EVENT DETAILSmore info
Mark Byrne, PhDProfessor and Head of Biomedical EngineeringRowan UniversityHost: Professor Mark Johnson
Title:"Engineering Macromolecular Memory for Controlled Therapeutic Release"
Abstract:Biomaterials that utilize biology in their design are prime candidates for the creation of enhanced delivery systems with tremendous promise to profoundly impact medicine via improved treatment options for disease and better quality of life. Within the field of advanced drug delivery, major emphasis is now being focused toward engineering the architectural design of biomaterials at the molecular level.Our group has pioneered the creation of macromolecular memory via multiple polymer chains within polymer networks that can significantly extend and control drug release as well as increase drug payload compared to conventional methods. Macromolec ular memory can be achieved by templating techniques, which involve the formation of a pre-polymerization complex between the template therapeutic and functional monomers and oligomers by non-covalent chemistry. The first part of this presentation will discuss fundamental aspects in the design, characterization, and analysis of these polymer networks and focus on the complex relationship between network formation, network structure and compositions, and template binding and transport. My group has begun to answer fundamental questions on the nature of this phenomena on the chain level. Emerging translational areas involve numerous thin film and micro/nanoparticle therapeutic release platforms. For example, my team has created a number of novel contact lenses with controlled transport of various therapeutics that can deliver constant amounts of medication to the eye for the duration of lens wear from days to weeks.This talk will also highlight the conjugation of nucleic acid (NA), biohybrid constructs to produce novel biomaterials and nanoparticle drug delivery carriers with programmable on-demand modulatory mechanisms, with unprecedented control and sensitivity. Our innovative platform exploits the power of NAs to control and modulate the release of a single therapeutic or multiple therapeutics in response to a variety of stimuli. By exploiting NA-drug bimolecular interactions, we have demonstrated that therapeutic payload can be very high per nanoparticle (approaching 1,000 molecules of drug per 30nm carrier) and tuning NA-drug affinity can lead to fine control over the multi-day drug release profile. In controlled drug delivery, one of the biggest obstacles has been the engineering of multi-drug releasing constructs with high drug payloads and tunable control of release kinetics.
TIME Thursday October 20, 2016 at 4:00 PM - 5:00 PM
LOCATION L361 Technological Institute map it
ADD TO CALENDAR&group= echo $value['group_name']; ?>&location= echo htmlentities($value['location']); ?>&pipurl= echo $value['ppurl']; ?>" class="button_outlook_export">
CONTACT Jonathan T. Parker jtp@northwestern.edu
CALENDAR McCormick - Biomedical Engineering Department