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  • Dec
    2

    Kresimir Josic: Mathematical Modeling for the Rational Design of Synthetic Microbial Consortia

    McCormick-Engineering Sciences and Applied Mathematics

    4:00 PM M416, Technological Institute

    EVENT DETAILS

    Title: Mathematical Modeling for the Rational Design of Synthetic Microbial Consortia

    Speaker: Kresimir Josic Ph.D., The University of Houston

    Abstract: Synthetic microbial consortia have a number of advantages over isogenic system as biochemical and regulatory tasks can be divided between the strains. However, the complexity of these systems makes it difficult to engineer them from scratch. Coordinating gene expression is particularly challenging in spatially extended consortia because the range of signaling molecules is limited by diffusion.

    I will discuss two examples where mathematical modeling and analysis allowed us to understand experimentally observed dynamics in such a system, and use such modeling to control their behavior. First, I will show how modeling predicts that spatio-temporal coordination of gene expression can be achieved even when the spatial extent of a consortium is much greater than the diffusion distance of the signaling molecules. Experiments confirmed these observations and the need for an intrinsic positive feedback loop that amplifies and propagates intercellular signals. In a second example, we built a three-strain consortium that pulses in response to an external signal. We also developed a computational model that predicts the system's behavior at different strain ratios and can be used to control its dynamics. Our work thus shows that mathematical modeling can be used to rationally and predictably tune complex synthetic biological systems allowing us to engineer biology more rapidly.

    Co-Sponsored by the NSF-funded Research Training Grant in Quantitative Biological Modeling

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    TIME Monday, December 2, 2019 at 4:00 PM - 5:00 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Kendall Minta    kendall.minta@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics

  • Apr
    30

    Appl Math: Ehud Yariv on "Shocks and Caps in Drop Electrohydrodynamics"

    McCormick-Engineering Sciences and Applied Mathematics (ESAM)

    11:15 AM M416, Technological Institute

    EVENT DETAILS

    TIME Tuesday, April 30, 2024 at 11:15 AM - 12:15 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Ted Shaeffer    ted.shaeffer@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)

  • May
    7

    Appl Math: Pankaj Mehta on "Mathematics of Life Seminar Series: Randomness, Complexity, and the Biological Frontier"

    McCormick-Engineering Sciences and Applied Mathematics (ESAM)

    11:15 AM M416, Technological Institute

    EVENT DETAILS

    TIME Tuesday, May 7, 2024 at 11:15 AM - 12:15 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Ted Shaeffer    ted.shaeffer@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)

  • May
    8

    Extending Care: A Conversation about Conservation and Futurity

    Block Museum of Art

    6:00 PM Block Museum of Art, Mary and Leigh

    EVENT DETAILSmore info

    TIME Wednesday, May 8, 2024 at 6:00 PM - 7:30 PM

    LOCATION Block Museum of Art, Mary and Leigh    map it

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    CONTACT Block Museum of Art    block-museum@northwestern.edu EMAIL

    CALENDAR Block Museum of Art

  • May
    14

    Appl Math: Rony Granek on "Active Fractal Networks with Stochastic Force Monopoles and Force Dipoles Unravel Subdiffusion of Chromosomal Loci"

    McCormick-Engineering Sciences and Applied Mathematics (ESAM)

    11:15 AM M416, Technological Institute

    EVENT DETAILS

    TIME Tuesday, May 14, 2024 at 11:15 AM - 12:15 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Ted Shaeffer    ted.shaeffer@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)

  • May
    21

    Appl Math: Andrew Stuart on "Title TBA"

    McCormick-Engineering Sciences and Applied Mathematics (ESAM)

    11:15 AM M416, Technological Institute

    EVENT DETAILS

    TIME Tuesday, May 21, 2024 at 11:15 AM - 12:15 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Ted Shaeffer    ted.shaeffer@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)

  • May
    28

    Appl Math: Pascale Garaud on "Title TBA"

    McCormick-Engineering Sciences and Applied Mathematics (ESAM)

    11:15 AM M416, Technological Institute

    EVENT DETAILS

    TIME Tuesday, May 28, 2024 at 11:15 AM - 12:15 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Ted Shaeffer    ted.shaeffer@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)

  • Jun
    10

    Northwestern Engineering PhD Hooding and Master's Degree Recognition Ceremony

    McCormick School of Engineering and Applied Science

    9:00 AM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 9:00 AM - 11:00 AM

    LOCATION Welsh-Ryan Arena   

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    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Jun
    10

    Northwestern Engineering Undergraduate Convocation

    McCormick School of Engineering and Applied Science

    2:00 PM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 2:00 PM - 4:00 PM

    LOCATION Welsh-Ryan Arena   

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    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Aug
    14

    Undergraduate Quantum Summer School

    McCormick School of Engineering and Applied Science

    All Day Ford Motor Company Engineering Design Center

    EVENT DETAILSmore info

    TIME Wednesday, August 14, 2024

    LOCATION Ford Motor Company Engineering Design Center    map it

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    CONTACT Dongyang Li    lidongyang@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Aug
    15

    Undergraduate Quantum Summer School

    McCormick School of Engineering and Applied Science

    All Day Ford Motor Company Engineering Design Center

    EVENT DETAILSmore info

    TIME Thursday, August 15, 2024

    LOCATION Ford Motor Company Engineering Design Center    map it

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    CONTACT Dongyang Li    lidongyang@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science