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Mar28
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Imaging tissues, cells and nanoparticles in 3-D with electron probes
By: Richard Leapman
Abstract: Scanned electron probes can be used to characterize inorganic, organic and biological structures, as well as the interfaces between them in 3-D at the nanoscale. Here, we illustrate the application of scanning transmission electron microscopy (STEM), electron energy loss spectroscopy (EELS), electron tomography (ET), and serial block face scanning electron microscopy (SBF-SEM) to study tissues, cells, and bionanoparticles. The use of focused probes offers important advantages for determining 3-D cellular architecture since it is possible to optimise signals generated by the interaction between the incoming electrons and the specimen. In particular, axial bright-field STEM-tomography, and serial block face SEM are proving valuable for quantitative 3-D ultrastructural analysis of cells and tissues. For example, we have applied these approaches quantitatively to study ultrastructural changes that occur in blood platelets when they are activated, the arrangement of organelles in homone-secreting cells in pancreatic islets of Langerhans, and the interface between osteocytes and mineralised matrix in bone formation. The ability to synthesize multicomponent hybrid nanocarriers with controlled architecture and chemical functionality offers great potential for developing in vivo and ex vivo medical diagnostics and therapeutics. For example, we have used a combination of STEM, EELS and ET to characterise plasmonic gold nanovesicles designed for photothermal therapy, optical nanosensors that detect enzymes expressed by cancer cells, and nanocomplexes taken up by stem cells as magnetic labels for MRI imaging.
Bio: Richard Leapman obtained his B.A. and M.A. degrees in Natural Sciences, and his Ph.D. in physics from the University of Cambridge. He trained as a postdoctoral fellow in the Department of Materials at the University of Oxford, and then under the mentorship of Prof. John Silcox in the Department of Applied and Engineering Physics at Cornell University, where he contributed to the development of electron spectroscopy for the nanoscale characterization of materials. Dr. Leapman subsequently moved to NIH to develop methods based on scanning transmission electron microscopy and electron spectroscopy to determine the structure and chemical composition of cells and supramolecular assemblies. More recently, his group has developed techniques based on STEM tomography for determining 3D ultrastructure in thick sections of cells, as well as serial block face SEM approaches for determining nanoscale tissue architecture. Dr. Leapman received the Burton Medal from the Microscopy Society of America, the Samuel Wesley Stratton Award from the National Institute of Standards and Technology, and the Presidential Science Award from the Microbeam Analysis Society.
TIME Tuesday, March 28, 2017 at 4:00 PM - 5:00 PM
LOCATION L361 Technological Institute map it
CONTACT Department Office matsci@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering
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Apr29
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Brought to you by the MSE Resource Center & MSE Finance Team
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-Policy & ProceduresTIME Monday, April 29, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May2
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-Policy & ProceduresTIME Thursday, May 2, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May6
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-Policy & ProceduresTIME Monday, May 6, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May8
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lessThe Center for Scientific Studies in the Arts is a collaboration between the Art Institute of Chicago and materials science-related departments at Northwestern University to pursue objects-based and objects-inspired scientific research. Materials research benefits ongoing work in conservation, archaeology, art history, and curatorial scholarship.
Learn how the Center uses materials research to care for art objects in sustainable, innovative ways with Maria Kokkori, Senior Scientist in the Center for Scientific Studies in the Arts. She will be in conversation with Corey Byrnes, Northwestern Associate Professor of Chinese Culture and co-founder/co-director of the Environmental Humanities Workshop in Kaplan Humanities Center.
This event is presented by the McCormick School of Engineering and Applied Science in conjunction with exhibition Actions for the Earth: Art, Care & Ecology.
TIME Wednesday, May 8, 2024 at 6:00 PM - 7:30 PM
LOCATION Block Museum of Art, Mary and Leigh map it
CONTACT Block Museum of Art block-museum@northwestern.edu EMAIL
CALENDAR Block Museum of Art
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May9
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-Policy & ProceduresTIME Thursday, May 9, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May13
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-Policy & ProceduresTIME Monday, May 13, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May16
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-Policy & ProceduresTIME Thursday, May 16, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May20
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-Policy & ProceduresTIME Monday, May 20, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May23
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-Policy & ProceduresTIME Thursday, May 23, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May27
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-Policy & ProceduresTIME Monday, May 27, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May30
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-Policy & ProceduresTIME Thursday, May 30, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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Jun10
EVENT DETAILSmore info
lessMcCormick School of Engineering PhD Hooding and Master’s Degree Recognition Ceremony
TIME Monday, June 10, 2024 at 9:00 AM - 11:00 AM
LOCATION Welsh-Ryan Arena
CONTACT Amy Pokrass amy.pokrass@northwestern.edu EMAIL
CALENDAR McCormick School of Engineering and Applied Science
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Jun10
TIME Monday, June 10, 2024 at 2:00 PM - 4:00 PM
LOCATION Welsh-Ryan Arena
CONTACT Amy Pokrass amy.pokrass@northwestern.edu EMAIL
CALENDAR McCormick School of Engineering and Applied Science