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BME 314: Models of Biochemistry and Molecular Biology

Quarter Offered

Fall : MWF 12:00-12:50 ; Wu

Prerequisites

Junior standing recommended

Description

Engineering modeling of some central problems in biochemistry and molecular biology will be discussed in detail. Examples include the DNA double helix model as related to the experimental results from X-ray diffraction studies, model of genetic transduction as applied to map distances in bacterial genomes, prediction of protein folding based on amino acid sequences, model of hemoglobin saturation with oxygen depending on allosteric effects, etc.

Who Takes It

Juniors and seniors in biomedical engineering take it. In addition, any student interested in quantitative analysis of problems in biochemistry and molecular can take it. They include graduate students in biomedical engineering, other engineering students interested in modern biology, and students in biological sciences with some knowledge of mathematics and physics.

What It Is About

Biology has evolved rapidly during the past three to four decades. In addition to the classical descriptive approaches, chemistry, mathematics and physics have been thoroughly incorporated. Thus, besides anatomy and physiology, biochemistry, molecular biology, cell biology, bio-informatics, analytical biology, etc. have flourished. Biomedical engineers are in a unique position to capture such developments. Quantitative models can be constructed based on collections of experimental findings and predictions can be made beyond the capability of pure description.

Mini-syllabus

  • Antibody binding antigens
  • Saturation of hemoglobin with oxygen at equilibrium
  • Co-transduction and location of bacterial genetic markers
  • Enzyme kinetics
  • The phi and psi angles of proteins
  • Prediction of protein folding
  • Structure of polynucleotides
  • Fiber X-ray diffraction and DNA double helix

Textbook

  • Analytical Molecular Biology, by Tai Te Wu, Kluwer 2001
  • Current literature