EVENT DETAILS
Babatunde A. Ogunnaike William L. Friend Chaired Professor of Chemical Engineering; Dean, College of EngineeringUniversity of Delaware
BIOLOGICAL CONTROL SYSTEMSSystems Biology of Diseases and the Design of Effective TreatmentsThe mammalian organism maintains stable, efficient and "near-optimal" performance and homeostasis in the face of external and internal perturbations via distinct biological systems ranging from the large-scale physiological (nervous, endocrine, immune, circulatory, respiratory, etc.), to the cellular (growth and proliferation regulation, DNA damage repair, etc.), and the sub-cellular (gene expression, protein synthesis, metabolite regulation, etc). "Biological Control Systems," a sub-topic of Control Theory, arises from a control engineering perspective of the function, organization, and coordination of these multi-scale biological systems and the control mechanisms that enable them to carry out their functions effectively. In this presentation, we will provide an overview of how physiological life is made possible by control, and demonstrate the usefulness of a control engineering perspective of pathologies for diagnosis, design, and implementation of effective treatments. The concepts and principles will be illustrated using three specific examples with significant research and clinical implications: Ca++ Regulation (see Fig 1); TGF-? and prostate cancer; and Platelet Count Control.
BiographyThe Ogunnaike group is interested in understanding the dynamic behavior of complex systems through mathematical modeling and analysis, and then exploiting this understanding for postulating novel designs and improved operation. Specific systems of interest range from polymer reactors, particulate processes and extruders, to biological processes at the cellular and physiological levels. Specific research topics include modeling and control of industrial processes (polymer reactors, extruders, distillation columns); the application of process analytical technology for control of pharmaceutical processes; modeling and control of hybrid renewable energy systems; biological control systems; and systems biology with application to neuronal responses and cancer.
Dr Ogunnaike is the author or co-author of more than 100 peer-reviewed publications, and four books including a widely used textbook, Process Dynamics, Modeling and Control, published in 1994 by Oxford University Press, and Random Phenomena: Fundamentals of Probability and Statistics for Engineers, published in 2009 by CRC Press. He is an Associate Editor of the journal Industrial and Engineering Chemistry Research. His awards include the American Institute of Chemical Engineers 1998 CAST Computing Practice Award, the 2004 University of Delaware's College of Engineering Excellence in Teaching award, the 2007 ISA Eckman Award, and the 2008 AACC Control Engineering Practice award. He was named a fellow of the American Institute of Chemical Engineers (AIChE) in 2009, and elected a fellow of the Nigerian Academy of Engineering in 2012, of the US National Academy of Inventors in 2014. He is a 2016 fellow of the American Association for the Advancement of Science (AAAS) and a 2017 fellow of International Federation of Automatic Control (IFAC). He was elected to the US National Academy of Engineering in 2012.
TIME Thursday September 21, 2017 at 9:00 AM - 10:00 AM
LOCATION M345, Technological Institute map it
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CONTACT Elizabeth Rentfro elizabeth.rentfro@northwestern.edu
CALENDAR McCormick-Chemical and Biological Engineering