McCormick School of Engineering, Northwestern University

Faculty Directory

Patrick F. Kiser

Visiting Associate Professor of Biomedical Engineering

Visiting Associate Professor of Obstetrics and Gynecology

2145 Sheridan Road

Tech E334

Evanston, IL 60208-3109

patrick.kiser( at )northwestern.edu

Education

Ph.D.    Mechanical Engineering and Materials Science, Duke University Durham, NC

M.S.     Chemistry, University of Wisconsin, Milwaukee, WI

B.S.      Chemistry and Philosophy, University of Wisconsin, Madison, WI


Research Interests

The primary focus of the Kiser research group is drug delivery technology for applications in women’s health. We are particularly interested in new antiviral agents and drug delivery systems to intercept sexually transmitted viruses at the point of interaction with the genital mucosa and the first target cells infected in the mucosa. Our methods include synthetic polymer chemistry, pharmaceutical chemistry, modeling drug transport, and using these results in drug delivery system design and prototyping. We perform preclinical toxicity efficacy evaluations in cell, tissue, and animal models; conduct antiviral assays and drug transport assays; and produce devices using a variety of pharmaceutical manufacturing technologies. Our projects range from new materials discovery that could lead to next generation mucosally active antiviral agents and mucosal vaccines, to the development of new assays to evaluate HIV prevention technologies, to sustained delivery system projects for antiviral, anti-infectives and contraceptive agents. The lab is funded by the NIH (NIAD), the Bill and Melinda Gates Foundation and USAID.


Selected Publications

    1. 1. James M. Smith, Rachna Rastogi, Ryan S. Teller, Priya Srinivasan, Pedro M. M. Mesquita, Umadevi Nagaraja, Janet M. McNicholl, R. Michael Hendry, Chuong T. Dinh, Amy Martin, Betsy C. Herold, and Patrick F. Kiser, Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges, PNAS, 2013, 110, no. 40, 16145–16150 (link)
    2. 2. Rachna Rastogi, Ryan S. Teller, Pedro M.M. Mesquita, Betsy C. Herold, Patrick F. Kiser, Osmotic pump tablets for delivery of antiretrovirals to the vaginal mucosa, Antiviral Research 2013, 100, 255–258 (link)
    3. 3. Justin T. Clark, Todd J. Johnson, Meredith R. Clark, Joel S. Nebeker, Judit Fabian, Anthony L. Tuitupou Satya Ponnapalli, Eric M. Smith, David R. Friend, Patrick F. Kiser, Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir , Journal of Controlled Release, 2012, 163, 240–248 (link)
    4. 4. Todd J. Johnson, Meredith R. Clark, Theodore H. Albright, Joel S. Nebeker, Anthony L. Tuitupou, Justin T. Clark, Judit Fabian, R. Tyler McCabe, Neelima Chandra, Gustavo F. Doncel, David R. Friend and Patrick F. Kiser, A 90-Day Tenofovir Reservoir Intravaginal ring for Mucosal HIV Prophylaxis, Antimicrob. Agents Chemother. 2012, 56(12):6272. (link)
    5. 5. Alamelu Mahalingam, Julie I. Jay, Kristofer Langheinrich, Shetha Shukair, Mike D. McRaven, Lisa C. Rohan, Betsy C. Herold, Thomas J. Hope, Patrick F. Kiser, Inhibition of the transport of HIV in vitro using a pH-responsive synthetic mucin-like polymer system, Biomaterials  2011, 32, 8343-8355 (link)
    6. 6. Alamelu Mahalingam, Anthony R. Geonnotti, Jan Balzarini, and Patrick F. Kiser, Activity and Safety of Synthetic Lectins Based on Benzoboroxole-Functionalized Polymers for Inhibition of HIV Entry, Mol. Pharmaceutics 2011, 8, 2465–2475 (link)
    7. 7. Alamelu Mahalingam, Eric Smith, Judit Fabian,  Festo R. Damian, Jennifer J. Peters, Meredith R. Clark, David R. Friend, David F. Katz, Patrick F. Kiser, Design of a Semisolid Vaginal Microbicide Gel by Relating Composition to Properties and Performance, Pharm Res 2010, 27:2478–2491 (link)
    8. 8. Julie I. Jay, Bonnie E. Lai, David G. Myszka, Alamelu Mahalingam, Kris Langheinrich, David F. Katz, and Patrick F. Kiser, Multivalent Benzoboroxole Functionalized Polymers as gp120 Glycan Targeted Microbicide Entry Inhibitors, Mol Pharm 2010, 7(1), 116–129 (link)
    9. 9. Julie I. Jay, Shetha Shukair, Kristofer Langheinrich, Melissa C. Hanson, Gianguido C. Cianci, Todd J. Johnson, Meredith R. Clark, Thomas J. Hope, Patrick F. Kiser, Modulation of Viscoelasticity and HIV Transport as a Function of pH in a Reversibly Crosslinked Hydrogel, Adv. Funct. Mater. 2009, 19, 2969–2977 (link)
    10. 10. Meredith C. Roberts, Alamelu Mahalingam, Melissa C. Hanson, and Patrick F. Kiser, Chemorheology of Phenylboronate-Salicylhydroxamate Cross-Linked Hydrogel Networks with a Sulfonated Polymer Backbone, Macromolecules 2008, 41, 8832-8840 (link)
    11. 11. Meredith C. Roberts, Melissa C. Hanson, Archna P. Massey, Elliott A. Karren, and Patrick F. Kiser, Dynamically Restructuring Hydrogel Networks Formed with Reversible Covalent Crosslinks, Adv. Mater. 2007, 19, 2503–2507 (link)
    12. 12. Kenneth D. Eichenbaum, Allen A. Thomas, Gary M. Eichenbaum, Brian R. Gibney, David Needham, and Patrick F. Kiser, Oligo-R-hydroxy Ester Cross-Linkers: Impact of Cross-Linker Structure on Biodegradable Hydrogel Networks, Macromolecules 2005, 38, 10757-10762 (link)


    Selected review articles

    1. 1. David R. Friend, Patrick F. Kiser, Assessment of topical microbicides to prevent HIV-1 transmission: concepts, testing, lessons learned, Antiviral Research 2013, 99, 391-400 (link)
    2. 2. Patrick F. Kiser, Pedro M. Mesquita, Betsy C. Herold, A perspective on progress and gaps in HIV prevention science, AIDS Research and Human Retroviruses, 2012, 28, 1373-1378 (link)
    3. 3. Patrick F. Kiser, Todd J. Johnson, Justin T. Clark, State of the art in intravaginal ring technology for topical prophylaxis of HIV infection, AIDS Review, 2012, 14, 62-77 (link)

     


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