Department Events

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  • May
    23

    MSE Colloquium - Darrell Irvine

    Department of Materials Science and Engineering

    4:00 PM L361 Technological Institute

    EVENT DETAILSmore info

    MSE Colloquium - Darrell Irvine

    Engineering immunity against infectious disease and cancer via new nanomaterials

    Presented by: Darrell Irvine

    Abstract: Our laboratory focuses on applying principles from engineering and technologies from materials science, chemistry, and bioengineering to develop new approaches to study the immune system, create new diagnostics, and create next generation vaccines and cancer immunotherapies. Three vignettes of approaches we have explored spanning infectious disease, vaccines, and cancer immunotherapy will be presented. Gold nanoparticles have been extensively studied as nanomaterials for drug delivery and diagnostics. We have recently studied the in vivo behavior of a particular class of organic ligand-protected gold nanoparticles, which are capable of sequestering hydrophobic drugs and cell penetrating behavior. A novel approach for tracking gold nanoparticles in vivo using single cell mass cytometry will be described, as well as the application of the these nanomaterials as antibiotic delivery agents to block the lethal dissemination of bacterial infections. We have also developed strategies to enhanced vaccines and immunotherapy based on two different approaches to the design of “hitchhiking– therapeutics: First, an approach to enhance adoptive cell therapy (ACT) for cancer will be described. ACT using patient-derived tumor-specific T-cells is a promising approach for cancer treatment, but strategies to enhance ACT T-cell functionality in vivo are needed. We developed a strategy combining nanomedicine with ACT, based on the chemical conjugation of drug-loaded nanoparticles (NPs) as synthetic “backpacks– to the surfaces of live lymphocytes for ACT. Second, a novel strategy for targeting antigens and immunostimulatory agents to lymph nodes will be described, based on the design of albumin-binding amphiphiles-peptides and amphiphile-adjuvants. These “albumin-hitchhiking– amphiphiles were efficiently delivered to lymph nodes following injection, leading to as much as 30-fold amplified cellular immune responses and anti-tumor immunity. In ongoing preclinical studies, we have discovered combination immunotherapies that leverage these very potent engineered peptide vaccines to eradicate established immunosuppressive tumors in a majority of treated animals, providing proof of concept that the endogenous immune system is capable of eliminating large established tumors. These examples illustrate the power of bioengineering approaches in shaping the immune response and studying immune cell biology.

    Bio: Darrell Irvine, Ph.D., is a Professor at the Massachusetts Institute of Technology and an Investigator of the Howard Hughes Medical Institute. He also serves on the steering committee of the Ragon Institute of MGH, MIT, and Harvard. His research is focused on the application of engineering tools to problems in cellular immunology and the development of new materials for vaccine and drug delivery. Current efforts are focused on problems related to vaccine development for HIV and and immunotherapy of cancer. Dr. Irvine's work has been recognized by numerous awards, including a Beckman Young Investigator award, an NSF CAREER award, selection for Technology Review's ‘TR35', election as a Fellow of the Biomedical Engineering Society, election as a fellow of the American Institute for Medical and Biological Engineering, and appointment as an investigator of the Howard Hughes Medical Institute. He is the author of over 100 publications, reviews, and book chapters and an inventor on numerous patents.

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    TIME Tuesday, May 23, 2017 at 4:00 PM - 5:00 PM

    LOCATION L361 Technological Institute    map it

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    CONTACT Department Office    matsci@northwestern.edu EMAIL

    CALENDAR Department of Materials Science and Engineering

  • Oct
    24

    MSE Colloquium - Xin Sun

    Department of Materials Science and Engineering

    4:00 PM L211, Technological Institute

    EVENT DETAILS

    TIME Tuesday, October 24, 2017 at 4:00 PM - 5:00 PM

    LOCATION L211, Technological Institute    map it

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    CONTACT Department Office    matsci@northwestern.edu EMAIL

    CALENDAR Department of Materials Science and Engineering

  • Oct
    24

    Abraham Cruzvillegas: Self-Construction

    McCormick School of Engineering and Applied Science

    4:00 PM 1-350, ITW classroom, Ford Motor Company Engineering Design Center

    EVENT DETAILS

    TIME Tuesday, October 24, 2017 at 4:00 PM - 5:00 PM

    LOCATION 1-350, ITW classroom, Ford Motor Company Engineering Design Center    map it

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    CONTACT Northwestern Engineering Events    northwestern-engineering-events@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Nov
    7

    MSE Colloquium - Skin-Inspired Organic Electronic Materials and Devices - Zhenen Bao

    Department of Materials Science and Engineering

    4:00 PM L211, Technological Institute

    EVENT DETAILSmore info

    TIME Tuesday, November 7, 2017 at 4:00 PM - 5:00 PM

    LOCATION L211, Technological Institute    map it

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    CONTACT Department Office    matsci@northwestern.edu EMAIL

    CALENDAR Department of Materials Science and Engineering

  • Nov
    9

    McCormick Global Initiatives Fair

    McCormick School of Engineering and Applied Science

    11:00 AM Main Lobby, Technological Institute

    EVENT DETAILSmore info

    TIME Thursday, November 9, 2017 at 11:00 AM - 2:00 PM

    LOCATION Main Lobby, Technological Institute    map it

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    CONTACT Ana Maria Andras    ana.andras@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Nov
    14

    MSE Colloquium - Nancy Sottos

    Department of Materials Science and Engineering

    4:00 PM L211, Technological Institute

    EVENT DETAILS

    TIME Tuesday, November 14, 2017 at 4:00 PM - 5:00 PM

    LOCATION L211, Technological Institute    map it

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    CONTACT Department Office    matsci@northwestern.edu EMAIL

    CALENDAR Department of Materials Science and Engineering

  • Nov
    21

    MSE Colloquium - Veronica Augustyn

    Department of Materials Science and Engineering

    4:00 PM L211, Technological Institute

    EVENT DETAILS

    TIME Tuesday, November 21, 2017 at 4:00 PM - 5:00 PM

    LOCATION L211, Technological Institute    map it

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    CONTACT Department Office    matsci@northwestern.edu EMAIL

    CALENDAR Department of Materials Science and Engineering