Department Events

Events

  • May
    21

    Paul Fran├žois: Untangling the hairball of immune recognition networks

    McCormick-Engineering Sciences and Applied Mathematics

    4:00 PM M416, Technological Institute

    EVENT DETAILS

    Title: Untangling the hairball of immune recognition networks

    Speaker: Paul François Associate Professor of Physics, Rutherford Physics Building, McGill University

    Abstract: Complex mathematical models of interaction networks are routinely used for prediction in systems biology. However, it is difficult to reconcile network complexities with a formal understanding of their behavior. I will introduce several models of immune recognition by T cells and will show how a simple procedure can be used to reduce them to functional submodules, using statistical mechanics of complex systems combined with a fitness-based approach inspired by in silico evolution. Our procedure works by putting parameters or combination of parameters to some asymptotic limit, while keeping (or slightly improving) the model performance, and requires parameter symmetry breaking for more complex models. An intractable model of immune recognition with close to a hundred individual transition rates is reduced to a simple two-parameter model, and connected to the "adaptive sorting" principle that we previously identified and experimentally validated. Our procedure extracts three different mechanisms for early immune recognition, and automatically discovers similar functional modules in different models of the same process allowing for model classification and comparison.

    Note: Cookies will be served at 3:30

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    TIME Monday, May 21, 2018 at 4:00 PM - 5:00 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Beth Anne Siculan    b-siculan@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics

  • Oct
    22

    Yuhai Tu: Principles of Sensory Adaptation

    McCormick-Engineering Sciences and Applied Mathematics

    4:00 PM M416, Technological Institute

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    TIME Monday, October 22, 2018 at 4:00 PM - 5:00 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Jawaad Ahmad    jawaad.ahmad@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics

  • Nov
    12

    Registration for Winter 2019 begins

    University Academic Calendar

    All Day

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    TIME Monday, November 12, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

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  • Nov
    21

    Thanksgiving vacation begins 6 p.m.

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    TIME Wednesday, November 21, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

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  • Nov
    22

    Thanksgiving day

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    TIME Thursday, November 22, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

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  • Nov
    26

    Fall Classes resume 8 a.m.

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    TIME Monday, November 26, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

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  • Dec
    8

    Fall classes end

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    TIME Saturday, December 8, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

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