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Descriptions
BME 475: Cardiovascular Biology & Engineering

Quarter Offered

Spring : TTh 9:30-10:50 ; Liu

Prerequisites

None

Description

Molecular basis of cardiovascular development, performance, and pathogenesis; engineering analysis of cardiovascular functions; and fundamentals of cardiovascular engineering and regeneration.

Who Takes It

This course is designed for graduate students.

What It's About

This course addresses the molecular basis of cardiovascular development and pathogenesis, engineering analysis of cardiovascular function, and fundamentals of cardiovascular regeneration and engineering.

Minisyllabus

Part I: Introduction to the cardiovascular system

  • Cardiac physiology and pathophysiology
  • Vascular cell function

Part II: Cardiovascular development

  • Cardiovascular stem cells and morphogenesis
  • Myocardial regeneration

Part III: Regulatory mechanisms of cell regeneration

  • General mechanisms of cell signaling
  • Cytokine biology
  • Receptor and Non-receptor protein tyrosine kinase-mediated cell signaling
  • Protein phosphatase-mediated cell signaling
  • G-protein receptor-mediated cell signaling
  • Cytokine-JAK-STAT-mediated cell signaling
  • NFκB-mediated cell signaling
  • Cell proliferation and differentiation
  • Cell apoptosis

Part IV: Mechanical aspects of cardiovascular adaptation and pathogenesis

  • Solid stress and strain analysis in the vascular system
  • Fluid shear stress and strain rate analysis in the vascular system
  • Hypertension and the role of mechanical stretch in regulating cardiovascular adaptation and pathogenesis
  • Atherogenesis and the role of blood shear stress in regulating vascular adaptation and pathogenesis

Part V: Labs and design project

  • Lab 1: Detection of smooth muscle actin filaments
  • Lab 2: Cell proliferation
  • Lab 3: Cell apoptosis
  • Design project presentation

Textbook

Shu Q. Liu, Cardiovascular Regenerative Engineering, World Scientific Publishing, in preparation.

Syllabus