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Postdoctoral Positions

Postdoctoral Fellow—Regenerative Engineering

The Center for Advanced Regenerative Engineering (CARE) at Northwestern University (Evanston, IL) has two post-doctoral associate positions available in the areas of musculoskeletal, bladder, and cardiovascular regenerative engineering research. Successful candidates will join a dynamic and multidisciplinary research team of researchers working on the following: a) development and evaluation of polymeric biomaterials for regenerative scaffolds, b) the integration of regenerative scaffolds with  their conformal electronics to enable sensing and actuation, c) use of patient-derived induced pluripotent stem cells (iPSCs) for regenerative therapies, and d) the engineering of transplant sites for the optimal engraftment of pancreatic islets. Applications will be considered immediately upon receipt and on a rolling basis through October 31, 2019.

Qualifications: PhD degree in Bioengineering/Biomedical Engineering/Chemical Engineering/Chemistry or a field related closely related to the research described above; At least two published 1st-author publications in peer-reviewed journals within the past 2 years; Strong oral and written communication skills. Preference will be given to candidates with a track record of publications/research productivity in the following areas of specialization: biomaterials for tissue engineering, orthopaedics research, cardiovascular research, stem cell technology, and polymer design, synthesis, and characterization.

Interested candidates should send a combined PDF with a cover letter describing their research interests, CV, and three professional references to Guillermo Ameer, Sc.D., Director of the Center for Advanced Regenerative Engineering (g-ameer@northwestern.edu).

Northwestern University is an equal opportunity employer. 

Posted 10/9/2019

ARMS Lab biomechanics Post-Doctoral Fellow

A Post-Doctoral Fellow, Research position is now available to pursue the study of biomechanics of baseball pitching in the Department of Biomedical Engineering, in the McCormick School of Engineering at Northwestern University. The successful candidate must have expertise in a field related to musculoskeletal biomechanics, neuromuscular control, and dynamics of human movements. Prior experience with 3D motion analysis is required; candidates with a demonstrated capacity for quantitative analysis of biomechanical human performance data, especially during high-level performance or sports, will be preferred. Prior experience with biomechanical modeling and simulation will also be considered an important strength.

The position is with the Applied Research in Musculoskeletal Simulation (ARMS) Lab, directed by Professor Wendy Murray. In addition to the McCormick School of Engineering and Applied Sciences, the lab is affiliated with Northwestern University Feinberg School of Medicine, and the Edward Hines Jr., VA Hospital in Hines, IL. The laboratory is physically located in downtown Chicago at the Shirley Ryan AbilityLab, where the successful candidate will also be appointed as a researcher.

The successful candidate will be a part of an interdisciplinary research team engaged in both experimental and computer simulation studies. The ARMS Lab is well-known for work that spans quantification of muscle structure, muscle activity, strength, and function in the upper limb. Simulation work in the lab involves the development, implementation, and interpretation of simulations driven by novel experimental data.

The initial contract for this position is for one year and may be renewable based on evaluation of performance and progress toward the research objectives.

Applications should be sent directly to w-murray@northwestern.edu and should include:

  • The applicant’s CV
  • PDFs of any relevant published works for which the applicant is a primary author

Postdoctoral Research Associate in Synthetic Cell Design

Project summary: The Kamat lab is seeking a motivated recent or pending PhD graduate for a project focused on designing a synthetic cell. This NSF sponsored project will investigate strategies to optimize a cell-free biochemical reaction in synthetic vesicles. The project is a collaboration between the labs in Northwestern’s Center of Synthetic Biology (Kamat, Tullman-Ercek, Bagheri, Jewett, Lucks, Leonard, Tyo, Prindle, and Mrksich) that will involve the use of cell-free extracts, compartmentalization strategies using bacterial microcompartments and bilayer vesicles, and machine learning techniques. The postdoctoral associate will use a multidisciplinary approach to construct bilayer vesicles and encapsulate cell-free expression systems. They will conduct gene expression analysis, biophysical characterization of membranes, and imaging analysis in order to optimize structural and chemical features of synthetic vesicles and carry out a multi-step biochemical reaction. The project will focus on answering the following key questions:

  1. How does segregation of cell-free expression components and select enzymes involved in a multi-step pathway influence the kinetics of the reaction and yield of desired biochemical product?
  2. How can vesicle membranes be designed to selectively control the transport of key substrates and biochemical intermediates such that a biochemical reaction is optimized?
  3. How can bacterial microcompartments be designed to segregate select enzymes to make specific intermediate products in a biochemical reaction?
  4. How can the temporal dynamics of a biochemical reaction be controlled through careful design of vesicle and bacterial compartments?

Suggested qualifications: Qualified applicants should have a completed PhD in the area of synthetic biology, bioengineering, chemical engineering, membrane biophysics, or a similar field. Some experience with cell-free expression techniques, molecular biology techniques, and vesicle assembly and characterization techniques is important. Experience with microfluidic techniques is encouraged but not required.

 To apply, please send your CV, a list of 3 references, and a cover letter to Neha Kamat (nkamat@northwestern.edu).

Posted 10/9/2019

Postdoctoral Opportunities - Optics

The Center for Physical Genomics and Engineering is a pioneer in the development of novel super-resolution imaging and nano-sensing technologies, and currently has two optics-related openings for postdoctoral fellows. For either role, candidates must have a Ph.D. in biomedical engineering, electrical engineering, medical physics, or a related field. The successful candidates are expected to possess excellent written and oral communication skills in English, a good publication record in peer-reviewed journals, and be highly motivated with demonstrable experience in modern optics.

One position is focused on developing endoscopic optical coherence tomography (OCT) technologies to quantitatively study changes to microvascular function and tissue nanoscale organization in response to disease progression. Candidates must have experience in optical imaging device development, fiber optics, spectroscopy, and Matlab or Python. Strong preference will be given to candidates with postdoctoral training and/or experience with optical coherence tomography, endoscopic imaging, broadband light sources, fiber optic splicing, machine learning techniques, and modeling of optical systems (Zemax). Demonstrated creativity through patents and novel high impact publications is a plus.

The second position is focused on super-resolution microscopy and single molecule localization techniques. Candidates must have experience in optical microscopy development, design and use; strong preference will be given to candidates with postdoctoral training and/or experience in the fields of super-resolution microscopy (especially single molecule localization techniques), spectral microscopy and/or other nanoscale imaging techniques. Experience with immuno-fluorescence and cell preparation is desired.

Successful candidates will work under the direction of Dr. Vadim Backman, Walter Dill Scott Professor of Biomedical Engineering, Professor of Medicine (Oncology) and Molecular Genetics, and Director of the Center for Physical Genomics and Engineering at Northwestern University.

Outstanding candidates interested in this opportunity are encouraged to send a CV to Benjamin Keane at: b-keane@northwestern.edu.

Posted 10/9/2019

Group Leader in Cancer Biology

 Note: Applicants for this position must have a PhD and direct experience in cancer biology and/or chromatin research.

The Center for Physical Genomics and Engineering at Northwestern University, directed by Prof. Vadim Backman, is seeking a postdoctoral fellow or research faculty to lead a multidisciplinary team of scientists conducting cutting-edge research at the crossroads of biology, genomics, physics, engineering and medicine. Our main goal is to investigate fundamental biological questions and develop novel approaches relevant to the prevention, detection, diagnosis and treatment of cancer and other currently intractable diseases at early, treatable stages. We have developed a platform of pioneering super-resolution and nano-sensing optical microscopy technologies which, combined with genome mapping and other functional genomic approaches, allow us to study the causal relationship between the nanoscale structure of chromatin, global patterns of gene expression, and their alteration in disease.

As evidenced by recent publications in Nature Biomedical Engineering, PNAS, Cancer Research, and Scientific Reports, the Center undertakes systematic approaches to understanding cancer development by integrating molecular dynamics simulations, live cell super-resolution nano-imaging, computational genomics, and genome mapping technologies.

The Center has received substantial sponsored and philanthropic support and provides a highly collaborative, transdisciplinary environment consisting of researchers with diverse backgrounds: biomedical engineering, molecular biology, computer science, physics, chemical engineering, etc. Additionally, the Center has collaborative projects with over 20 physicians, biomedical, and physical sciences investigators both internationally and domestically. Research projects reside within one or more priority areas: cancer biology, biophysics of the genome, or cancer therapeutics.

We are seeking a highly motivated, enthusiastic, and creative candidate with excellent interpersonal skills and a strong publication record. The successful candidate(s) will have the opportunity to conduct cutting-edge research integrating molecular biology, epigenetics, and computational genomics. It is anticipated that he/she will engage in preparation of original manuscripts for conferences and peer- reviewed journals as well as participate in writing grant proposals.

Specifically, you will:

  • Supervise and coordinate teams of graduate students and technicians working in the different areas of the research project.
  • Analyze and integrate large datasets, including genomics and transcriptomics.
  • Integrate molecular and physical aspects of genome function.
  • Perform ex vivo and in vitro cell culture and in vivo animal studies.

Qualifications: The Center seeks applicants with a strong background in cancer biology. Successful candidates will have a mixture of the following skills:

  1. Degree: PhD or MD/PhD required, with proven experience in cancer biology research.
  2. Prior experience:
    1. 3 years’ experience in cancer biology or chromatin research.
    2. Proficiency using standard biochemical, molecular, cellular, and functional genomic techniques is required.
    3. Prior experience with optical imaging techniques is desired.
    4. Prior experience with whole cell imaging and computational skills are preferred but not required.
    5. Experience in single cell data analyses and integrative multi-omics approaches is highly desired.
    6. Demonstrated technical capability in analyzing complex omics data, including transcriptomics, proteomics, and metabolomics; including differential analysis of multivariate datasets using common software tools.
    7. Previous experience with systems biology approaches to integrating omics datasets into biological pathways/networks, i.e., biological network modelling preferred but not required.
    8. Programming experience (preferably in Matlab and/or Mathematica) is preferred but not necessary.
    9. Experience working with mouse models is a plus.
    10. High level of numeracy and knowledge of statistical analysis is highly desired.
  3. Proven track record working independently and demonstrating critical thinking, problem solving; attention to detail; and creativity are essential.
  4. Excellent prioritization and project management skills.
  5. Strong communication and interpersonal skills and fluency in both spoken and written English.
  6. A solid record of quality publications in peer-reviewed journals showing an output commensurate with opportunity.

Qualified candidates should send a CV and cover letter to Benjamin Keane at
b-keane@northwestern.edu.

Posted 10/9/2019

Postdoctoral Fellow - Regenerative Engineering

The Center for Advanced Regenerative Engineering (CARE) at Northwestern University (Evanston, IL) is seeking to hire a postdoctoral fellow specializing in cardiovascular regenerative engineering. The successful candidate will join a dynamic and multidisciplinary research team focusing on the use of patient-derived induced pluripotent stem cells (iPSCs) for regenerative therapies and disease modeling. Specifically, the projects will involve clinical translational research in vascular bioengineering and regeneration, including the manufacturing of clinical-grade stem cell products, in vitro disease modeling and high throughput drug screening, and non-invasive, cell tracking via advanced molecular imaging. Applications will be considered immediately and on a rolling basis through Fall 2019.

Qualifications: PhD degree in Bioengineering / Biomedical Engineering or a closely related field; and strong oral and written communication skills are required. Preferred candidates will have research background/interests in the following fields: tissue engineering, cardiovascular medicine, cell biology, iPS cell technology, drug screening, non-invasive imaging, biomaterial design and characterization, and animal models of disease.

Interested candidates should send a combined PDF with a cover letter describing their research interests, CV, and three professional references to Bin Jiang, PhD (bin.jiang@northwestern.edu).

Northwestern University is an equal opportunity employer.

Posted 7/28/2019

Postdoctoral Position in Retinal Microenvironment and Metabolism

A postdoctoral position is available to study the microenvironment and metabolism of the isolated mammalian retina. The overall goal of the NIH-funded project is to use microelectrodes that measure oxygen, ions, and the electroretinogram, coupled with mathematical modeling, to obtain information on the spatial distribution of metabolic processes across the retina. The ideal candidate would have experience in neuroscience, ideally electrophysiology of the retina, and an interest in mathematical modeling of transport processes. The laboratory is situated in an environment at Northwestern University with strengths in visual science, neuroscience and biomedical engineering.

The position is available December 1, 2019 and will remain open until filled. Please direct questions, or send a resume and cover letter, to Robert Linsenmeier (r-linsenmeier@northwestern.edu).

Posted 10/9/2019

Graduate Student Position Available - Functional Genomics in Cancers

The laboratory of Dr. Zhe Ji at Northwestern University (https://sites.northwestern.edu/jilab/) seeks Ph.D. students working on the regulation of gene transcription and RNA translation in cancers. The lab is affiliated with the Department of Biomedical Engineering at McCormick School of Engineering and the Department of Pharmacology at Feinberg School of Medicine. Our group uses cutting-edge high-throughput genomic technologies, such as single-cell RNA-seq, ribosome profiling, ATAC-seq, ChIP-seq and CLIP-seq, and computational modeling to identify key genes and associated regulatory circuits underlying oncogenic processes. We aim to reveal novel cancer therapeutic strategies for precision medicine and immunotherapy. The students can choose to work on experimental and/or computational genomics.

Interested candidates should send a CV and cover letter to Dr. Zhe Ji (zhe.ji@northwestern.edu).

Posted 10/9/2019