Engineering (CEE)

    2:00 PM A236, Technological Institute

    EVENT DETAILS

    TIME Friday, May 17, 2024 at 2:00 PM - 3:00 PM

    LOCATION A236, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Andrew Liguori    andrew.liguori@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering (CEE)

  • May
    20

    AED/MPM PD Seminar Series- Andres Marulanda Escobar

    McCormick - Civil and Environmental Engineering (CEE)

    11:00 AM 1101, Pancoe-NSUHS Life Sciences Pavilion

    EVENT DETAILS

    TIME Monday, May 20, 2024 at 11:00 AM - 12:00 PM

    LOCATION 1101, Pancoe-NSUHS Life Sciences Pavilion    map it

    ADD TO CALENDAR

    CONTACT Andrew Liguori    andrew.liguori@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering (CEE)

  • May
    22

    SPREE Seminar Series- Mechanism-Based Multi-Scale Models for Damage and Failure in Heterogeneous Materials- Kedar Kirane

    McCormick - Civil and Environmental Engineering (CEE)

    11:00 AM A236, Technological Institute

    EVENT DETAILS

    TIME Wednesday, May 22, 2024 at 11:00 AM - 12:00 PM

    LOCATION A236, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Andrew Liguori    andrew.liguori@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering (CEE)

  • May
    24

    EES Seminar Series- PFAS Characterization- Gordon Getzinger

    McCormick - Civil and Environmental Engineering (CEE)

    2:00 PM A236, Technological Institute

    EVENT DETAILS

    TIME Friday, May 24, 2024 at 2:00 PM - 3:00 PM

    LOCATION A236, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Andrew Liguori    andrew.liguori@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering (CEE)

  • Jun
    6

    CEE Department Graduation Recognition and Ceremony

    McCormick - Civil and Environmental Engineering (CEE)

    4:00 PM 1702 Chicago Ave

    EVENT DETAILS

    TIME Thursday, June 6, 2024 at 4:00 PM - 8:00 PM

    LOCATION 1702 Chicago Ave   

    ADD TO CALENDAR

    CONTACT Andrew Liguori    andrew.liguori@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering (CEE)

  • Jun
    7

    CEE Graduating Undergraduate Celebrating

    McCormick - Civil and Environmental Engineering (CEE)

    6:00 PM 623 W Howard St

    EVENT DETAILS

    TIME Friday, June 7, 2024 at 6:00 PM - 9:00 PM

    LOCATION 623 W Howard St   

    ADD TO CALENDAR

    CONTACT Andrew Liguori    andrew.liguori@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering (CEE)

  • Jun
    10

    Northwestern Engineering PhD Hooding and Master's Degree Recognition Ceremony

    McCormick School of Engineering and Applied Science

    9:00 AM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 9:00 AM - 11:00 AM

    LOCATION Welsh-Ryan Arena   

    ADD TO CALENDAR

    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Jun
    10

    Northwestern Engineering Undergraduate Convocation

    McCormick School of Engineering and Applied Science

    2:00 PM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 2:00 PM - 4:00 PM

    LOCATION Welsh-Ryan Arena   

    ADD TO CALENDAR

    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science