Faculty Directory
Samuel Stupp

Board of Trustees Professor of Materials Science and Engineering, Chemistry, Medicine and Biomedical Engineering

Director, Simpson Querrey Institute for BioNanotechnology

Contact

2220 Campus Drive
Cook Hall 2036; Office - Cook 1127
Evanston, IL 60208

Email Samuel Stupp

Website

The Stupp Laboratory


Centers

Simpson Querrey Institute for BioNanotechnology

Center for Bio-Inspired Energy Science


Departments

Materials Science and Engineering

Biomedical Engineering

Education

Ph.D. Materials Science and Engineering, Northwestern University, Evanston, IL

B.S. Chemistry, University of California at Los Angeles, Los Angeles, CA


Research Interests

Research in the Stupp group integrates chemistry with materials science, biology, and medicine. The overarching interest of the group is the development of self-assembling organic materials, focusing on functions relevant to energy and medicine. In the area of energy science, the laboratory’s interests include, materials for solar photovoltaics, catalytic materials that can synthesize solar fuels, supramolecular ferroelectrics for non-volatile memories, and artificial muscle materials for inter-conversion of chemical and mechanical energy. In the area of medicine, the Stupp laboratory is interested in biomaterials for regenerative medicine of the brain, spinal cord, bone, cartilage and muscle, and also on targeted systemic drug delivery using nanostructures for cancer and cardiovascular applications. The organic structures of interest in both areas include, visible light absorbing chromophores, organometallic catalysts, electron donors and acceptors, DNA, peptides, glycopeptides, and polymers, among others. The group is organized into three sub-groups that meet weekly to discuss progress: Self-Assembly, Energy Materials, and Biomaterials. Research activities include, molecular synthesis, characterization of structure with a broad suite of microscopies and synchrotron x-ray scattering, measurement of materials properties, computer simulations, construction of solar cell and other electronic devices, molecular and cell biology, and in vivo studies of the efficacy of materials and nanostructures in biomedical applications.

Group members in the self-assembly subgroup focus on fundamental supramolecular chemistry and materials science aimed at learning how to program molecules to assemble into functional materials. The systems studied cover the broad range of molecular structures and functions of interest to the Stupp laboratory.

The energy materials sub-group is currently focused on materials for solar photovoltaic devices and hydrogels that can harvest light and use catalysts in their three dimensional structure to generate solar fuels such as hydrogen or to reduce carbon dioxide. An important area of interest in this sub-group are hybrid organic-inorganic materials for energy applications, including supercapacitors and dye-sensitized solar cells.

The biomaterials subgroup focuses on the development of bioactive materials for regenerative medicine that can directly signal cells. The chemical systems include self-assembling peptide amphiphiles, DNA nanotechnology, and biopolymers to design solid scaffolds or injectable nanostructures to create a bioactive artificial extracellular matrix. The targets include spinal cord regeneration to avoid paralysis, treatments for Parkinson’s disease, regeneration in the heart after infarct, and strategies to regenerate muscle, bone, and cartilage, among others. Other work in this sub-group focuses on nanostructures for use in systemic targeted therapies.

 


Significant Recognition

  • Highly Cited Researcher in Chemistry, Thomson Reuters Corporation (2014)
  • International Award, The Society of Polymer Science, Japan (2014)
  • President, International Scientific Committee of the Institute for Bioengineering of Catalonia, Spain (2014)
  • Distinguished Visiting Scientist of the Institute of Materials Research and Engineering, Singapore (2014)
  • Distinguished Visiting Professor of Biochemistry, University of Hong Kong (2014)
  • Creation of the Samuel I. Stupp Prize in Nanotechnology by the Ministry of Science and Technology, Government of Costa Rica (2013)
  • Honorary Doctorate from the University of Gothenburg, Sweden Medical School (2013)
  • Australian Centre for Nanomedicine Annual Visiting Professorship (2013)
  • American Chemical Society Ronald Breslow Award for Achievement in Biomimetic Chemistry (2012)
  • Member, National Academy of Engineering (2012)
  • Member, Royal Spanish Academy of Pharmacy (2012)
  • Honorary Doctorate, National University of Costa Rica (2011)
  • Thomson Reuters Top 100 Chemists for 2000-2010 (2011)
  • Fellow, Materials Research Society (2009)
  • Distinguished Professorship, Eindhoven University of Technology (2009)
  • Israel Pollack Distinguished Lecture Series Award, Technion-Israel Institute of Technology (2009)
  • Honorary Doctorate for Revolutionary Research in Complex Molecular Systems, Eindhoven University of Technology (2009)
  • American Chemical Society Award in Polymer Chemistry (2005)
  • Fellow, World Technology Network (2003)
  • Materials Research Society Medal Award (2000)
  • Humboldt Award for Senior U.S. Scientists (1997)
  • U.S. Department of Energy Prize for Outstanding Scientific Accomplishment in Materials Chemistry (1991)
  • Xerox Faculty Award for Excellence in Engineering Research (1985)
  • 3M Young Faculty Award (1981)
  • 3M Young Faculty Award (1981)
  • 3M Young Faculty Award (1981)

Significant Professional Service

  • Organizer and Co-Chair of the Inter-Agency Materials Genome Initiative Soft Matter Summit, Washington DC (2013)
  • Member, RIKEN Center for Emergent Matter Science Advisory Council, Japan (2013)
  • Member, Scientific Advisory Board, Xeltis Corporation, Zurich, Switzerland (2013)
  • Co-Chair, Gordon Research Conference on Self-Assembly & Supramolecular Chemistry in Les Diablerets, Switzerland (2013)
  • Honorary Membership, Israel Chemical Society (2009)
  • Member, World Premier International Program Advisory Committee to Advanced Institute for Materials Research, Japan Society for the Promotion of Science, Japan (2008)
  • International Advisory Group, Swedish Government Program on Biomaterials, Gothenburg University (2008)
  • Member, Scientific Advisory Board, University of Vienna (2006)
  • Merck-Karl Pfister Visiting Professorship, Massachusetts Institute of Technology (2004)
  • Member, Scientific Advisory Board, National University of Singapore (2003)
  • Member, Baxter Scientific Advisory Board (2001)
  • Member, Solid State Sciences Committee, National Academy of Sciences (2001)
  • Member, Basic Energy Sciences Advisory Committee, Department of Energy (1999)
  • Elected member of American Academy of Arts and Sciences (1998)
  • Fellow of American Association for the Advancement of Science (1999)
  • Joliot Curie Professorship, Ecole Supérieure de Physique et de Chimie Industrielles (1997)
  • Member, Materials Panel, Air Force Scientific Advisory Board (1995)
  • Exclusive consultant to 3M Company (1987)

Selected Publications

    Stephanopoulos, N.; Freeman, R.; North, H. A.; Sur, S.; Jeong, S. J.; Tantakitti, F.; Kessler, J, A.; Stupp, S. I. “Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons” Nano Letters 2015, 15(1), 603-609. 

    Lee, S. S.; Hsu, E. L.; Mendoza, M.; Ghodasra, J.; Nickoli, M. S.; Ashtekar, A.; Polavarapu, M.; Babu, J.; Riaz, R. M.; Nicolas, J. D.; Nelson, D.; Hashmi, S. Z.; Earhart, J. S.; Merk, B. R.; McKee, J. S.; Bairstow, S. F.; Shah, R. N.; Hsu, W. K.; Stupp, S. I. “Gel Scaffolds of BMP-2-binding Peptide Amphiphile Nanofibers for Spinal Arthrodesis” Advanced Healthcare Materials 2015, 4(1), 131-141. 

    Weingarten, A. S.; Kazantsev, R. V.; Palmer, L. C.; McClendon, M.; Koltonow, A. R.; Samuel, A. P. S.; Kiebala, D. J.; Wasielewski, M. R.; Stupp, S. I. “Self-Assembling Hydrogel Scaffolds for Photocatalytic Hydrogen Production” Nature Chemistry 2014, 6, 964-970. 

    Cui, H.; Cheetham, A. G.; Pashuck, E. T.; Stupp, S. I. “Amino Acid Sequence in Constitutionally Isomeric Tetrapeptide Amphiphiles Dictates Architecture of One-Dimensional Nanostructures” J. Am. Chem. Soc. 2014, 136(35), 12461-12468.

    Preslar, A. T.; Parigi, G.; McCLendon, M. T.; Sefick, S. S.; Moyer, T. J.; Haney, C. R.; Waters, E. A.; MacRenaris, K. W.; Luchinat, C.; Stupp, S. I.; Meade, T. J. “Gd(III)-Labeled Peptide Nanofibers for Reporting on Biomaterial Localization In Vivo”  ACS Nano 2014, 8(7), 7325-7332.

    Li, A.; Hokugo, A.; Yalom, A.; Berns, E. J.; Stephanopoulos, N.; McClendon, M. T.; Segovia, L. A.; Spigelman, I.; Stupp, S. I.; Jarrahy, R. “A Bioengineered Peripheral Nerve Construct Using Aligned Peptide Amphiphile Nanofibers” Biomaterials 2014, 35(31), 8780-8790.  

    Ortony, J. H.; Newcomb, C.; Matson, J. B.; Palmer, L. C.; Doan, P. E.; Hoffman, B. M.; Stupp, S. I. “Internal Dynamics of a Supramolecular Nanofiber” Nature Materials 2014, 13, 812-816.

    Boekhoven, J.; Stupp, S. I. “Supramolecular Materials for Regenerative Medicine” Advanced Materials 2014, 26(11), 1642-1659.  

    Newcomb, C. J.; Sur, S.; Ortony, J. H.; Lee, O-S.; Matson, J. B.; Boekhoven, J.; Yu, J-M.; Schatz, G. C.; Stupp, S. I. “ Cell Death Versus Cell Survival Instructed by Supramolecular Cohesion of Nanostructures” Nature Communications 2014, 5(3321), 1-10. 

    Berns, E. J.; Sur, S.; Pan, L.; Goldberger, J. E.; Suresh, S.; Zhang, S.; Kessler, J. A.; Stupp, S. I. “Aligned Neurite Outgrowth and Directed Cell Migration in Self-Assembled Monodomain Gels” Biomaterials 2014, 35(1), 185-195. 

    Lee, S. S.; Hunag, B. J.; Kaltz, S. R.; Sur, S.; Newcomb, C. J.; Stock, S. R.; Shah, R. N.; Stupp, S. I. “Bone Regeneration with Low Dose BMP-2 Amplified by Biomimetic Supramolecular Nanofibers within Collagen Scaffolds” Biomaterials 2013, 34(2), 452-459.            

    Ruff, Y.; Moyer, T.; Newcomb, C. J.; Demeler, B.; Stupp, S.I. “Precision Templating with DNA of a Virus Like Particle with Peptide Nanostructures” JACS 2013, 135(16), 6211-6219.

    Boekhoven, J.; Pérez, C. R.; Sur, S.; Worthy, A.; Stupp, S. I.; “Dynamic Display of Bioactivity through Host-Guest Chemistry” Angew. Chem. Int. Ed. 2013,52(46), 12077-12080. 

    Stephanopoulos, N.; Ortony, J. H.; Stupp, S. I. “Self-Assembly for the Synthesis of Functional Biomaterials” Acta Materialia 2013, 61(3), 912-930. 

    Zha, R. H.; Sur, S.; Stupp, S. I. “Self-Assembly of Cytotoxic Peptide Amphiphiles into Supramolecular Membranes for Cancer Therapy” Advanced Healthcare Materials 2013, 2(1), 126-133.

    Tayi, A. S.; Shveyd, A. K.; Sue, C-H.; Szarko, J. M.; Rolczynski, B. S.; Cao, D.; Kennedy, T. J.; Sarjeant, A. A.; Stern, C. L.; Paxton, W. F.; Wu, W.; Dey, S. K.; Fahrenbach, A. C.; Guest, J. R.; Mohseni, H.; Chen, L. X.; Wang, K. L.; Stoddart, J. F.; Stupp, S. I. “Room-Temperature Ferroelectricity in Supramolecular Networks of Charge-Transfer Complexes” Nature 2012, 488, 485-489.

    Aida, T.; Meijer, E. W.; Stupp, S. I. “Functional Supramolecular Polymers” Science 2012, 335(6070), 813-817. 

    Velichko, Y. S.; Mantei, J. R.; Bitton, R.; Carvajal, D.; Shull, K. R.; Stupp, S. I.  “Electric Field Controlled Self-Assembly of Hierarchically Ordered Membranes” Advanced Functional Materials 2012, 22(2), 369-377.

    Matson, J.; Stupp, S. I. “Self-Assembling peptide scaffolds for Regenerative Medicine” Chemical Communications 2012, 48(1), 26-33.

    Tevis, I. D.; Palmer, L. C.; Herman, D. J.; Murray, I. P.; Stone, D. A.; Stupp, S. I. “Self-Assembly and Orientation of Hydrogen-Bonded Oligothiophene Polymorphs at Liquid-Membrane-Liquid Interfaces” J. Am. Chem. Soc. 2011, 133(41), 16486-16494.

    Goldberger, J. E.; Berns, E. J.; Bitton, R.; Newcomb, C. J.; Stupp, S. I. “Electrostatic Control of Bioactivity” Angew. Chem. Int. Ed. 2011, 50(28), 6292-6295.

    Rożkiewicz, D. I.; Myers, B. D.; Stupp, S. I. “Interfacial Self-Assembly of Cell-like Filamentous Microcapsules” Angew. Chem. Int. Ed. 2011, 50(28), 6324-6327.

    Webber, M. J.; Tongers, J.; Newcomb, C. J.; Marquardt, K-T.; Bauersachs, J.; Losordo, D. W.; Stupp, S. I. “Supramolecular Nanostructures that Mimic VEGF as a strategy for Ischemic Tissue Repair” Proc. Natl. Acad. Sci. 2011, 108(33), 13438-13443.

    Huang, Z.; Newcomb, C. J.; Bringas, P.; Stupp, S. I.; Snead, M. L. “Biological Synthesis of Tooth Enamel Instructed by an Artificial Matrix” Biomaterials 2010, 31(35), 9202-9211. 

    Stupp, S. I. “Self-Assembly and Biomaterials” Nano Letters 2010, 10(12), 4783-4786. 

    Shah, R. M.; Shah, N. A.; Del Rosario Lim, M. M.; Hsieh, C.; Nuber, G.; Stupp,  S. I. “Supramolecular Design of Self-Assembling Nanofibers for Cartilage Regeneration” Proc. Natl. Acad. Sci. 2010, 107(8), 3293-3298.

    Mata, A.; Geng, Y.; Henrikson, K.; Aparicio, C.; Stock, S.; Satcher, R. L.; Stupp, S. I. “Bone Regeneration Mediated by Biomimetic Mineralization of a Nanofiber Matrix” Biomaterials 2010, 31(23), 6004-6012. 

    Pashuck, E. T.; Cui, H.; Stupp, S. I. “Tuning Supramolecular Rigidity of Peptide Fibers through Molecular Structure”J. Am. Chem. Soc. 2010, 132(17), 6041-6046. 

    Shah, R. M.; Shah, N. A.; Del Rosario Lim, M. M.; Hsieh, C.; Nuber, G.; Stupp,  S. I. “Supramolecular Design of Self-Assembling Nanofibers for Cartilage Regeneration” Proc. Natl. Acad. Sci. 2010, 107(8), 3293-3298.

    Zhang, S.; Greenfield, M. A.; Mata, A.; Palmer, L. C.; Bitton, R.; Mantei, J. R.; Aparicio, C.; Olvera de la Cruz, M.; Stupp, S. I. “A Self-Assembly Pathway to Aligned Monodomain Gels” Nature Materials 2010, 9(7), 594-601. 

    Cui, H.; Pashuck, E. T.; Velichko, Y. S.; Weigand, S. J.; Cheetham, A. G.; Newcomb, C. J.; Stupp, S. I. “Spontaneous and X-Ray Triggered Crystallization at Long Range in Self-Assembling Filament Networks” Science 2010, 327(5965), 555-559.

    Sofos, M.; Goldberger, J.; Stone, D. A.; Allen, J. E.; Ma, Q.; Herman, D. J.; Tsai. W-W.; Lauhon, L. J.; Stupp. S. I. “A Synergistic Assembly of Nanoscale Lamellar Photoconductor Hybrids” Nature Materials 2009, 8(1), 68-75.