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May23
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Engineering immunity against infectious disease and cancer via new nanomaterials
Presented by: Darrell Irvine
Abstract: Our laboratory focuses on applying principles from engineering and technologies from materials science, chemistry, and bioengineering to develop new approaches to study the immune system, create new diagnostics, and create next generation vaccines and cancer immunotherapies. Three vignettes of approaches we have explored spanning infectious disease, vaccines, and cancer immunotherapy will be presented. Gold nanoparticles have been extensively studied as nanomaterials for drug delivery and diagnostics. We have recently studied the in vivo behavior of a particular class of organic ligand-protected gold nanoparticles, which are capable of sequestering hydrophobic drugs and cell penetrating behavior. A novel approach for tracking gold nanoparticles in vivo using single cell mass cytometry will be described, as well as the application of the these nanomaterials as antibiotic delivery agents to block the lethal dissemination of bacterial infections. We have also developed strategies to enhanced vaccines and immunotherapy based on two different approaches to the design of “hitchhiking– therapeutics: First, an approach to enhance adoptive cell therapy (ACT) for cancer will be described. ACT using patient-derived tumor-specific T-cells is a promising approach for cancer treatment, but strategies to enhance ACT T-cell functionality in vivo are needed. We developed a strategy combining nanomedicine with ACT, based on the chemical conjugation of drug-loaded nanoparticles (NPs) as synthetic “backpacks– to the surfaces of live lymphocytes for ACT. Second, a novel strategy for targeting antigens and immunostimulatory agents to lymph nodes will be described, based on the design of albumin-binding amphiphiles-peptides and amphiphile-adjuvants. These “albumin-hitchhiking– amphiphiles were efficiently delivered to lymph nodes following injection, leading to as much as 30-fold amplified cellular immune responses and anti-tumor immunity. In ongoing preclinical studies, we have discovered combination immunotherapies that leverage these very potent engineered peptide vaccines to eradicate established immunosuppressive tumors in a majority of treated animals, providing proof of concept that the endogenous immune system is capable of eliminating large established tumors. These examples illustrate the power of bioengineering approaches in shaping the immune response and studying immune cell biology.
Bio: Darrell Irvine, Ph.D., is a Professor at the Massachusetts Institute of Technology and an Investigator of the Howard Hughes Medical Institute. He also serves on the steering committee of the Ragon Institute of MGH, MIT, and Harvard. His research is focused on the application of engineering tools to problems in cellular immunology and the development of new materials for vaccine and drug delivery. Current efforts are focused on problems related to vaccine development for HIV and and immunotherapy of cancer. Dr. Irvine's work has been recognized by numerous awards, including a Beckman Young Investigator award, an NSF CAREER award, selection for Technology Review's ‘TR35', election as a Fellow of the Biomedical Engineering Society, election as a fellow of the American Institute for Medical and Biological Engineering, and appointment as an investigator of the Howard Hughes Medical Institute. He is the author of over 100 publications, reviews, and book chapters and an inventor on numerous patents.
TIME Tuesday, May 23, 2017 at 4:00 PM - 5:00 PM
LOCATION L361 Technological Institute map it
CONTACT Department Office matsci@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering
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Apr22
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-Policy & ProceduresTIME Monday, April 22, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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Apr25
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-Policy & ProceduresTIME Thursday, April 25, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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Apr29
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-Policy & ProceduresTIME Monday, April 29, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May2
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-Policy & ProceduresTIME Thursday, May 2, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May6
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-Policy & ProceduresTIME Monday, May 6, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May8
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lessThe Center for Scientific Studies in the Arts is a collaboration between the Art Institute of Chicago and materials science-related departments at Northwestern University to pursue objects-based and objects-inspired scientific research. Materials research benefits ongoing work in conservation, archaeology, art history, and curatorial scholarship.
Learn how the Center uses materials research to care for art objects in sustainable, innovative ways with Maria Kokkori, Northwestern Associate Professor of Electrical and Computer Engineering and Senior Scientist in the Center for Scientific Studies in the Arts. She will be in conversation with Corey Byrnes, Northwestern Associate Professor of Chinese Culture and co-founder/co-director of the Environmental Humanities Workshop in Kaplan Humanities Center.
This event is presented by the McCormick School of Engineering and Applied Science in conjunction with exhibition Actions for the Earth: Art, Care & Ecology.
TIME Wednesday, May 8, 2024 at 6:00 PM - 7:30 PM
LOCATION Block Museum of Art, Mary and Leigh map it
CONTACT Block Museum of Art block-museum@northwestern.edu EMAIL
CALENDAR Block Museum of Art
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May9
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-Policy & ProceduresTIME Thursday, May 9, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May13
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-Policy & ProceduresTIME Monday, May 13, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May16
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-Policy & ProceduresTIME Thursday, May 16, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May20
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-Policy & ProceduresTIME Monday, May 20, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May23
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-Policy & ProceduresTIME Thursday, May 23, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May27
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-Policy & ProceduresTIME Monday, May 27, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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May30
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-Policy & ProceduresTIME Thursday, May 30, 2024 at 10:00 AM - 11:00 AM
LOCATION 2036, Cook Hall map it
CONTACT Wade Tischhauser wade@northwestern.edu EMAIL
CALENDAR Department of Materials Science and Engineering (MatSci)
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Jun10
EVENT DETAILSmore info
lessMcCormick School of Engineering PhD Hooding and Master’s Degree Recognition Ceremony
TIME Monday, June 10, 2024 at 9:00 AM - 11:00 AM
LOCATION Welsh-Ryan Arena
CONTACT Amy Pokrass amy.pokrass@northwestern.edu EMAIL
CALENDAR McCormick School of Engineering and Applied Science
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Jun10
TIME Monday, June 10, 2024 at 2:00 PM - 4:00 PM
LOCATION Welsh-Ryan Arena
CONTACT Amy Pokrass amy.pokrass@northwestern.edu EMAIL
CALENDAR McCormick School of Engineering and Applied Science