News & Events / BME Seminar Series / Past Seminar Speakers / 2018-19Peng Yin
BME Seminar Series Winter 2019
Thursday, January 24, 2019 at 4-5 pm
Tech L361
Host: Professor Hao Zhang
Professor of Systems Biology, Harvard Medical School
Core Faculty Member, Wyss Institute for Biologically Inspired Engineering, Harvard University
Biomolecular Analysis with DNA Probes
I'll discuss how to use DNA/RNA to construct nanostructures and develop applications especially for biomolecular analysis. We have developed a framework to synthesize DNA/RNA nanostructures with user-specified geometry or dynamics. By interfacing these nanostructures with other functional materials, we have introduced digital programmability into diverse application areas including inorganic nanofabrication, synthetic biology, and bioimaging. In particular, I will describe techniques for high precision super-resolution imaging using diffusing fluorescent DNA strands, multiplexed signal amplification method for high throughput and sensitivity tissue imaging, and a biochemical DNA nanoscope that encodes the spatial arrangement of molecular targets in autonomously produced DNA proximity records. I will also discuss current and prospective biological applications of these techniques, including single-cell nucleus architecture study, single molecule proteomics, and biomarker tissue mapping. For more details of our work, see http://molecular.systems.