Abstract: t is well known that meso-scale microstructural features and their stability and evolution under service condition control the macroscopic performance for most engineering materials. Even though the precise definition of meso-scale may be material specific, meso-scale typically serves as the critical linkage between the bottom-up materials science-based approach and the top-down materials engineering-based approach. In this talk, asuite of modeling capabilities will be discussed to predict the influences of microstructure features and their evolution kinetics on engineering properties of advanced multiphase materials. The key challenge addressed is the quantitative linkages between the lower length scale performance limiting factors and the macroscopic engineering properties.