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Drug Delivery Strategies for Local Immunomodulation in Atherosclerosis
Atherosclerosis is a leading cause of cardiovascular disease, which is responsible for one in three deaths globally. Characterized by the blocking of arteries, atherosclerosis develops when lipids accumulate in arterial walls and harden into a plaque. When macrophages consume excess modified low-density lipoprotein, they become inflamed and transform into foam cells, which further contribute to plaque development. The standard of care for atherosclerosis treatment includes diet and exercise and lipid-lowering therapies such as statins that do not fully address the inflammation that underlies the disease. While many anti-inflammatory therapies have shown promise in vitro and in vivo, they have not been translated into clinical settings. This lack of clinical application is largely due to the non-selectivity and non-specificity of these drugs, leading to significant side effects. This seminar will discuss the development of advanced drug delivery systems, which aim to target inflammatory pathways with enhanced selectivity and precision.
Lisa Volpatti is an Assistant Professor of Biomedical Engineering and Chemical & Biological Engineering at Northwestern University, where her lab focuses on immunoengineering strategies to treat chronic inflammatory diseases. She completed her Ph.D. in Chemical Engineering at MIT under the mentorship of Dan Anderson and Bob Langer and her postdoctoral training at the University of Chicago Pritzker School of Molecular Engineering with Jeff Hubbell.
TIME Wednesday April 30, 2025 at 12:00 PM - 2:00 PM
LOCATION LR4, Technological Institute map it
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CONTACT Will Chaussee william.chaussee@northwestern.edu
CALENDAR McCormick-Chemical and Biological Engineering (ChBE)