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  • May
    21

    Paul François: Untangling the hairball of immune recognition networks

    McCormick-Engineering Sciences and Applied Mathematics

    4:00 PM M416, Technological Institute

    EVENT DETAILS

    Title: Untangling the hairball of immune recognition networks

    Speaker: Paul François Associate Professor of Physics, Rutherford Physics Building, McGill University

    Abstract: Complex mathematical models of interaction networks are routinely used for prediction in systems biology. However, it is difficult to reconcile network complexities with a formal understanding of their behavior. I will introduce several models of immune recognition by T cells and will show how a simple procedure can be used to reduce them to functional submodules, using statistical mechanics of complex systems combined with a fitness-based approach inspired by in silico evolution. Our procedure works by putting parameters or combination of parameters to some asymptotic limit, while keeping (or slightly improving) the model performance, and requires parameter symmetry breaking for more complex models. An intractable model of immune recognition with close to a hundred individual transition rates is reduced to a simple two-parameter model, and connected to the "adaptive sorting" principle that we previously identified and experimentally validated. Our procedure extracts three different mechanisms for early immune recognition, and automatically discovers similar functional modules in different models of the same process allowing for model classification and comparison.

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    TIME Monday, May 21, 2018 at 4:00 PM - 5:00 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Beth Anne Siculan    b-siculan@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics

  • Apr
    23

    Appl Math: Tom Dean on "Contrail Climate Impacts: Modeling and Mitigation Strategies"

    McCormick-Engineering Sciences and Applied Mathematics (ESAM)

    11:15 AM M416, Technological Institute

    EVENT DETAILS

    TIME Tuesday, April 23, 2024 at 11:15 AM - 12:15 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Ted Shaeffer    ted.shaeffer@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)

  • Apr
    30

    Appl Math: Ehud Yariv on "Shocks and Caps in Drop Electrohydrodynamics"

    McCormick-Engineering Sciences and Applied Mathematics (ESAM)

    11:15 AM M416, Technological Institute

    EVENT DETAILS

    TIME Tuesday, April 30, 2024 at 11:15 AM - 12:15 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Ted Shaeffer    ted.shaeffer@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)

  • May
    7

    Appl Math: Pankaj Mehta on "Mathematics of Life Seminar Series: Randomness, Complexity, and the Biological Frontier"

    McCormick-Engineering Sciences and Applied Mathematics (ESAM)

    11:15 AM M416, Technological Institute

    EVENT DETAILS

    TIME Tuesday, May 7, 2024 at 11:15 AM - 12:15 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Ted Shaeffer    ted.shaeffer@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)

  • May
    8

    Extending Care: A Conversation about Conservation and Futurity

    Block Museum of Art

    6:00 PM Block Museum of Art, Mary and Leigh

    EVENT DETAILSmore info

    TIME Wednesday, May 8, 2024 at 6:00 PM - 7:30 PM

    LOCATION Block Museum of Art, Mary and Leigh    map it

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    CONTACT Block Museum of Art    block-museum@northwestern.edu EMAIL

    CALENDAR Block Museum of Art

  • May
    14

    Appl Math: Rony Granek on "Active Fractal Networks with Stochastic Force Monopoles and Force Dipoles Unravel Subdiffusion of Chromosomal Loci"

    McCormick-Engineering Sciences and Applied Mathematics (ESAM)

    11:15 AM M416, Technological Institute

    EVENT DETAILS

    TIME Tuesday, May 14, 2024 at 11:15 AM - 12:15 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Ted Shaeffer    ted.shaeffer@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)

  • May
    21

    Appl Math: Andrew Stuart on "Title TBA"

    McCormick-Engineering Sciences and Applied Mathematics (ESAM)

    11:15 AM M416, Technological Institute

    EVENT DETAILS

    TIME Tuesday, May 21, 2024 at 11:15 AM - 12:15 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Ted Shaeffer    ted.shaeffer@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)

  • May
    28

    Appl Math: Pascale Garaud on "Title TBA"

    McCormick-Engineering Sciences and Applied Mathematics (ESAM)

    11:15 AM M416, Technological Institute

    EVENT DETAILS

    TIME Tuesday, May 28, 2024 at 11:15 AM - 12:15 PM

    LOCATION M416, Technological Institute    map it

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    CONTACT Ted Shaeffer    ted.shaeffer@northwestern.edu EMAIL

    CALENDAR McCormick-Engineering Sciences and Applied Mathematics (ESAM)

  • Jun
    10

    Northwestern Engineering PhD Hooding and Master's Degree Recognition Ceremony

    McCormick School of Engineering and Applied Science

    9:00 AM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 9:00 AM - 11:00 AM

    LOCATION Welsh-Ryan Arena   

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    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Jun
    10

    Northwestern Engineering Undergraduate Convocation

    McCormick School of Engineering and Applied Science

    2:00 PM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 2:00 PM - 4:00 PM

    LOCATION Welsh-Ryan Arena   

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    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science