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  • Mar
    4

    TAM Seminar: Prof. Wendy C. Crone

    McCormick - Civil and Environmental Engineering

    10:00 AM

    EVENT DETAILSmore info

    TAM Seminar Series Presents:

    Wendy C. Crone
    Karen Thompson Medhi Professor of the College of Engineering
    Discovery Fellow in the Wisconsin Institute for Discovery
    University of Wisconsin-Madison

    An Engineered Culture System for Human Cardiac Syncytium: Structural, Mechanical, and Electrical Readouts of Heart Cells in a Dish

    Thursday, March 4th • 10:00AM CST

    Please log on with your Northwestern account (https://northwestern.zoom.us) to join.

    Abstract

    Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) have emerged as an exciting new tool for cardiac research and can serve as a pre-clinical platform for drug development and disease modeling studies. However, these aspirations are limited by current culture methods in which hPSC-CMs resemble fetal human cardiomyocytes in terms of structure and function. The Crone Lab has produced a novel platform for use with hPSC-CMs and human pluripotent stem cell-derived cardiac fibroblasts (hPSC-CFs), that includes patterned extracellular matrix (ECM) with physiological substrate stiffness to enhance these cells for in vitro studies. The platform is amenable to structural, mechanical, and electrical characterization.

    When iPSC-CFs are confined to the micropatterned features of the platform they remodel the ECM into anisotropic fibers. Micropatterned lanes promote the cellular and myofibril alignment of hPSC-CMs while the addition of micropatterned bridges enable formation of a functional cardiac syncytium that beats synchronously over a large 2D area within the platform. Investigation of electrophysiological properties of the patterned cardiac constructs with optical mapping shows that they have anisotropic electrical impulse propagation, as occurs in the native myocardium. Interrogation of the mechanical function of the pattern constructs using digital image correlation (DIC) demonstrates the utility of this platform for mechanical characterization of coordinated contractions. Our results also show that iPSC-CFs influence iPSC-CM function with accelerated Ca2+ transient rise-up time and greater contractile strains in the co-culture conditions compared to when iPSC-CMs are cultured alone. Preliminary results will also be presented on the utility of this platform to investigate a hypertrophic cardiomyopathy (HCM) disease model.

    Biography

    Wendy C. Crone is the Karen Thompson Medhi Professor in the Department of Engineering Physics at the University of Wisconsin–Madison and is a Discovery Fellow with the Wisconsin Institute for Discovery. Her research is in the area of solid mechanics and is connected with biotechnology and nanotechnology. She has applied her technical expertise to improving fundamental understanding of mechanical response of materials, enhancing material behavior through surface modification and nanostructuring, exploring the interplay between cells and the mechanics of their surroundings, and developing new material applications and medical devices. Prof. Crone is a Fellow of the Society for Experimental Mechanics and has served in several leadership roles at UW-Madison, including prior appointments as Interim Dean and Associate Dean of the Graduate School.

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    TIME Thursday, March 4, 2021 at 10:00 AM - 11:00 AM

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    CONTACT Alison Rodriguez    alison.rodriguez@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering

  • Mar
    10

    SPREE Seminar: John van de Lindt

    McCormick - Civil and Environmental Engineering

    11:00 AM

    EVENT DETAILS

    TIME Wednesday, March 10, 2021 at 11:00 AM - 12:00 PM

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    CONTACT Tierney Acott    tierney.acott@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering

  • Mar
    11

    Electronically Integrated Microscopic Robots

    McCormick - Civil and Environmental Engineering

    10:00 AM

    EVENT DETAILSmore info

    TIME Thursday, March 11, 2021 at 10:00 AM - 11:00 AM

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    CONTACT Alison Rodriguez    alison.rodriguez@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering

  • Mar
    12

    EES Seminar: Noah Fierer

    McCormick - Civil and Environmental Engineering

    2:00 PM

    EVENT DETAILS

    TIME Friday, March 12, 2021 at 2:00 PM - 3:00 PM

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    CONTACT Tierney Acott    tierney.acott@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering

  • Mar
    13

    Winter Classes End

    University Academic Calendar

    All Day

    EVENT DETAILS

    TIME Saturday, March 13, 2021

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Mar
    15

    Winter Examinations Begin

    University Academic Calendar

    All Day

    EVENT DETAILS

    TIME Monday, March 15, 2021

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Mar
    20

    Spring Break Begins

    University Academic Calendar

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    EVENT DETAILS

    TIME Saturday, March 20, 2021

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Mar
    26

    Winter Degrees Conferred

    University Academic Calendar

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    EVENT DETAILS

    TIME Friday, March 26, 2021

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Mar
    29

    Spring Break Ends

    University Academic Calendar

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    EVENT DETAILS

    TIME Monday, March 29, 2021

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Mar
    30

    Spring Classes Begin 8 a.m. Classes remote until Tuesday, April 6.

    University Academic Calendar

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    EVENT DETAILS

    TIME Tuesday, March 30, 2021

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Mar
    31

    SPREE Seminar: Raudel Avila

    McCormick - Civil and Environmental Engineering

    11:00 AM

    EVENT DETAILS

    TIME Wednesday, March 31, 2021 at 11:00 AM - 12:00 PM

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    CONTACT Tierney Acott    tierney.acott@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering

  • Apr
    14

    SPREE Seminar: Ryan Hurley

    McCormick - Civil and Environmental Engineering

    11:00 AM

    EVENT DETAILS

    TIME Wednesday, April 14, 2021 at 11:00 AM - 12:00 PM

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    CONTACT Tierney Acott    tierney.acott@northwestern.edu EMAIL

    CALENDAR McCormick - Civil and Environmental Engineering