Faculty DirectoryMark Johnson
Professor of Biomedical Engineering
Professor of Mechanical Engineering
Professor of Ophthalmology
Contact2145 Sheridan Road
Evanston, IL 60208-3109
Email Mark Johnson
Ph.D. Mechanical Engineering, MIT, Cambridge, MA
M.S. Mechanical Engineering, MIT, Cambridge, MA
B.S. Mathematics, Purdue University, West Lafayette, IN
B.S. Interdisciplinary Engineering, Purdue University, West Lafayette, IN
Dr. Johnson is internationally known for his work on ocular biomechanics, particular with regards to the pathogenesis of glaucoma and age-related macular degeneration. Studies in his group currently involve a bioengineering approach that utilizing perfusion studies, atomic force microscopy and theoretical analysis in combination with use of high-resolution morphometry and finite element modeling. Dr. Johnson has been involving in the study of a variety of physiological transport problems for the past 30 years including flow through the aqueous humor outflow pathways as relates to glaucoma, transport through the arterial wall, transport through the cornea, transport through macromolecular gels such as hyaluronic acid and Matrigel, and transport through Bruch’s membrane.
- BME 377: Intermediate Fluid Mechanics. Fundamental concepts of fluid dynamics. Kinematics, mass and momentum balances, constitutive relations. Navier-Stokes equations and methods of solution. Scaling techniques.
- BME 350/450: Transport Fundamentals. Fundamental and biomedical applications of diffusive and convective heat and mass transfer.
- BME 452: Transport Through Connective Tissues. Fluid flow and mass transfer applications through extracellular matrix. Porous media theory. Applications to drug transport.
Johnson, M. and Ethier, C. Ross: Problems for Biomedical Fluid Mechanics and Transport Phenomena, Cambridge University Press, 2014.
Johnson, M. and Erickson, K.: Mechanisms and routes of aqueous humor drainage. Principles and Practice of Ophthalmology, Volume I: Basic Sciences, chapter 11B, Ed. Albert , D.M. and Jakobiec, F.A., WB Saunders Co. Philadelphia, 2000.
Johnson, D. and Johnson, M.: How does non-penetrating glaucoma surgery work?, Non-Penetrating Glaucoma Surgery , Chapter 4, Ed. Mermoud, A. and Shaarawy, T., Martin Dunitz, Ltd., London, 2001 (reprinted from Journal of Glaucoma).
Freddo, T.F. and Johnson, M.: Conventional Aqueous Humor Outflow, in The Eye's Aqueous Humor, Ed. Mortimer Civan, Elsevier, 2008.
Johnson, M. and Tamm, E.R.: Biomechanics of aqueous humor outflow resistance., Encyclopedia of the Eye, Chapter 93, Academic Press, 2010.
Curcio, C.A. and Johnson, M.: Structure, function and pathology of Bruch's membrane., Retina, 6th Edition, Ed. David Hilton, Elsevier, 2017.
Selected Peer-Reviewed Papers (out of 67):
Curcio, CA, Johnson, M, Rudolf, M and Huang, J-D: The oil spill in ageing Bruch membrane, British Journal of Ophthalmology, 95:1638-1645, 2011.
Cankova, Z, Huang, J-D, Kruth, HS and Johnson, M: Passage of low-density lipoprotein through Bruch's membrane and choroid, Experimental Eye Research, 93:947-955, 2012.
Zhou, EN, Krishnan, R, Stamer, WD, Perkuman, K, Rejendran, K, Nabhan, JF, Lu, Q, Fredberg, JJ and Johnson, M: Mechanical responses of the endothelial cell of Schlemm's canal: Scope, variability and their potential role in controlling aqueous humor outflow, Journal of the Royal Society Interface, 9: 1144-1155, 2012.
Vargas-Pinto, R, Gong, H and Johnson, M: The effect of the endothelial cell cortex on atomic force microscopy measurements, Biophysical Journal, 105:300-309, 2013.
Overby, DR, Zhou,EH, Vargas-Pinto, R, Pedrigi, RM, Fuchshofer, R, Braakman, ST, Gupta, R, Perkumas,KM, Sherwood, JM, Vahabikashi, A, Dang, Q, Kim,JH, Ethier, CR, Stamer, WD, Fredberg, J and Johnson, M: Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma, Proceedings of the National Academy of Sciences, 111: 13876-13881, 2014.
Yang, C-Y, Huynh, T, Johnson, M and Gong, H: Endothelial glycocalyx layer in the aqueous outflow pathway of bovine and human eyes, Experimental Eye Research, 128: 27-33, 2014.
Vargas-Pinto,R, Lai, J, Gong, H, Ethier,CR, Johnson, M: Finite element analysis of the pressure-induced deformation of Schlemm's canal endothelial cells, Biomechanics and Modeling in Mechanobiology, 14:851-863, 2015.
Stamer, WD, Braakman, ST, Zhou, EH, Ethier, CR, Fredberg, JJ, Overby, DR, and Johnson, M: Biomechanics of Schlemm’s Canal Endothelium and Intraocular Pressure Reduction, Progress in Retinal and Eye Research, 44: 86-98, 2015.
Park, C-Y, Zhou, EH, Tambe, D, Chen, B, Lavoie, T, Dowell, M, Simeonov, A, Maloney, DJ, Marinkovic, A, Tschumperlin, DJ, Burger, S, Frykenberg, M, Butler, JP, Stamer, WD, Johnson, M, Solway, J, Fredburg, JJ and Krishnan, R: High-throughput screening for modulators of cellular contractile force, in press, Integrative Biology, 2015.
Johnson, M, McLaren, JW, and Overby, DR: Unconventional aqueous humor outflow: a review, in press in Experimental Eye Research, 2017.
In the Classroom
Professor Johnson's teaching philosophy centers on the importance of problem solving. All of his courses focus on this engineering skill. In collaboration with Professor Ross Ethier of Georgia Tech, he is publishing a book (through Cambridge University Press) on flow and transport problems that emphasizes these skills.
Accounting Specialist, Northwestern University