BME 452: Transport through Connective Tissue

Quarter Offered

Spring : TTh 12:30-2:00 ; Johnson


An undergraduate course in fluid mechanics or transport phenomena. For BME undergraduates, BME 350 is prerequisite.


We will use porous media theory to examine the principles governing fluid flow and mass transfer in the extracellular matrices of the body and show how these principles can be use in tissue engineering. Included will be a detailed consideration of the role of osmotic pressure in tissue transport also with the importance of modeling tissues as biphasic media. We will also consider the importance of electrical phenomena in transport.

Who Takes It


  • Introduction to Extracellular Matrix
  • Darcy’s Law 4/16 Tu Darcy’s Law (examples) 
  • Darcy’s Law (low porosity porous media)
  • Recitation
  • Stereology 
  • Darcy’s Law (high porosity porous media) 
  • Brinkman's Equation (high porosity porous media)
  • Recitation 
  • Biphasic Theory 
  • Biphasic Theory 
  • Osmotic Pressure – fundamentals
  • Osmotic Pressure – polymers
  • Recitation
  • Osmotic Pressure – polymers, charge effects
  • Mass Transport in Porous Media 
  • Electroosmosis, Electrophoresis, Streaming Potential
  • Recitationnone