Skin is the body's largest organ, and is responsible for the transduction of a vast amount of information. This conformable, stretchable and biodegradable material simultaneously collects signals from external stimuli that translate into information such as pressure, pain, and temperature. The development of electronic materials, inspired by the complexity of this organ is a tremendous, unrealized materials challenge. However, the advent of organic-based electronic materials may offer a potential solution to this longstanding problem. In this talk, I will describe the design of organic electronic materials and devices to mimic skin functions. These new materials enabled unprecedented performance and functions in devices that are of interest for bio-electronic interfaces and applications.