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  • Dec
    7

    IEMS Seminar: Multiple Testing in Clinical Trials

    Department of Industrial Engineering and Management Sciences

    11:00 AM Hive 2.350, Ford Motor Company Engineering Design Center

    EVENT DETAILS

    Ajit Tamhane, Ph.D.

    Multiple Testing in Clinical Trials

    Abstract: In this talk I will give an overview of some multiple testing problems in clinical trials that I have worked on in recent years. These problems came to me through some consulting work and have led to interesting theoretical developments resulting in publications in the top journals in the field (listed below in the references).

    First I will review some basic concepts in multiple testing such as familywise error rate control, closed testing, group sequential designs and graphical methods. Then I will apply these concepts to the general problem of hierarchical (gatekeeping) testing of primary and secondary endpoints in a group sequential clinical trial. I will consider in some detail three special cases of this general problem.

    The focus of the talk will be the ideas behind the results and not the technical proofs. As such, this talk should be accessible to all.

    References:

    1. Tamhane, A. C., Mehta, C. R. and Liu, L. (2010), “Testing a primary and a secondary endpoint in a group sequential design,” Biometrics, 66, 1174-1184.

    2. Tamhane, A. C., Wu, Y. and Mehta, C. R. (2012), “Adaptive extensions of a two-stage group sequential procedure for testing a primary and a secondary endpoint (I): Unknown correlation between the endpoints,” Statistics in Medicine, 31, 2027-2040.

    3. Tamhane, A. C., Gou, J., Jennison, C. Mehta, C. R. and Curto, T. (2018), ``A gatekeeping procedure for testing a primary and a secondary endpoint in a group sequential design with multiple interim looks,'' Biometrics, 74. 40-48.

    Bio:

    Ajit Tamhane is Professor of Industrial Engineering & Management Sciences (IEMS) with a courtesy appointment in Statistics at Northwestern University.

    He has published over 100 papers in peer-reviewed journals in the areas of multiple testing, design of experiments, ranking and selection procedures, chemometrics and other related areas. He has authored or coauthored four books and co-edited two volumes of research papers..

    He is an elected fellow of the American Statistical Association (1991), the Institute of Mathematical Statistics (2010), the American Association for Advancement of Science (2013) and an elected member of the International Statistical Institute (2015).

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    TIME Tuesday, December 7, 2021 at 11:00 AM - 12:00 PM

    LOCATION Hive 2.350, Ford Motor Company Engineering Design Center    map it

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    CONTACT Agnes Kaminski    a-kaminski@northwestern.edu EMAIL

    CALENDAR Department of Industrial Engineering and Management Sciences

  • Jan
    20

    IEMS Seminar 1/20 Yonatan Mintz Winter 2026

    Department of Industrial Engineering and Management Sciences (IEMS)

    11:00 AM A230, Technological Institute

    EVENT DETAILSmore info

    TIME Tuesday, January 20, 2026 at 11:00 AM - 12:00 PM

    LOCATION A230, Technological Institute    map it

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    CONTACT Kendall Minta    kendall.minta@gmail.com EMAIL

    CALENDAR Department of Industrial Engineering and Management Sciences (IEMS)

  • Jan
    27

    IEMS Seminar 1/27 Bryon Aragam Winter 2026

    Department of Industrial Engineering and Management Sciences (IEMS)

    11:00 AM TBD, Technological Institute

    EVENT DETAILSmore info

    TIME Tuesday, January 27, 2026 at 11:00 AM - 12:00 PM

    LOCATION TBD, Technological Institute    map it

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    CONTACT Kendall Minta    kendall.minta@gmail.com EMAIL

    CALENDAR Department of Industrial Engineering and Management Sciences (IEMS)

  • Feb
    3

    IEMS Seminar 02/03 Kibaek Kim Winter 2026

    Department of Industrial Engineering and Management Sciences (IEMS)

    11:00 AM TBD, Technological Institute

    EVENT DETAILSmore info

    TIME Tuesday, February 3, 2026 at 11:00 AM - 12:00 PM

    LOCATION TBD, Technological Institute    map it

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    CONTACT Kendall Minta    kendall.minta@gmail.com EMAIL

    CALENDAR Department of Industrial Engineering and Management Sciences (IEMS)

  • Feb
    10

    IEMS Seminar 2/10 Feng Ruan Winter 2026

    Department of Industrial Engineering and Management Sciences (IEMS)

    11:00 AM TBD, Technological Institute

    EVENT DETAILSmore info

    TIME Tuesday, February 10, 2026 at 11:00 AM - 12:00 PM

    LOCATION TBD, Technological Institute    map it

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    CONTACT Kendall Minta    kendall.minta@gmail.com EMAIL

    CALENDAR Department of Industrial Engineering and Management Sciences (IEMS)

  • Feb
    17

    IEMS Nemhauser and Nelson Best Student Paper Seminar

    Department of Industrial Engineering and Management Sciences (IEMS)

    11:00 AM Technological Institute

    EVENT DETAILS

    TIME Tuesday, February 17, 2026 at 11:00 AM - 12:00 PM

    LOCATION Technological Institute    map it

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    CONTACT Kendall Minta    kendall.minta@gmail.com EMAIL

    CALENDAR Department of Industrial Engineering and Management Sciences (IEMS)

  • Mar
    3

    IEMS Seminar 03/03 Shane Henderson Winter 2026

    Department of Industrial Engineering and Management Sciences (IEMS)

    11:00 AM TBD, Technological Institute

    EVENT DETAILSmore info

    TIME Tuesday, March 3, 2026 at 11:00 AM - 12:00 PM

    LOCATION TBD, Technological Institute    map it

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    CONTACT Kendall Minta    kendall.minta@gmail.com EMAIL

    CALENDAR Department of Industrial Engineering and Management Sciences (IEMS)

  • Mar
    10

    IEMS Seminar 3/10 Nabarun Deb Winter 2026

    Department of Industrial Engineering and Management Sciences (IEMS)

    11:00 AM TBD, Technological Institute

    EVENT DETAILSmore info

    TIME Tuesday, March 10, 2026 at 11:00 AM - 12:00 PM

    LOCATION TBD, Technological Institute    map it

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    CONTACT Kendall Minta    kendall.minta@gmail.com EMAIL

    CALENDAR Department of Industrial Engineering and Management Sciences (IEMS)