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• Dec

  10

  IEMS Seminar: Statistical Modeling and Optimization for Optimal Adaptive Trial Design in Personalized Medicine

  Department of Industrial Engineering and Management Sciences

  11:00 AM M228, Technological Institute

  EVENT DETAILS

  Xingyuan Ethan Fang

  Penn State University

  Title: Statistical Modeling and Optimization for Optimal Adaptive Trial Design in Personalized Medicine

  Abstract: We provide a new modeling framework and adopt modern optimization tools to attack an important open problem in statistics. In particular, we consider the optimal adaptive trial design problem in personalized medicine. Adaptive enrichment designs involve preplanned rules for modifying enrollment criteria based on accruing data in a randomized trial. We focus on designs where the overall population is partitioned into two predefined subpopulations, e.g., based on a biomarker or risk score measured at baseline for personalized medicine. The goal is to learn which populations benefit from an experimental treatment. Two critical components of adaptive enrichment designs are the decision rule for modifying enrollment, and the multiple testing procedure. We provide a general framework for simultaneously optimizing these components for two-stage, adaptive enrichment designs through Bayesian optimization. We minimize the expected sample size under constraints on power and the familywise Type I error rate. It is computationally infeasible to directly solve this optimization problem due to its nonconvexity and infinite dimensionality. The key to our approach is a novel, discrete representation of this optimization problem as a sparse linear program, which is large-scale but computationally feasible to solve using modern optimization techniques. Applications of our approach produce new, approximately optimal designs. We shall further discuss several extensions to solve other related statistical problems.

  Biography: Ethan is an assistant professor at Penn State University. Before joining Penn State, he got his PhD from Princeton University in 2016 and his bachelor's degree from the National University of Singapore in 2010. He works on different problems such as statistical learning, high-dimensional inference and adaptive trial design from both statistical and computational perspectives. He won numerous awards in statistics and optimization such as Best Paper Prize for Young Researchers in Continuous Optimization (jointly with Mengdi Wang and Han Liu). the environment and is a Fellow of the American Statistical Association.

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  TIME Tuesday, December 10, 2019 at 11:00 AM - 12:00 PM

  LOCATION M228, Technological Institute    map it

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  CONTACT Agnes Kaminski    a-kaminski@northwestern.edu EMAIL

  CALENDAR Department of Industrial Engineering and Management Sciences

• May

  8

  Extending Care: A Conversation about Conservation and Futurity

  Block Museum of Art

  6:00 PM Block Museum of Art, Mary and Leigh

  EVENT DETAILSmore info

  The Center for Scientific Studies in the Arts is a collaboration between the Art Institute of Chicago and materials science-related departments at Northwestern University to pursue objects-based and objects-inspired scientific research. Materials research benefits ongoing work in conservation, archaeology, art history, and curatorial scholarship.

  Learn how the Center uses materials research to care for art objects in sustainable, innovative ways with Maria Kokkori, Northwestern Associate Professor of Electrical and Computer Engineering and Senior Scientist in the Center for Scientific Studies in the Arts. She will be in conversation with Corey Byrnes, Northwestern Associate Professor of Chinese Culture and co-founder/co-director of the Environmental Humanities Workshop in Kaplan Humanities Center.

  This event is presented by the McCormick School of Engineering and Applied Science in conjunction with exhibition Actions for the Earth: Art, Care & Ecology.

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  TIME Wednesday, May 8, 2024 at 6:00 PM - 7:30 PM

  LOCATION Block Museum of Art, Mary and Leigh    map it

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  CONTACT Block Museum of Art    block-museum@northwestern.edu EMAIL

  CALENDAR Block Museum of Art

• Jun

  10

  Northwestern Engineering PhD Hooding and Master's Degree Recognition Ceremony

  McCormick School of Engineering and Applied Science

  9:00 AM Welsh-Ryan Arena

  EVENT DETAILSmore info

  McCormick School of Engineering PhD Hooding and Master’s Degree Recognition Ceremony

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  TIME Monday, June 10, 2024 at 9:00 AM - 11:00 AM

  LOCATION Welsh-Ryan Arena   

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  CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

  CALENDAR McCormick School of Engineering and Applied Science

• Jun

  10

  Northwestern Engineering Undergraduate Convocation

  McCormick School of Engineering and Applied Science

  2:00 PM Welsh-Ryan Arena

  EVENT DETAILSmore info

  McCormick School of Engineering Undergraduate Convocation

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  TIME Monday, June 10, 2024 at 2:00 PM - 4:00 PM

  LOCATION Welsh-Ryan Arena   

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  CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

  CALENDAR McCormick School of Engineering and Applied Science