Joseph R. Moskal, Ph.D.

Overview of the Center

The Falk Center for Molecular Therapeutics is a molecular biology-based drug discovery center of excellence within the Department of Biomedical Engineering at Northwestern Engineering. The Falk Center collaborates with industry partners, including the biopharmaceutical company Aptinyx Inc.

There has never been a greater need for the development of new and effective medicines for the treatment of diseases. However, the costs of creating new drugs have skyrocketed, and therapies for many diseases are not being developed because the patient population is too small to be profitable. A new organizational model is necessary to translate discoveries with therapeutic potential into clinically useful compounds. The Falk Center for Molecular Therapeutics is such a model.

Research

Our research is organized into three different areas:

Learn more about research

Developing Drug Therapies

Rapastinel was purchased by Allergan in 2015 and is being evaluated in a Phase III clinical trial for treatment-resistant depression. Aptinyx has several compounds in clinical development, including NYX-2925 (in Phase II clinical trials for painful diabetic peripheral neuropathy and fibromyalgia), NYX-783 (in a Phase II clinical trial for post-traumatic stress disorder), and NYX-458 (in a Phase I trial to establish safety and tolerability in individuals with cognitive impairment associated with Parkinson's disease).