Department Events

  • Jun
    1

    BME Seminar Series: Ning Wang, PhD

    McCormick - Biomedical Engineering Department

    4:00 PM L361 Technological Institute

    EVENT DETAILSmore info

    Ning Wang, PhD
    Leonard C. and Mary Lou Hoeft Professor
    University of Illinois at Urbana-Champaign
    Host: Professor Mark Johnson

    Title:
    “Force-induced direct gene transcription in living cells–

    Abstract:
    Despite decades of efforts, it remains elusive how physical forces influence gene expression in living cells and tissues. Here we show that gene transcription can be upregulated via force-induced direct chromatin stretching. Using green fluorescent protein (GFP) to label multiple sites in a chromatin domain and inserting a gene of interest between GFP spots, we were able to quantify the degree of chromatin stretching and transcription in a living cell. We found that transcription upregulation depended on force magnitude, force directionality, and the degree of chromatin stretching as well as tension in the cytoskeleton. Disrupting the force propagating pathway from the cytoplasm to the nuclear lamina abolished force-induced transcription. We discovered two nuclear proteins that transmitted force from nuclear lamins to the chromatin. We highlight our recent findings that forces and matrix mechanics regulate stem cell differentiation, early embryonic development, and growth and metastasis of malignant tumor-repopulating cells. Our findings demonstrate the critical roles of mechanotransduction in stem cell biology and cancer cell biology.

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    TIME Thursday, June 1, 2017 at 4:00 PM - 5:00 PM

    LOCATION L361 Technological Institute    map it

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    CONTACT Jody Hoks    jody.hoks@northwestern.edu EMAIL

    CALENDAR McCormick - Biomedical Engineering Department

  • Oct
    24

    Abraham Cruzvillegas: Self-Construction

    McCormick School of Engineering and Applied Science

    4:00 PM 1-350, ITW classroom, Ford Motor Company Engineering Design Center

    EVENT DETAILS

    TIME Tuesday, October 24, 2017 at 4:00 PM - 5:00 PM

    LOCATION 1-350, ITW classroom, Ford Motor Company Engineering Design Center    map it

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    CONTACT Northwestern Engineering Events    northwestern-engineering-events@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Oct
    26

    BME Seminar Series: Milica Radisic, PhD

    McCormick - Biomedical Engineering Department

    4:00 PM L361, Technological Institute

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    TIME Thursday, October 26, 2017 at 4:00 PM - 5:00 PM

    LOCATION L361, Technological Institute    map it

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    CONTACT Anna Wegener    anna.wegener@northwestern.edu EMAIL

    CALENDAR McCormick - Biomedical Engineering Department

  • Nov
    2

    BME Seminar Series: Alumni Speakers

    McCormick - Biomedical Engineering Department

    4:00 PM L361, Technological Institute

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    TIME Thursday, November 2, 2017 at 4:00 PM - 5:00 PM

    LOCATION L361, Technological Institute    map it

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    CONTACT Anna Wegener    anna.wegener@northwestern.edu EMAIL

    CALENDAR McCormick - Biomedical Engineering Department

  • Nov
    9

    McCormick Global Initiatives Fair

    McCormick School of Engineering and Applied Science

    11:00 AM Main Lobby, Technological Institute

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    TIME Thursday, November 9, 2017 at 11:00 AM - 2:00 PM

    LOCATION Main Lobby, Technological Institute    map it

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    CONTACT Ana Maria Andras    ana.andras@northwestern.edu EMAIL

    CALENDAR McCormick School of Engineering and Applied Science

  • Nov
    9

    BME Seminar Series: Michael Cho, PhD

    McCormick - Biomedical Engineering Department

    4:00 PM L361, Technological Institute

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    TIME Thursday, November 9, 2017 at 4:00 PM - 5:00 PM

    LOCATION L361, Technological Institute    map it

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    CONTACT Anna Wegener    anna.wegener@northwestern.edu EMAIL

    CALENDAR McCormick - Biomedical Engineering Department

  • Nov
    16

    BME Seminar Series: Matthew Tirrell, PhD

    McCormick - Biomedical Engineering Department

    4:15 PM L361, Technological Institute

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    TIME Thursday, November 16, 2017 at 4:15 PM - 5:15 PM

    LOCATION L361, Technological Institute    map it

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    CONTACT Anna Wegener    anna.wegener@northwestern.edu EMAIL

    CALENDAR McCormick - Biomedical Engineering Department

  • Nov
    30

    BME Seminar Series: Tania Douglas, PhD

    McCormick - Biomedical Engineering Department

    4:00 PM L361, Technological Institute

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    TIME Thursday, November 30, 2017 at 4:00 PM - 5:00 PM

    LOCATION L361, Technological Institute    map it

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    CONTACT Anna Wegener    anna.wegener@northwestern.edu EMAIL

    CALENDAR McCormick - Biomedical Engineering Department