Courses
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Descriptions
BME 447: Drug Delivery, formerly 495-0-22

Quarter Offered

Fall : MW 11-12:30 ; Kiser

Prerequisites

Graduate Standing

Description

The class seeks to describe the fundamental composition, structure, property and performance relationships in classical drug delivery systems.

Who Takes It

Graduate students in biomedical engineering take this course. Some graduates from other programs like chemical and biomolecular engineering, chemistry, and mechanical engineering can also take the class particularly if their research interests align with this area of investigation. Students take BMD ENG 495 to become familiar with the underlying ideas behind the design testing and construction of drug delivery systems to deliver drugs to treat disease.

What It's About

This physically focused course endeavors to give the student a fundamental understanding of functional drug delivery systems. This course provides students a firm understanding of:

  • The rationale behind the engineering of controlled drug delivery systems
  • How they are configures to overcome absorption barriers
  • How the systems are tested both in the lab and clinically

To this end, the class focuses on the barriers to drug delivery, pharmacokinetics, classical drug delivery systems (matrix and reservoir); the materials used in drug delivery systems, and a critical review of several clinically relevant drug delivery systems themselves. The class gives the student a foundation with which to categorize and evaluate the delivery of any drug targeted for a specific indication.

Minisyllabus

  • Drug delivery systems-matrix
  • Diffusion of drugs in vitro and in vivo
  • Drug permeability
  • Properties of drug substances
  • Barriers to drug diffusion
  • Oral absorption of drugs
  • Pharmacokinetics
  • Drug delivery systems-reservoirs
  • Formulations, Polymers, and Gels
  • Prodrugs
  • Liposomes
  • Pegylated proteins
  • Polymeric Prodrugs

Textbook

Saltzman; Drug Delivery: Engineering Principles for Drug Therapy. 2001 Oxford University Press.