Department Events

Events

  • Feb
    15-15

    ChBE Seminar Series

    McCormick-Chemical and Biological Engineering

    8:45 AM L361, Technological Institute

    EVENT DETAILS

    William Bothfeld, Tyo Lab:

    Title
    A glucose-sensing toggle switch for autonomous, high productivity genetic control

    Abstract
    Great progress has been made in expanding the number and types of chemicals made biologically. Many of the strategies to biosynthesize these chemicals involve production during cell growth. This scheme is inherently limited because feedstock (e.g., sugar) is converted to excess biomass instead of product, essential genes must be maintained for cell growth, and a high titer of product can be toxic to growth and may limit yields. A two-stage growth and production phase strategy could avoid these issues. At bench scale, chemical additions turn on production pathways in cells to implement two-phase strategies. However, these chemicals are expensive and not practical for large scale production. We have developed a genetic toggle switch that uses glucose sensing to enable this two-phase strategy. Temporary glucose starvation precisely and autonomously activates product expression in rich or minimal media, obviating the requirement for inducing chemicals. The switch remains stably in the new state even after reintroduction of glucose. In the context of polyhydroxybutyrate biosynthesis (a bio-polymer), our system enables shorter growth phases and comparable titers to cells that are steadily expressing PHB at near maximal tolerance levels. This two-phase production strategy, and specifically the glucose toggle switch, should be broadly useful to initiate many types of genetic program for metabolic engineering applications.

    Robert Brydon, Broadbelt Lab:

    Title
    Microkinetic modeling of homogeneous and catalyzed oxidation systems

    Abstract
    Epoxidation, a specific form of partial oxidation, is an especially valuable process for the production of resins, plasticizers, curing agents, and more products. Traditional mechanisms used to explain partial oxidation systems are often insufficient when applied to cases where there is a high selectivity to epoxide products. This work sought to create a comprehensive microkinetic model that could be applied to a variety of partial oxidation systems with varying intrinsic selectivities to epoxide products. A challenge in modeling is the ability to sufficiently capture the behavior of complex chemistry without the scale of the model becoming unreasonable. By employing automatic network generation with a reaction family approach, a set of reactions and parameters of manageable size was created for partial oxidation and validated against experimental data. The resultant net flux analysis provided insights that shape a new understanding of epoxidation through radical intermediates. With the contribution of homogeneous oxidation well-defined, the developed microkinetic model was adapted to account for various catalysts. The resultant models were then used to investigate the effect of catalysts, including gold nanoparticles and transition metal oxides, on oxidation activity and selectivity.

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    TIME Thursday, February 15, 2018 at 8:45 AM - 10:00 AM

    LOCATION L361, Technological Institute    map it

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    CONTACT Cody Jarrett    cody.jarrett@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering

  • May
    28

    Memorial Day (no classes)

    University Academic Calendar

    All Day

    EVENT DETAILS

    TIME Monday, May 28, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • May
    30-6

    BTP Seminar Series, Larissa Wenning

    McCormick-Chemical and Biological Engineering

    12:00 PM L361, Technological Institute

    EVENT DETAILS

    TIME Wednesday, May 30, 2018 at 12:00 PM - 1:00 PM

    LOCATION L361, Technological Institute    map it

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    CONTACT Emily Kocevar    e-kocevar@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering

  • May
    31

    Symposium on Regenerative Engineering

    Center for Advanced Regenerative Engineering

    7:30 AM LSouth/LNorth, Prentice Women's Hospital

    EVENT DETAILSmore info

    TIME Thursday, May 31, 2018 at 7:30 AM - 6:30 PM

    LOCATION LSouth/LNorth, Prentice Women's Hospital    map it

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    CONTACT Tara Sadera    tara.sadera@northwestern.edu EMAIL

    CALENDAR Center for Advanced Regenerative Engineering

  • May
    31-7

    ChBE Seminar Series: Rick Register

    McCormick-Chemical and Biological Engineering

    9:00 AM M345, Technological Institute

    EVENT DETAILSmore info

    TIME Thursday, May 31, 2018 at 9:00 AM - 10:00 AM

    LOCATION M345, Technological Institute    map it

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    CONTACT Elizabeth Rentfro    elizabeth.rentfro@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering

  • Jun
    6

    BTP Seminar Series, Chetan Goudar

    McCormick-Chemical and Biological Engineering

    12:00 PM L361, Technological Institute

    EVENT DETAILS

    TIME Wednesday, June 6, 2018 at 12:00 PM - 1:00 PM

    LOCATION L361, Technological Institute    map it

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    CONTACT Emily Kocevar    e-kocevar@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering

  • Jun
    7

    ChBE Seminar Series: Marianthi Ierapetritou

    McCormick-Chemical and Biological Engineering

    9:00 AM M345, Technological Institute

    EVENT DETAILSmore info

    TIME Thursday, June 7, 2018 at 9:00 AM - 10:00 AM

    LOCATION M345, Technological Institute    map it

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    CONTACT Elizabeth Rentfro    elizabeth.rentfro@northwestern.edu EMAIL

    CALENDAR McCormick-Chemical and Biological Engineering

  • Jun
    9

    Spring classes end

    University Academic Calendar

    All Day

    EVENT DETAILS

    TIME Saturday, June 9, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Jun
    11

    Spring examinations begin

    University Academic Calendar

    All Day

    EVENT DETAILS

    TIME Monday, June 11, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Jun
    16

    Spring examinations end

    University Academic Calendar

    All Day

    EVENT DETAILS

    TIME Saturday, June 16, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Jun
    22

    Commencement

    University Academic Calendar

    All Day

    EVENT DETAILS

    TIME Friday, June 22, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar

  • Jun
    22

    Northwestern Engineering - PhD Hooding Ceremony

    McCormick School of Engineering and Applied Science

    2:00 PM Ryan Family Auditorium, Technological Institute

    EVENT DETAILSmore info

    TIME Friday, June 22, 2018 at 2:00 PM - 3:30 PM

    LOCATION Ryan Family Auditorium, Technological Institute    map it

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    CONTACT Bruce Lindvall    b-lindvall@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Jun
    22

    McCormick Dean's Graduation Tent Reception

    McCormick School of Engineering and Applied Science

    4:00 PM East Lawn, Norris University Center

    EVENT DETAILSmore info

    TIME Friday, June 22, 2018 at 4:00 PM - 6:00 PM

    LOCATION East Lawn, Norris University Center    map it

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    CONTACT Northwestern Engineering Event    mccormick-events@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Jun
    23

    Northwestern Engineering Undergraduate Convocation

    McCormick School of Engineering and Applied Science

    8:00 AM Ryan Field

    EVENT DETAILSmore info

    TIME Saturday, June 23, 2018 at 8:00 AM - 9:45 AM

    LOCATION Ryan Field    map it

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    CONTACT Ann Anderson    ann.anderson@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Jun
    23

    McCormick Master's Recognition Ceremony*

    McCormick School of Engineering and Applied Science

    11:00 AM Ryan Family Auditorium, Technological Institute

    EVENT DETAILSmore info

    TIME Saturday, June 23, 2018 at 11:00 AM - 12:30 PM

    LOCATION Ryan Family Auditorium, Technological Institute    map it

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    CONTACT Bruce Lindvall    b-lindvall@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Jun
    23

    McCormick Master's Recognition Ceremony**

    McCormick School of Engineering and Applied Science

    2:00 PM Ryan Family Auditorium, Technological Institute

    EVENT DETAILSmore info

    TIME Saturday, June 23, 2018 at 2:00 PM - 3:30 PM

    LOCATION Ryan Family Auditorium, Technological Institute    map it

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    CONTACT Bruce Lindvall    b-lindvall@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Jul
    4

    Independence Day (no classes)

    University Academic Calendar

    All Day

    EVENT DETAILS

    TIME Wednesday, July 4, 2018

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    CONTACT Office of the Registrar    nu-registrar@northwestern.edu EMAIL

    CALENDAR University Academic Calendar