News & Events
Department Events

Events

  • Jun
    4

    ME 512 Seminar - Prashant Purohit - Elasticity as the basis of allosteric interactions in DNA and membranes

    McCormick - Mechanical Engineering

    3:00 PM L211, Technological Institute

    EVENT DETAILS

    Monday, June 4, 2018

    3:00pm - 4:00pm

    Elasticity as the basis of allosteric interactions in DNA and membranes

    Abstract
    In mechanics the forces of interaction between defects in an elastic solid are well understood. Just as defects produce local elastic fields in a solid, proteins binding to DNA also deform it locally. Since DNA behaves like an elastic rod at scales of a few tens of nanometers, we expect that if two proteins bind to DNA separated by a distance r then their deformation fields will overlap and lead to an interaction energy that depends on r. This problem has not been theoretically addressed so far, but there is experimental evidence of the interaction.

    For example, gene expression, which depends on RNA polymerase binding affinity to DNA, is a function of the proximity of LacR and RNA polymerase. These effects are called allosteric interactions on DNA. In this talk we will use a birod model of DNA to study how proteins deform it locally, and how this leads to allosteric interactions between them.

    Similar elastic deformations caused by proteins binding to lipid bilayers also result in allosteric interactions that are responsible for cellular processes, such as, endo- and exo-cytosis required for transport of materials into and out of cells. Often, allostery also involves entropic forces between the proteins that are the result of fluctuations caused by Brownian motion of the elastic media (DNA or lipid membrane) separating them. We will briefly discuss how such entropic interactions between proteins bound to lipid membranes can be described quantitatively within a semi-analytic computational model.

    Biography
    Prashant Purohit is currently Associate Professor of Mechanical Engineering and Applied Mechanics at the University of Pennsylvania. He got his PhD at Caltech in 2002. His interests are in problems at the interface of mechanics, physics and biology. He has worked on mechanics of DNA, mechanics of blood clots and mechanics of lipid membranes. The interplay of solid mechanics and Brownian motion in these and other problems is of particular interest to him.

    more less

    TIME Monday, June 4, 2018 at 3:00 PM - 4:00 PM

    LOCATION L211, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Theresa Santos    tami.santos@northwestern.edu EMAIL

    CALENDAR McCormick - Mechanical Engineering

  • Apr
    22

    ME512 Distinguished Speaker Seminar Marcia K. O'Malley

    McCormick - Mechanical Engineering (ME)

    3:00 PM LR3, Technological Institute

    EVENT DETAILS

    TIME Monday, April 22, 2024 at 3:00 PM - 4:00 PM

    LOCATION LR3, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Jeremy Wells    jeremywells@northwestern.edu EMAIL

    CALENDAR McCormick - Mechanical Engineering (ME)

  • Apr
    30

    ME Alumni Seminar Series- Apostolos Karafillis

    McCormick - Mechanical Engineering (ME)

    2:00 PM 1.350, Ford Motor Company Engineering Design Center

    EVENT DETAILS

    TIME Tuesday, April 30, 2024 at 2:00 PM - 3:00 PM

    LOCATION 1.350, Ford Motor Company Engineering Design Center    map it

    ADD TO CALENDAR

    CONTACT Jeremy Wells    jeremywells@northwestern.edu EMAIL

    CALENDAR McCormick - Mechanical Engineering (ME)

  • May
    3

    Russ Tedrake, MIT and Toyota Research Institute, "Dexterous Manipulation with Diffusion Policies"

    Center for Robotics and Biosystems (CRB)

    11:30 AM M416, Technological Institute

    EVENT DETAILSmore info

    TIME Friday, May 3, 2024 at 11:30 AM - 12:30 PM

    LOCATION M416, Technological Institute    map it

    ADD TO CALENDAR

    CONTACT Amy Nedoss    amy.nedoss@northwestern.edu EMAIL

    CALENDAR Center for Robotics and Biosystems (CRB)

  • May
    8

    Extending Care: A Conversation about Conservation and Futurity

    Block Museum of Art

    6:00 PM Block Museum of Art, Mary and Leigh

    EVENT DETAILSmore info

    TIME Wednesday, May 8, 2024 at 6:00 PM - 7:30 PM

    LOCATION Block Museum of Art, Mary and Leigh    map it

    ADD TO CALENDAR

    CONTACT Block Museum of Art    block-museum@northwestern.edu EMAIL

    CALENDAR Block Museum of Art

  • Jun
    10

    Northwestern Engineering PhD Hooding and Master's Degree Recognition Ceremony

    McCormick School of Engineering and Applied Science

    9:00 AM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 9:00 AM - 11:00 AM

    LOCATION Welsh-Ryan Arena   

    ADD TO CALENDAR

    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Jun
    10

    Northwestern Engineering Undergraduate Convocation

    McCormick School of Engineering and Applied Science

    2:00 PM Welsh-Ryan Arena

    EVENT DETAILSmore info

    TIME Monday, June 10, 2024 at 2:00 PM - 4:00 PM

    LOCATION Welsh-Ryan Arena   

    ADD TO CALENDAR

    CONTACT Amy Pokrass    amy.pokrass@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science