News & Events
Department Events

Events

  • Apr
    11

    ChBE Seminar Series: "Combinatorial and evolutionary engineering of probiotic yeast for in situ biomanufacturing" - Nathan Crook, North Carolina State University

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    ChBE Seminar Series:

    The Chemical and Biological Engineering Department is pleased to present a seminar by Nathan Crook from North Carolina State University as part of our ChBE Seminar Series.

    Dr. Nathan Crook will present a seminar titled "Combinatorial and evolutionary engineering of probiotic yeast for in situ biomanufacturing.”

    ABSTRACT: The large intestine is the site of many human diseases yet is difficult to access with orally- or intravenously delivered drugs. At the same time, the gut provides a habitat for a numerous and diverse population of microbes (viral, prokaryotic, and eukaryotic) that perform important, health-relevant chemistries using host- and diet-derived carbohydrates as a feedstock. Therefore, there has been a rising interest in genetically engineering these gut microbes to produce therapeutic molecules in the gut, ultimately improving drug delivery and reducing drug costs. Saccharomyces boulardii (Sb) is a widely used yeast probiotic, demonstrating effectiveness against various gastrointestinal disorders. As a yeast, Sb exhibits high rates of protein secretion, is tolerant to low pH, can be freeze-dried, and low (if any) rates of horizontal gene transfer. Sb is therefore a promising chassis for development of personalized engineered probiotic medicines. In this talk, I will discuss our lab’s recent progress in tuning four key parameters of Sb’s efficacy as a drug delivery vehicle. First, I will present the development of a constitutive Sb promoter library, and how we applied this library to synthesize β-carotene in the mouse gut. Then, I will introduce how sensing of extracellular metabolites may be achieved through repair of Sb’s defective mating pathway and the expression of human adenosine and melatonin G protein-coupled receptors. I will next detail our efforts to enhance Sb’s in vivo residence time through both rational and screening-based approaches. Finally, I will discuss some new work from our lab focusing on the engineering and optimization of protein secretion titers in Sb, culminating in a quadruple knockout strain with a 10-fold increase to recombinant peptide production. Taken together, this work establishes Sb as a genetically tractable commensal fungus and demonstrates the tunable delivery of small-molecule and protein therapeutics during colonization.

    Dr. Crook received his B.S. in Chemical Engineering from the California Institute of Technology in 2009, and his Ph.D. in Chemical Engineering from the University of Texas at Austin in 2014, studying under Dr. Hal Alper. He pursued postdoctoral studies in Pathology and Immunology at Washington University in Saint Louis School Medicine from 2014-2017 in the lab of Dr. Gautam Dantas. Dr. Crook joined the department of Chemical and Biomolecular Engineering at NCSU in January 2018, and his lab focuses on how to engineer microbial communities. He received an NSF CAREER award and NIH New Innovator Award in 2023, and mentors 10 amazing graduate students and 3 amazing postdocs.

    Bagels and coffee will be provided at 9:30am, and the seminar will start at 9:40am. Please plan to arrive on time to grab a bagel and mingle!

    *Please note that there will be no Zoom option for seminars this year.

    more less

    TIME Thursday, April 11, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • Apr
    18

    ChBE Seminar Series: "Ion Migration in Metal Halide Perovskites: Implications for Solar Cell Stability" -Prashant Kamat, University of Notre Dame

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    TIME Thursday, April 18, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • Apr
    24

    BTP Seminar Series: Pratima Cherukuri, Genezen

    McCormick-Chemical and Biological Engineering (ChBE)

    12:00 PM LR4, Technological Institute

    EVENT DETAILS

    TIME Wednesday, April 24, 2024 at 12:00 PM - 2:00 PM

    LOCATION LR4, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Jennifer Young    jennifer.young@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • Apr
    25

    ChBE Seminar Series: From, "Will this be on the exam?" to "I enjoyed learning": Motivating Chemical Engineering Education Contexts - Allison Godwin, Cornell University

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    TIME Thursday, April 25, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    2

    ChBE Seminar Series: "Interfacial colloidal interactions, dynamics, and assembly: from biomembranes to ordered 2D materials" - Peter Beltramo, University of Massachusetts

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    TIME Thursday, May 2, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    8

    Extending Care: A Conversation about Conservation and Futurity

    Block Museum of Art

    6:00 PM Block Museum of Art, Mary and Leigh

    EVENT DETAILSmore info

    TIME Wednesday, May 8, 2024 at 6:00 PM - 7:30 PM

    LOCATION Block Museum of Art, Mary and Leigh    map it

    ADD TO CALENDAR

    CONTACT Block Museum of Art    block-museum@northwestern.edu EMAIL

    CALENDAR Block Museum of Art

  • May
    9

    ChBE Seminar Series: Influence of visible photons on catalytic reactions at metal nanoparticle surfaces - Phillip Christopher, University of California, Santa Barbara

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    TIME Thursday, May 9, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    16

    35th Annual Hugh M. Hulburt Memorial Lecture: "Adsorption Thermodynamics for Process Simulation" - Chau-Chyun Chen, Texas Tech University

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4 (M113), Technological Institute

    EVENT DETAILS

    TIME Thursday, May 16, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4 (M113), Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Jennifer Young    jennifer.young@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    23

    ChBE Seminar Series: ARDEI Annual Lecture | Christine Reyna, DePaul University

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    TIME Thursday, May 23, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • May
    30

    ChBE Seminar Series: Ruihan Li and Kunhuan Liu, Student Seminars

    McCormick-Chemical and Biological Engineering (ChBE)

    9:30 AM LR4, Technological Institute

    EVENT DETAILS

    TIME Thursday, May 30, 2024 at 9:30 AM - 10:45 AM

    LOCATION LR4, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Olivia Wise    olivia.wise@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering (ChBE)

  • Jun
    10

    Northwestern Engineering PhD Hooding and Master's Degree Recognition Ceremony

    McCormick School of Engineering and Applied Science

    9:00 AM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 9:00 AM - 11:00 AM

    LOCATION Welsh-Ryan Arena   

    ADD TO CALENDAR

    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Jun
    10

    Northwestern Engineering Undergraduate Convocation

    McCormick School of Engineering and Applied Science

    2:00 PM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 2:00 PM - 4:00 PM

    LOCATION Welsh-Ryan Arena   

    ADD TO CALENDAR

    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science