BME 349-1-20: Regenerative Engineering Principles and Technologies

Quarter Offered

Fall : TTh 11:00am-12:20pm ; Liu


BIO_SCI 215. For 2019-2020: Bio 215 and Bio 219


Foundations, principles, and technologies of molecular, cellular, and tissue regenerative engineering.

Who Takes It

Senior undergraduate and graduate students.

What It's About

This course addresses the fundamentals of cell regeneration, principles and technologies of regenerative medicine and engineering, and application of regenerative engineering principles to regenerative medicine.


  • Molecular basis of regenerative engineering
  • Embryonic development
  • Embryonic stem cells
  • Somatic stem cells
  • Somatic cell and tissue regeneration
  • Gene-based regenerative engineering
  • Identification of pathogenic genes
  • Gene recombination and manipulations
  • Biological mediations of gene transfer
  • Chemical and physical mediations of gene transfer
  • Small interfering RNAs for mRNA modulations
  • Epigenetic modulations
  • MicroRNA modulations
  • Gene editing
  • Stem cell-based regenerative engineering
  • Tissue regenerative engineering


Shu Q. Liu, Bioregenerative Engineering: Principles and Applications, Wiley Interscience, New York, 2007.

Shu Q. Liu, Cardiovascular Protective and Regenerative Engineering, World Scientific, 2017 (tentatively).