Department Events

Events

  • Feb
    15-15

    ChBE Seminar Series

    McCormick-Chemical and Biological Engineering

    8:45 AM L361, Technological Institute

    EVENT DETAILS

    William Bothfeld, Tyo Lab:

    Title
    A glucose-sensing toggle switch for autonomous, high productivity genetic control

    Abstract
    Great progress has been made in expanding the number and types of chemicals made biologically. Many of the strategies to biosynthesize these chemicals involve production during cell growth. This scheme is inherently limited because feedstock (e.g., sugar) is converted to excess biomass instead of product, essential genes must be maintained for cell growth, and a high titer of product can be toxic to growth and may limit yields. A two-stage growth and production phase strategy could avoid these issues. At bench scale, chemical additions turn on production pathways in cells to implement two-phase strategies. However, these chemicals are expensive and not practical for large scale production. We have developed a genetic toggle switch that uses glucose sensing to enable this two-phase strategy. Temporary glucose starvation precisely and autonomously activates product expression in rich or minimal media, obviating the requirement for inducing chemicals. The switch remains stably in the new state even after reintroduction of glucose. In the context of polyhydroxybutyrate biosynthesis (a bio-polymer), our system enables shorter growth phases and comparable titers to cells that are steadily expressing PHB at near maximal tolerance levels. This two-phase production strategy, and specifically the glucose toggle switch, should be broadly useful to initiate many types of genetic program for metabolic engineering applications.

    Robert Brydon, Broadbelt Lab:

    Title
    Microkinetic modeling of homogeneous and catalyzed oxidation systems

    Abstract
    Epoxidation, a specific form of partial oxidation, is an especially valuable process for the production of resins, plasticizers, curing agents, and more products. Traditional mechanisms used to explain partial oxidation systems are often insufficient when applied to cases where there is a high selectivity to epoxide products. This work sought to create a comprehensive microkinetic model that could be applied to a variety of partial oxidation systems with varying intrinsic selectivities to epoxide products. A challenge in modeling is the ability to sufficiently capture the behavior of complex chemistry without the scale of the model becoming unreasonable. By employing automatic network generation with a reaction family approach, a set of reactions and parameters of manageable size was created for partial oxidation and validated against experimental data. The resultant net flux analysis provided insights that shape a new understanding of epoxidation through radical intermediates. With the contribution of homogeneous oxidation well-defined, the developed microkinetic model was adapted to account for various catalysts. The resultant models were then used to investigate the effect of catalysts, including gold nanoparticles and transition metal oxides, on oxidation activity and selectivity.

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    TIME Thursday, February 15, 2018 at 8:45 AM - 10:00 AM

    LOCATION L361, Technological Institute    map it

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    CONTACT Cody Jarrett    cody.jarrett@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering

  • Aug
    17

    Master's Completion form due for TGS Summer master's candidates

    University Academic Calendar

    All Day

    EVENT DETAILS

    TIME Friday, August 17, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Aug
    18

    Eight-week session ends

    University Academic Calendar

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    EVENT DETAILS

    TIME Saturday, August 18, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Sep
    1

    Ten-week session ends

    University Academic Calendar

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    EVENT DETAILS

    TIME Saturday, September 1, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Sep
    5

    BTP Biosensor Practicum

    McCormick-Chemical and Biological Engineering

    9:00 AM Pancoe Abbott Auditorium, Pancoe-NSUHS Life Sciences Pavilion

    EVENT DETAILS

    TIME Wednesday, September 5, 2018 at 9:00 AM - 2:30 PM

    LOCATION Pancoe Abbott Auditorium, Pancoe-NSUHS Life Sciences Pavilion    map it

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    CONTACT Emily Kocevar    e-kocevar@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering

  • Sep
    7

    Summer Degrees Conferred

    University Academic Calendar

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    EVENT DETAILS

    TIME Friday, September 7, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Sep
    17

    TGS Graduate Student Orientation

    University Academic Calendar

    All Day

    EVENT DETAILS

    TIME Monday, September 17, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Sep
    21

    New Student Orientation (Wildcat Welcome)

    University Academic Calendar

    All Day

    EVENT DETAILS

    TIME Friday, September 21, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Sep
    24

    New Graduate Student Fall Registration begins 9 a.m.

    University Academic Calendar

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    EVENT DETAILS

    TIME Monday, September 24, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Sep
    25

    New Undergraduate Student Fall Registration

    University Academic Calendar

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    EVENT DETAILS

    TIME Tuesday, September 25, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Sep
    27

    Fall classes begin 8 a.m.

    University Academic Calendar

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    EVENT DETAILS

    TIME Thursday, September 27, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Sep
    27-6

    ChBE Seminar Series: Mark Styczinski

    McCormick-Chemical and Biological Engineering

    9:00 AM L211, Technological Institute

    EVENT DETAILS

    TIME Thursday, September 27, 2018 at 9:00 AM - 10:00 AM

    LOCATION L211, Technological Institute    map it

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    CONTACT Elizabeth Rentfro    elizabeth.rentfro@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering

  • Oct
    4-6

    ChBE Seminar Series: Charles Sing

    McCormick-Chemical and Biological Engineering

    9:00 AM L211, Technological Institute

    EVENT DETAILS

    TIME Thursday, October 4, 2018 at 9:00 AM - 10:00 AM

    LOCATION L211, Technological Institute    map it

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    CONTACT Elizabeth Rentfro    elizabeth.rentfro@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering

  • Oct
    11-6

    ChBE Seminar Series: Mahdi Abu-Omar

    McCormick-Chemical and Biological Engineering

    9:00 AM L211, Technological Institute

    EVENT DETAILS

    TIME Thursday, October 11, 2018 at 9:00 AM - 10:00 AM

    LOCATION L211, Technological Institute    map it

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    CONTACT Elizabeth Rentfro    elizabeth.rentfro@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering