Prof. Deming Chen is the Abel Bliss Professor of the Grainger College of Engineering at University of Illinois at Urbana-Champaign (UIUC). His current research interests include reconfigurable computing, hybrid cloud, system-level design methodologies, machine learning and acceleration, and hardware security. In this talk, Dr. Chen will present some new concepts and research results that demonstrate initial promises to overcome these challenges, including shared virtual memory system for computing with FPGAs, scalable high-level synthesis for FPGA programming, and trusted execution environment with accelerators. These results are developed within the AMD-Xilinx Center of Excellence and the Hybrid-Cloud Thrust of the IBM-Illinois Discovery Accelerator Institute at UIUC.