Faculty Directory
Danielle Tullman-Ercek


Ph.D Chemical Engineering, University of Texas - Austin, Austin, TX

B.S. Chemical Engineering, Illinois Institute of Technology, Chicago, IL

Research Interests

My group is interested in controlling the movement of materials across biological membranes, with a goal of enabling and enhancing the production of pharmaceuticals, biofuels, and materials in microbes. Manipulating the transport of electrons, small molecules, and even signals across these cellular boundaries is a vital component of most synthetic biology applications, and we are developing the tools and methods to engineer membrane proteins and other protein superstructures to meet this grand challenge.

Selected Publications

    Glasgow J.E., Asensio M.A., Jakobson C.M., Francis M.B., Tullman-Ercek D. (2015) “The influence of electrostatics on small molecule flux through a protein nanoreactor.” ACS Synth. Biol. 4(9):1011-9. 

    Jakobson C.M., Kim E.Y., Slininger M.F., Chien A., Tullman-Ercek D. (2015) “Localization of proteins to the 1,2-propanediol utilization microcompartment by non-native signal sequences is mediated by a common hydrophobic motif.” J. Biol. Chem. 290(40):24519-33.

    Azam A., Metcalf K.J., Li C., Tullman-Ercek D. (2016) “Type III secretion as a generalizable strategy for the development of peptide-based biomaterials.” Biotechnol. Bioeng. 113(11):2313-20.

    Boyarskiy S., Davis López S., Kong N., Tullman-Ercek D. (2016) “Transcriptional feedback regulation of efflux protein expression for increased tolerance to and production of n-butanol.” Metab. Eng. 33: 130-7.

    Jakobson C.M., Chen Y., Slininger M.F., Valdivia E., Kim E.Y., Tullman-Ercek D. (2016) “Tuning the catalytic activity of subcellular nanoreactors.” J. Mol. Biol. 28(15):2989-96.

    Asensio M., Morella N., Jakobson C.M., Hartman E.C., Glasgow J.E., Sankaran B., Zwart P.H., Tullman-Ercek D. (2016) “A single-point mutation in the capsid protein alters the assembled geometry of the bacteriophage MS2 capsid.” Nano Letters 16(9):5944-50.

    Glasgow A.A., Wong H.T., Tullman-Ercek D. (2017) “A secretion-amplification role for Salmonella enterica translocon protein SipD.” ACS Synth. Biol. 6(6):1006-1015.

    Slininger Lee M.F., Jakobson C.M., Tullman-Ercek D. (2017) “Evidence for Improved Encapsulated Pathway Behavior in a Bacterial Microcompartment through Shell Protein Engineering.” ACS Synth. Biol. 6(10):1880-1891.