BME 425: fMRI (Functional Imaging), formerly 495-0-21

Quarter Offered

None : TBA ; Wyrwicz, Pottumarthi


BME 327 (Magnetic Resonance Imaging) or BME 325 (Introduction to Medical Imaging) advisable.


The course will provide a broad overview of imaging applications that are beyond simple anatomic depiction . While MRI will be predominantly discussed modality, there will be discussions regarding other modalities and highlight the major pros and cons with each of them. Principl es of tracer methods used in imaging, fMRI contrast mechanisms, scanning techniques , temporal and spatial limits and both research and clinical applications will be discussed. The concepts of molecular imaging of specific molecular events will also be presented. The lectures by instructors and other experts from this region will be combined with students’ presentations and discussions of current papers describing applications of the methods introduced in the lectures. By the end of the course, students should have a fundamental knowledge of cutting - edge functional imaging techniques and their applications in research and clinical practice


  • Functional Imaging – more than anatomy
  • Perfusion-based and Flow-based functional MRI: principles, imaging techniques, applications
  • Neuro fMRI demo
  • PET imaging
  • Diffusion tensor imaging applications
  • Non-neuro fMRI applications (heart, kidney, lung, etc.)
  • Neuro fMRI applications
  • Resting State fMRI
  • Magnetic Nanostructures: Diagnostic and Theranostic applications
  • In-utero diffusion imaging in hypoxia-ischemia model to predict post-natal outcomes
  • Metabolic imaging: biochemical events, principles of MR Spectroscopy, intrinsic & extrinsic multinuclear probes, localized MR spectroscopy techniques (single voxel, multi voxel), data analysis, applications
  • Molecular imaging: principles, MRI contrast agents, scanning methods, applications


Clinical Perfusion MRI: Techniques and Applications Peter Barker, Xavier Golay, and Gregory Zaharchuk Cambridge University Press, 2013

Introduction to Functional Magnetic Resonance Imaging Principles & Techniques By Richard B. Buxton Cambridge University Press, 2002

Functional MRI an introduction to methods Edited by Peter Jezzard, Pau l M. Matthews, Stephen M. Smith Oxford University Press, 2001

Functional MRI Edited by C.T.W. Moonen & P.A. Bandettini Springer -Verlag, 2000

Diffusion and Perfusion Magnetic Resonance Imaging Applications to Functional MRI Edited by Denis Le Bihan Raven Press, 1995

Imaging Drug Action in the Brain Edited by Edythe D. London CRC Press, 1993

In-vivo magnetic resonance spectroscopy Guest -editor, M. Rudin NMR, basic principles and progress; vol 26 Springer -Verlag, 1992

Magnetic resonance spectroscopy diagn osis of neurological diseases Else Rubaek Danielsen, Brian Ross M. Dekker, 1999 (Galter Library)